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 TERMINÉ 

Astronomy ESFRI and Research Infrastructure Cluster (ASTERICS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

ASTERICS (Astronomy ESFRI & Research Infrastructure Cluster) aims to address the cross-cutting synergies and common challenges shared by the various Astronomy ESFRI facilities (SKA, CTA, KM3Net & E-ELT). It brings together for the first time, the astronomy, astrophysics and particle astrophysics communities, in addition to other related research infrastructures. The major objectives of ASTERICS ar ...
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 24

 TERMINÉ 
MooDFOOD is a Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression. Depression is one of the most prevalent, severe and disabling disorders in the EU and places a heavy burden on individuals and families. A large proportion of the EU population is overweight which increases depression risk. Improving food-related behaviour and ...
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 17

 TERMINÉ 
Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

Long-term effects of early nutrition on later health (EARLYNUTRITION)

Date du début: 1 févr. 2012, Date de fin: 31 oct. 2017,

Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 indi ...
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 40

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

 TERMINÉ 

Advanced Multidisciplinary Training in Molecular Bacteriology (AMBER)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"The advancement in life sciences has created a growing number of disciplines that are required to elucidate the increasingly complicated biological questions. This has led to an unsurpassed level of knowledge, but it has also resulted in a continuous specialization in PhD trainings, which makes the students less prepared for complex present day biological questions. To provide a better comprehens ...
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 9

 TERMINÉ 

Transitioning towards Urban Resilience and Sustainability (TURAS)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

The “TURaS” project aims to bring together urban communities, researchers, local authorities and SMEs to research, develop, demonstrate and disseminate transition strategies and scenarios to enable European cities and their rural interfaces to build vitally-needed resilience in the face of significant sustainability challenges. To ensure maximum impact, the TURaS project has developed an innovati ...
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 34

 TERMINÉ 

The Human Brain Project (HBP)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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 116

 TERMINÉ 
WASTECOSMART - Optimisation of Integrated Solid Waste Management Strategies for the Maximisation of Resource Efficiency addresses the priority areas of a “Resource Efficient Europe” and relates to the EcoAP, by boosting innovation based on research and technology development within the field of integrated waste management. Through cross border cooperation and collaborative research activities betw ...
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 22

 TERMINÉ 

The MEtabolic Road to DIAstolic Heart Failure (MEDIA)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements c ...
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 23

 TERMINÉ 

Sarcomere based Signals in Muscle Remodelling (SARCOSI)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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 14

 TERMINÉ 

Sustainable prevention of obesity through integrated strategies (SPOTLIGHT)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

BACKGROUNDThe prevalence of overweight and obesity in Europe is high and contribute to mortality and the burden of many chronic diseases, especially within groups of lower social-economic status. Obesity is largely determined by modifiable lifestyle dependent risk factors such as reduced physical activity, sedentary behaviour and an unhealthy diet. There is growing evidence that influences on indi ...
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 16

 TERMINÉ 
Although scientific knowledge to respond to outbreaks has increased, deficiencies remain in the ability of health authorities to communicate the need for large-scale measures such as vaccination and antiviral therapy and increase its acceptance. For effective behavioural and communication strategies, integration is needed of social, behavioural, communication and media sciences.We bring together t ...
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 13

 TERMINÉ 
In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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 12

 TERMINÉ 
Indications exist that close contact with nature brings benefits to human health and well-being. The proposed work will investigate the interconnections between exposure to natural outdoor environments, in both rural and urban settings, and better human health and well-being in the North West, South and East of Europe. The project will explore the underlying mechanisms at work (stress reduction/re ...
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 13

 TERMINÉ 
Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine ex ...
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 18

 TERMINÉ 
The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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 26

 TERMINÉ 

Integrated non-CO2 Greenhouse gas Observing System (INGOS)

Date du début: 1 oct. 2011, Date de fin: 31 déc. 2015,

InGOS will support and integrate the observing capacity of Europe for non-CO2 greenhouse gases (NCGHG: CH4, N2O, SF6, H2 and halocarbons). The emissions of these gases are very uncertain and it is unknown how future climate change will feedback into the land use coupled emissions of CH4 and N2O. The NCGHG atmospheric abundances will increase further in the future and the emissions of these gases a ...
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 39

 TERMINÉ 

European Training and Research in Peritoneal Dialysis (EUTRIPD)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

Peritoneal dialysis (PD) and haemodialysis (HD) are life-saving renal replacement therapies for more than 200,000 patients with chronic kidney disease in Europe, and this number increases annually. Although PD and HD have similar mortality rates, PD offers major advantages in terms of quality of life, costs, home-based treatment opportunities and early patient survival. Moreover, PD, rather than H ...
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 13

 TERMINÉ 
LASERLAB-EUROPE III is the European Consortium of major Laser Research Infrastructures, forming a FP7 Integrated Infrastructure Initiative. Geographically it covers the majority of European member states, following recent efforts to include partners from all over Europe 27. Scientifically, it covers many areas of laser science and applications with particular emphasis on short-pulses and high-inte ...
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 26

 TERMINÉ 

Transglutaminase in disease: a novel therapeutic target? (TRANSPATH)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

"TRANSPATH is a multisectorial Network designed to facilitate the exchange of knowledge and technology between 7 leading European research teams and 3 SME partners and 2 associate SME Partners involved in basic and applied research into transglutaminase (TG) related human diseases. Its ambitions are to accelerate the development of new strategies for the treatment and diagnosis of human diseases ...
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 12

 TERMINÉ 
Europe needs to transform itself to a low-carbon economy by mid-century. The existing instrument mix needs to be scaled up drastically to initiate the changes needed across the economy. As the scale and scope of instruments increases, their interaction becomes more important, as do constraints on the political, legal and administrative feasibility. To evaluate their efficiency and effectiveness, i ...
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 12

 TERMINÉ 

REstoring rivers FOR effective catchment Management (REFORM)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

REFORM is targeted towards development of guidance and tools to make river restoration and mitigation measures more cost-effective and to support the 2nd and future River Basin Management Plans (RMBPs) for the WFD. Aims of REFORM are (1) to provide a framework for improving the success of hydromorphological restoration measures and (2) to assess more effectively the state of rivers, floodplains an ...
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 28

 TERMINÉ 
...t of permafrost will have a major impact on the Earth system, affecting global climate through the mobilization of carbon and nitrogen stored in permafrost.PAGE21 aims to understand and quantify the vulnerability of permafrost environments to a changing global climate, and to investigate the feedback mechanisms associated with increasing greenhouse gas emissions from permafrost zones. This researc ...
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 20

 TERMINÉ 

Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
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 19

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 
... and strengthen rainfed agriculture, improve rural livelihood and increase food production and security in Sub-Saharan Africa. In total 3 European and 5 African organisations will be involved; namely VU University Amsterdam (The Netherlands), Newcastle University (United Kingdom), Stockholm Resilience Centre (Sweden), University of Kwazulu Natal (South Africa), Sokoine University (Tanzania), South ...
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 10

 TERMINÉ 

IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
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 14

 TERMINÉ 
The objective of NEUJOBS is to imagine future, or rather various possible futures, under the conditions of the socioecological transition (and incorporating other key influences), map the implications for employment overall, but also in key sectors and relevant groups and integrate all of this together under a single intellectual framework. It will do so by combining EU-wide studies based on exist ...
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 31

 TERMINÉ 
"The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a pr ...
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 12

 TERMINÉ 
The provision of public goods (including landscape services) in rural areas is recognized as one of the key topics for the future of agriculture and rural policy. Agriculture plays a major role in landscape management through its complex interlinkages with landscape features. In turn, the Common Agricultural Policy (CAP) remains an important driver of landscape management due to its importance as ...
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 12

 TERMINÉ 
"INTERFLAME aims to enhance scientific understanding of how and to what extent organic flame retardant (FR) chemicals present in consumer goods and materials contaminate the environment, with particular reference to humans and wildlife. INTERFLAME’s twin foci are exposure arising from indoor contamination and monitoring the efficacy of recent actions designed to reduce environmental levels. Recent ...
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 6

 TERMINÉ 

Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

...in functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relati ...
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 19

 TERMINÉ 

Study of Strongly Interacting Matter (HADRONPHYSICS3)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The Project promotes the access to five European Research Infrastructures, and it is structured into nine Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities.The Project will profit of the success of the previous HadronPhysics project in FP6 and the current HadronPhysics2 in FP7, and originates from the initiative of more than 2.500 European scienti ...
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 52

 TERMINÉ 

Indoor Contamination with Flame Retardant Chemicals: Causes and Impacts (INFLAME)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

"The main research goal is to further understanding of how and to what extent flame retardant (FR) chemicals used in every-day consumer goods and construction materials enter humans and of the risk to health that such exposure presents. Our vision is that this enhanced understanding will inform assessment of risk associated both with recent and current-use flame retardant chemicals, and of those u ...
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 11

 TERMINÉ 
The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to ...
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 9

 TERMINÉ 
AMAZALERT will enable raising the alert about critical feedbacks between climate, society, land-use change, vegetation change, water availability and policies in Amazonia. We will:1) analyze and improve coupled models of global climate and Amazon, land use, vegetation and socio-economic drivers to quantify anthropogenic and climate induced land-use and land cover change and non-linear, irreversibl ...
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 16

 TERMINÉ 
EURO IMPACT aims to develop a multi-disciplinary, multi-professional and intersectorial educational and research training network aimed at monitoring and improving palliative care in Europe. Palliative care is less than optimal in many developed countries and some patients suffer from severe symptoms. While international research on palliative care has begun to develop over the past decades, it ha ...
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 9

 TERMINÉ 
Africa is probably the most vulnerable continent to climate change and climate variability and shows diverse range of agro-ecological and geographical features. Thus the impacts of climate change can be very high and will greatly differ across the continent, and even within countries. There is a urgent need for the most appropriate and up-to-date tools to better understand and predict climate chan ...
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 20