6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Cell signaling pathways and epigenetic mechanisms controlling the differentiation of medullary thymic epithelial cells, key mediators in the induction of central self-tolerance (SIGnEPI4Tol)
Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,
Immunological tolerance is essential in preventing autoimmunity. The establishment of T-cell tolerance is induced in the thymus mainly by the deletion of hazardous autoreactive T cells. Medullary thymic epithelial cells (mTECs) are critical in this process because they express a diverse repertoire of peripheral tissue-restricted self-antigens (TRAs). Hazardous developing T-cells recognizing these ...
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TERMINÉ
Novel somatic mutations in ABCA1 in chronic myelomonocytic leukaemia (NOVAMOLE)
Date du début: 1 juin 2014, Date de fin: 31 mai 2018,
"Background: Altered high-density lipoprotein (HDL)-cholesterol homeostasis has been observed in hematologic malignancies but genetic evidences proving causality have been lacking. The ability of HDL to promote cholesterol efflux depends on two ATP-binding cassette transporters ABCA1 and ABCG1, which exhibit anti-myeloproliferative activity in preclinical mouse models.Hypothesis: Somatic mutations ...
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TERMINÉ
Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens (MeTaPATH)
Date du début: 2 sept. 2014, Date de fin: 1 sept. 2016,
"""Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens""Control of pathogen infection requires the generation of a tightly regulated immune response that recognizes the invading pathogen and that limits a potentially harmful host response. Recent work highlighted that resident memory T cells (TRM) form a very potent means of establishin ...
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TERMINÉ
TARGETING TUMOUR ASSOCIATED MACROPHAGES IN CANCER (TMAC)
Date du début: 1 déc. 2010, Date de fin: 30 nov. 2015,
There is increasing evidence that the body s ability to mount an immune response to cancer cells may dictate which patients are cured of cancer by conventional therapy. Macrophages have a central role in both innate and adaptive immunity; both human and experimental cancers become infiltrated by macrophages, however tumour-associated macrophages (TAM) are corrupted by the tumour microenvironment t ...
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TERMINÉ
Membrane sensors in the Arf orbit (ARFMEMBRANESENSORS)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2015,
Cellular organelles are continuously remodelled by numerous cytosolic proteins that associate transiently with their lipid membrane. Some distort the bilayer, others change its composition, extract lipids or bridge membranes at distance. Previous works from my laboratory have underlined the importance of membrane sensors, i.e. elements within proteins that help to organize membrane-remodelling eve ...
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TERMINÉ
Development of targeted DNA-Chips for High Throughput Diagnosis of NeuroMuscular Disorders (NMD-Chip)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2011,
Inherited Neuromuscular Diseases (NMD) form a large group of diseases including Limb-Girdle Muscular Dystrophies (LGMD), Congenital Muscular Dystrophies (CMD), Duchenne and Becker Muscular Dystrophies (DMD/BMD), or Charcot-Marie-Tooth disease (CMT). Within a given disease group genetic and clinical heterogeneity is the hallmark. The precise diagnostic of neuromuscular diseases thus requires extens ...
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