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TERMINÉ
Uncovering the mechanism and physiological relevance of myosin-VI-dependent AMPA receptor trafficking in neurons (MeReMy6)
Date du début: 1 août 2012, Date de fin: 31 juil. 2016,
The proper trafficking of membranes and associated proteins in neurons is crucial for the function of the nervous system. Myosin-VI is an actin-based cytoskeletal motor that promotes membrane trafficking and is suggested to play crucial roles in neurons. Most notably, the myosin affects the intracellular trafficking of AMPA receptors, major neurotransmitter receptors composed of transmembrane prot ...
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TERMINÉ
Pathogenetic mechanisms of depression in multiple sclerosis (Depression in MS)
Date du début: 1 sept. 2010, Date de fin: 31 août 2014,
Depression is one of the most common symptoms in patients with multiple sclerosis (MS) with a prevalence of up to 50%. Depression is linked to decreased cognitive function, lower quality of life, increases psychosocial and economic burden and is the strongest predictor of suicide.Despite the high clinical relevance, the pathogenetic substrates for depression in MS are poorly understood. Growing ev ...
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