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Probing the sequence determinants of ion channel voltage sensing via computation: towards the design of custom-tailored voltage-sensing modules (VOLTSENS)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2016,
Voltage sensing is a crucial property for a variety of proteins involved in many physiological functions (selective ion transport through membranes, enzymatic catalysis…). All these proteins achieve voltage sensing through the action of a 4 alpha-helix bundle module called the voltage-sensor domain (VSD). This transmembrane module achieves its function thanks to specific features, such as the pres ...
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