Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Opinion Dynamics and Cultural Conflict in European Spaces (ODYCCEUS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Social media and the digitization of news and discussion fora are having far-reaching effects on the way individuals and communities communicate, organize, and express themselves. Can the information circulating on these platforms be tapped to better understand and analyze the enormous problems facing our contemporary society? Could this help us to better monitor the growing number of social crise ...
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10
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TERMINÉ
European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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43
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TERMINÉ
Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex (EPISTOP)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usual ...
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16
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TERMINÉ
MIME - MOBILITY AND INCLUSION IN MULTILINGUAL EUROPE (MIME)
Date du début: 1 mars 2014, Date de fin: 31 août 2018,
Using an innovative interdisciplinary approach, MIME will generate an organised body of policy-relevant propositions addressing the full range of questions raised in the call. Our aim is to identify the language policies and strategies that best combine “mobility” and “inclusion”.MIME emphasises complementarity between disciplines, and brings together researchers from sociolinguistics, political s ...
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23
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TERMINÉ
Development of in vitro and in vivo strategies to avoid and cure male infertility (GROWSPERM)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
"In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children ...
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7
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TERMINÉ
Next Zero Energy Buildings at lowest Cost by using Competitive Sustainable Technology (NEXT-BUILDINGS)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
This project is about the demonstration of very low energy buildings. In all demonstrations, the ambition is net zero carbon/energy or better (active or plus-energy house). The project paves the way for large scale implementation of energy neutral buildings/neighbourhoods as foreseen in the Energy Performance of Buildings directive and the pilots are running more than five years ahead of the goal ...
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14
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TERMINÉ
Evolution of Shared Semantics in Computational Environments (ESSENCE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
"In everyday life, humans exhibit strong skills in resolving communication problems by re-negotiating what theymean. Modern-day computational systems, however, are lacking in resilience and robustness in this respect. Whenever different components with different vocabularies and models of meaning interact within distributed, open enviroments, they have to rely on their human designers’ abilities t ...
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7
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TERMINÉ
Long-term effects of early nutrition on later health (EARLYNUTRITION)
Date du début: 1 févr. 2012, Date de fin: 31 oct. 2017,
Nutrition during early development has an important impact on later health, particularly through greater obesity risk, as demonstrated by FP6 EARNEST. EarlyNutrition explores the current key hypotheses on likely causes and pathways to prevention of early life origins of obesity (specifically adiposity) and associated disorders. We bring extraordinary expertise and study populations of 470,000 indi ...
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40
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TERMINÉ
Model-based preclinical development of anti-tuberculosis drug combinations (PREDICT-TB)
Date du début: 1 mai 2012, Date de fin: 30 oct. 2017,
Drug development in TB requires new integrated methods to transition the novel combination regimens needed to shorten first-line therapy and combat multi-drug resistance. Although new agents are emerging, the path to registration of such regimens remains uncertain while capacity for pivotal trials is limited. Selection and optimization of drug combinations for development depends on preclinical sy ...
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23
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TERMINÉ
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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32
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TERMINÉ
A novel generation of skin substitutes to clinically treat a broad spectrum of severe skin defects (EUROSKINGRAFT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem is far from being solved. The main challenge encountered is that most autologous skin grafting techniques are based on transplanting split-thickness skin (the today’s go ...
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11
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TERMINÉ
Transitioning towards Urban Resilience and Sustainability (TURAS)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
The “TURaS” project aims to bring together urban communities, researchers, local authorities and SMEs to research, develop, demonstrate and disseminate transition strategies and scenarios to enable European cities and their rural interfaces to build vitally-needed resilience in the face of significant sustainability challenges. To ensure maximum impact, the TURaS project has developed an innovati ...
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34
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TERMINÉ
The MEtabolic Road to DIAstolic Heart Failure (MEDIA)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,
More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements c ...
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23
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TERMINÉ
Sarcomere based Signals in Muscle Remodelling (SARCOSI)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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14
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TERMINÉ
Sustainable prevention of obesity through integrated strategies (SPOTLIGHT)
Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,
BACKGROUNDThe prevalence of overweight and obesity in Europe is high and contribute to mortality and the burden of many chronic diseases, especially within groups of lower social-economic status. Obesity is largely determined by modifiable lifestyle dependent risk factors such as reduced physical activity, sedentary behaviour and an unhealthy diet. There is growing evidence that influences on indi ...
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16
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TERMINÉ
Predictive Genomic Biomarkers Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer (ANGIOPREDICT)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,
In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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12
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TERMINÉ
Effective Communication in Outbreak Management: development of an evidence-based tool for Europe (E-COM@EU)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,
Although scientific knowledge to respond to outbreaks has increased, deficiencies remain in the ability of health authorities to communicate the need for large-scale measures such as vaccination and antiviral therapy and increase its acceptance. For effective behavioural and communication strategies, integration is needed of social, behavioural, communication and media sciences.We bring together t ...
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13
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TERMINÉ
Developmental neurotoxicity assessment of mixtures in children (DENAMIC)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. ...
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18
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TERMINÉ
Integrated non-CO2 Greenhouse gas Observing System (INGOS)
Date du début: 1 oct. 2011, Date de fin: 31 déc. 2015,
InGOS will support and integrate the observing capacity of Europe for non-CO2 greenhouse gases (NCGHG: CH4, N2O, SF6, H2 and halocarbons). The emissions of these gases are very uncertain and it is unknown how future climate change will feedback into the land use coupled emissions of CH4 and N2O. The NCGHG atmospheric abundances will increase further in the future and the emissions of these gases a ...
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39
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TERMINÉ
Building data bridges between biological and medical infrastructures in Europe (BIOMEDBRIDGES)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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26
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TERMINÉ
Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE) (PHENOTYPE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Indications exist that close contact with nature brings benefits to human health and well-being. The proposed work will investigate the interconnections between exposure to natural outdoor environments, in both rural and urban settings, and better human health and well-being in the North West, South and East of Europe. The project will explore the underlying mechanisms at work (stress reduction/re ...
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13
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TERMINÉ
Systems Networks Norms (SYSNORM)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,
Genomic sciences are driving progress in biology at an unprecedented pace, most recently through third-generation sequencing and synthetic biology. These achievements challenge commonly accepted biological concepts and assumptions in the humanities. In this Fellowship I will investigate the impact of genomic sciences on theory development in the social and human sciences, with focus on philosophy ...
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4
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TERMINÉ
Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI)
Date du début: 1 mars 2010, Date de fin: 31 déc. 2015,
Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine ex ...
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18
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TERMINÉ
European Training and Research in Peritoneal Dialysis (EUTRIPD)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,
Peritoneal dialysis (PD) and haemodialysis (HD) are life-saving renal replacement therapies for more than 200,000 patients with chronic kidney disease in Europe, and this number increases annually. Although PD and HD have similar mortality rates, PD offers major advantages in terms of quality of life, costs, home-based treatment opportunities and early patient survival. Moreover, PD, rather than H ...
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13
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TERMINÉ
The Integrated Initiative of European Laser Research Infrastructures III (LASERLAB-EUROPE)
Date du début: 1 juin 2012, Date de fin: 30 nov. 2015,
LASERLAB-EUROPE III is the European Consortium of major Laser Research Infrastructures, forming a FP7 Integrated Infrastructure Initiative. Geographically it covers the majority of European member states, following recent efforts to include partners from all over Europe 27. Scientifically, it covers many areas of laser science and applications with particular emphasis on short-pulses and high-inte ...
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26
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TERMINÉ
Choosing Efficient Combinations of Policy Instruments for Low-carbon development and Innovation to Achieve Europe's 2050 climate targets (CECILIA2050)
Date du début: 1 sept. 2012, Date de fin: 31 oct. 2015,
Europe needs to transform itself to a low-carbon economy by mid-century. The existing instrument mix needs to be scaled up drastically to initiate the changes needed across the economy. As the scale and scope of instruments increases, their interaction becomes more important, as do constraints on the political, legal and administrative feasibility. To evaluate their efficiency and effectiveness, i ...
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12
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TERMINÉ
EVALUATING THE IMPACT OF STRUCTURAL POLICIES ON HEALTH INEQUALITIES AND THEIR SOCIAL DETERMINANTS AND FOSTERING CHANGE (SOPHIE)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
The need to deal with health inequalities is now on the agenda of key supranational institutions, such as the European Commission (EC). To tackle the so-called “causes of the causes of health inequity”, the focus should be put on structural policies, policies that – especially in the current times of financial and employment crisis – influence patterns of social stratification, living and working ...
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14
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TERMINÉ
REstoring rivers FOR effective catchment Management (REFORM)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
REFORM is targeted towards development of guidance and tools to make river restoration and mitigation measures more cost-effective and to support the 2nd and future River Basin Management Plans (RMBPs) for the WFD. Aims of REFORM are (1) to provide a framework for improving the success of hydromorphological restoration measures and (2) to assess more effectively the state of rivers, floodplains an ...
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28
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TERMINÉ
Transglutaminase in disease: a novel therapeutic target? (TRANSPATH)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
"TRANSPATH is a multisectorial Network designed to facilitate the exchange of knowledge and technology between 7 leading European research teams and 3 SME partners and 2 associate SME Partners involved in basic and applied research into transglutaminase (TG) related human diseases. Its ambitions are to accelerate the development of new strategies for the treatment and diagnosis of human diseases ...
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12
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TERMINÉ
Changing Permafrost in the Arctic and its Global Effects in the 21st Century (PAGE21)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
Permafrost is defined as ground that remains continuously at or below 0°C for at least two consecutive years; some 24% of the land surface in the northern Hemisphere is classified as permafrost. In the Northern high latitudes, strong warming has been observed over the recent decades, and climate models project strong future warming. A projected decline in the extent of permafrost will have a major ...
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20
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TERMINÉ
Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
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19
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TERMINÉ
Water Harvesting Technologies Revisited: Potentials for Innovations, Improvements and Upscaling in Sub-Saharan Africa (WHATER)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,
The WHaTeR project aims to contribute to the development of appropriate water harvesting techniques (WHTs). These WHTs should be sustainable under dynamic global and regional pressure, and strengthen rainfed agriculture, improve rural livelihood and increase food production and security in Sub-Saharan Africa. In total 3 European and 5 African organisations will be involved; namely VU University Am ...
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10
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TERMINÉ
Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance (OVER-MYR)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2015,
Multiple Myeloma (MM) is a currently incurable rare malignant plasma cell disease, which invariably relapses despite therapy. The objective of OVER-MYR is to understand the causes of drug resistance and relapse, develop novel strategies to overcome these, provide proof of principal for phase I/II trial, and thus impact on MM-patient’s survival.Currently-used drugs target both MM cells (MMC) and c ...
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11
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TERMINÉ
Systems Analysis Tools Framework for the EU Bio-Based Economy Strategy (SAT-BBE)
Date du début: 1 oct. 2012, Date de fin: 31 mars 2015,
One of the biggest challenges facing global society today is the provision of food, water, energy, healthcare and other resources and services to a world that will see its population increase by a third in the face of mounting environmental stresses over the next 20 years. SAT-BBE studies the contribution of a bioeconomy in many of these areas to ensure long term economic and environmental sustain ...
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10
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TERMINÉ
Optimality Principles in Human Motor Control (OPT)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2015,
"Understanding how the brain controls even the simplest movement is a major challenge due to the bewildering complexity of the sensorimotor and musculoskeletal system. For example, the large number of joints and muscles provide the human musculoskeletal system with numerous degrees of freedom. As such, any motor task can be achieved via an infinite number of different muscle activation patterns. ...
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3
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TERMINÉ
Biomimetic nano-fiber-based nucleus pulposus regeneration for the treatment of degenerative disc disease (NPMimetic)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
"The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a pr ...
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12
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TERMINÉ
Employment 2025: How will multiple transitions affect the European labour market (NEUJOBS)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
The objective of NEUJOBS is to imagine future, or rather various possible futures, under the conditions of the socioecological transition (and incorporating other key influences), map the implications for employment overall, but also in key sectors and relevant groups and integrate all of this together under a single intellectual framework. It will do so by combining EU-wide studies based on exist ...
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31
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TERMINÉ
IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
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14
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TERMINÉ
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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19
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TERMINÉ
Synergising INTERnational Studies of Environmental Contamination with Organic FLAME Retardant Chemicals (INTERFLAME)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,
"INTERFLAME aims to enhance scientific understanding of how and to what extent organic flame retardant (FR) chemicals present in consumer goods and materials contaminate the environment, with particular reference to humans and wildlife. INTERFLAME’s twin foci are exposure arising from indoor contamination and monitoring the efficacy of recent actions designed to reduce environmental levels. Recent ...
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