12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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12
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TERMINÉ
Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)
Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,
Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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17
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TERMINÉ
PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,
Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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18
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TERMINÉ
Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,
Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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22
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TERMINÉ
Orphans Unite: chILD better together – European Management Platform for Childhood Interstitial Lung Diseases (CHILD-EU)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,
Children with diffuse lung disease, also called childhood interstitial lung diseases (chILD), may have one of more than 200 entities, the biggest group of respiratory orphan lung diseases. Frequently undiagnosed because of lack of awareness or complex differential diagnosis, they lead to much morbidity, mortality (about 15%) and psychosocial stress for the families. Current lack of evidence based ...
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10
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TERMINÉ
Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)
Date du début: 1 oct. 2011, Date de fin: 31 mars 2016,
Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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31
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TERMINÉ
Neuronal NanoCarbon Interfacing Structures (NeuroCare)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,
NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) a ...
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14
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TERMINÉ
The role of Toll-Like Receptors Signaling in Angiogenesis and its Potential Applications in Promoting Vascularization in Regenerative Medicine (RTSAPA)
Date du début: 15 janv. 2013, Date de fin: 14 janv. 2015,
"The creation of adequate tissue constructs and other therapeutic products in tissue engineering and regenerative medicine is a highly challenging task. Adequate vascularization of tissue engineering constructs is an important prerequisite, which could be promoted by allowing stem cells or progenitor cells to reach the site of injury/replacement for tissue repair. The development of new approaches ...
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1
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TERMINÉ
Silica-based Nanobiomedical Approaches for Treatment of Bone Diseases: Proof-of-Concept (SI-BONE-POC)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2013,
Silicatein is a unique enzyme from siliceous sponges that is able to catalyze the formation of an inorganic material, silica or “biosilica” which forms the inorganic skeleton of these sponges. Another exceptional property of this protein is its dual function, as we discovered for the first time in the ERC Advanced Grant “BIOSILICA” (Grant no. 268476): silicatein both (i) acts as an enzyme (biosili ...
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1
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TERMINÉ
Sponge Enzymes and Cells for Innovative AppLications (SPECIAL)
Date du début: 1 déc. 2010, Date de fin: 30 nov. 2013,
"The SPECIAL project aims at delivering breakthrough technologies for the biotechnological production of cellular metabolites and extracellular biomaterials from marine sponges. These include a platform technology to produce secondary metabolites from a wide range of sponge species, a novel in vitro method for the production of biosilica and recombinant technology for the production of marine coll ...
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11
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TERMINÉ
Microbial-induced Angiogenesis in the Gut (MicAG)
Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,
Objective: The mammalian gut is colonized by trillions of bacteria. These gut microbes (microbiota) have coevolved with the host and developed traits that affects host physiology. Interestingly, germ-free (GF) mice exhibit arrested intestinal vascularisation if compared to littermates that were raised in a non-sterile environment (CONV-R, conventional-raised). Intestinal colonization with a normal ...
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2
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TERMINÉ
Search for new therapeutic agents against complicated obesity by reprofiling existing drugs (REPROBESITY)
Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,
"Obesity is one of the most serious and fast-growing health problem in the European Union, and a leading cause of diabetes. The main barrier for approval of an anti-obesity drug is the safety requirements. We propose to overcome this barrier by discovering phenotypes and biomarkers that identify subsets of patients with safe and efficacious responses to drugs, and by identifying new indications of ...
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