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Plus de 40 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra ...
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 17

 TERMINÉ 

Towards integrated management of freshwater Nature 2000 sites and habitats (FRESHABIT)

Date du début: 1 janv. 2016, Date de fin: 30 sept. 2022,

Background Freshwater habitats are among the most threatened habitat types globally. In the 2007-2012 conservation status assessment of the EU Habitats Directive (Article 17), none of the freshwater, coastal, and groundwater dependent wetland habitats in Europe fully met favourable conservation status, and most are in unfavourable conservation status. Alm ...
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 30

 TERMINÉ 

Hydrogen Mobility Europe 2 (H2ME 2)

Date du début: 1 mai 2016, Date de fin: 30 juin 2022,

Hydrogen Mobility Europe 2 (H2ME 2) brings together action in 8 European countries to address the innovations required to make the hydrogen mobility sector truly ready for market. The project will perform a large-scale market test of hydrogen refuelling infrastructure, passenger and commercial fuel cell electric vehicles operated in real-world customer applications and demonstrate the system bene ...
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 37

 TERMINÉ 

Language bootstraps cognitive complexity (LANGBOOT)

Date du début: 1 juin 2017, Date de fin: 31 mai 2022,

Language and cognition have a close, but cryptic, relationship. Is language just another tool in humans' diverse cognitive toolkit; vital for communication, but not necessary for complex, high-level thought? Or is language what allows us to form and manipulate complex thoughts in the first place, by allowing words to act as placeholders in ideas that would otherwise be too unwieldy to handle? Dist ...
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 1

 TERMINÉ 

Reputation Matters in the Regulatory State: Re-thinking the Fundamentals of Regulatory Independence, Credibility and Accountability (RICA)

Date du début: 1 juin 2017, Date de fin: 31 mai 2022,

RICA will fundamentally challenge, reconceptualise and redefine core foundational assumptions of the regulatory state. Arm’s length governance and regulatory independence have become the cornerstone normative and institutional design principles of the European regulatory state. Regulatory credibility is premised on agency insulation from politics with major systemic implications in the form of a r ...
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 1

 TERMINÉ 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 TERMINÉ 

Technology Evolution in Regional Economies (TechEvo)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

The creation and accumulation of knowledge are processes at the heart of technological change and economic growth. Attention has been directed at aggregate measures of knowledge production in regional and national contexts, but little consideration has been given to the properties of knowledge produced in specific places. How does the nature of knowledge that is produced vary over space, what cond ...
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 1

 TERMINÉ 

Bond activation and catalysis with low-valent aluminium (AlCat)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

This project will develop the principles required to enable bond-modifying redox catalysis based on aluminium by preparing and studying new Al(I) compounds capable of reversible oxidative addition.Catalytic processes are involved in the synthesis of 75 % of all industrially produced chemicals, but most catalysts involved are based on precious metals such as rhodium, palladium or platinum. These me ...
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 1

 TERMINÉ 

Quantifying the link between weathering and past CO2 levels (CONTROLPASTCO2)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

The carbon cycle is a vital aspect of our planet’s well-being. However, there are fundamental aspects of it that we do not understand, without which we cannot accurately quantify CO2 budgets. How, and at what rate, does the carbon cycle respond to, and recover from, events of rapid and extreme global warming or cooling? What process has maintained the climate within a habitable range for billions ...
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 1

 TERMINÉ 

High-Pressure High-Temperature Superconductivity (HPSuper)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Superconductors promote electrical currents without loss and are exploited for applications like magnets in medical imaging. Further applications like large scale usage in electrical power generation and transmission, however, are limited by the need to cool materials below a critical temperature Tc. Thus, novel superconductors with higher Tc are highly desirable.High Tc has been predicted almost ...
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 1

 TERMINÉ 

Understanding creativity and problem solving through sleep-engineering (SolutionSleep)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Innovative problem solving is critical for all spheres of organised endeavour, including science and industry, and thus forms the cornerstone of a successful society. Such creative thinking often requires suppression of preconceptions and restructuring of existing knowledge. Pioneering work has shown that sleep facilitates problem solving, but exactly how, and which sleep characteristics are imp ...
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 1

 TERMINÉ 

Structured nonlinear Metamaterials for efficient generation and Active functional control of Radiation of THz light (SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The terahertz optical regime, covering the long wavelength end of the optical spectrum, has been for many years the least explored spectral regime. Recent interest in this regime has led to important emerging applications spanning many disciplines including medical, biological, materials sciences, communications, security, and basic sciences. However, advances in these emerging applications are he ...
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 1

 TERMINÉ 

Federation for FIRE Plus (Fed4FIREplus)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The Fed4FIRE+ project has the objective to run and further improve Fed4FIRE’s “best-in-town” federation of experimentation facilities for the Future Internet Research and Experimentation initiative. Federating a heterogeneous set of facilities covering technologies ranging from wireless, wired, cloud services and open flow, and making them accessible through common frameworks and tools suddenly op ...
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 24

 TERMINÉ 

SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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 18

 TERMINÉ 

Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic an ...
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 16

 TERMINÉ 

AnTBiotic – progressing TB drug candidates to clinical proof of concept (anTBiotic)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Tuberculosis (TB) today rivals HIV/AIDS as the leading cause of death from infectious diseases. The number of TB patients has never been higher and the growing proportion of drug-resistant TB is threatening control strategies both in the developing and developed world, Eastern Europe being a particularly worrying point in case. The anTBiotic consortium aims to fuel the long-term TB clinical pipeli ...
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 5

 TERMINÉ 

Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention ...
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 9

 TERMINÉ 

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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 17

 TERMINÉ 

Early-life stressors and LifeCycle health (LIFECYCLE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur ...
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 19

 TERMINÉ 

Fostering responsive mental health systems in the Syrian refugee crisis (STRENGTHS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

STRENGTHS aims to provide effective community-based health care implementation strategies to scale-up the delivery and uptake of effective mental health interventions in different country contexts. The current refugee crisis across Europe and the Middle East effects both individual refugees’ psychological well-being, as they face extreme stressors in their flight from their home country, but also ...
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 15

 TERMINÉ 

Strengthening management at district level to support the achievement of Universal Health Coverage (PERFORM2scale) (Perform 2 scale)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The new challenge in global health is to achieve Universal Health Care (UHC) by 2030. Having an adequate workforce is critical to achieving UHC. Efforts are in place to scale up the numbers of health workers. Improving health workforce performance is equally important as the quantity of health workers, but more challenging. Workforce performance improvement can be achieved better at management ...
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 7

 TERMINÉ 

Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa: An implementation research (SPICES Project) (SPICES)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall research objective of the SPICES project is to implement and evaluate a comprehensive CVD prevention and control program in five settings: a rural & semi-urban community in a low-income country (Uganda), middle income (South Africa) and vulnerable groups in three high-income countries (Belgium, France and United Kingdom) as well as to identify and compare the barriers and facilitators ...
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 6

 TERMINÉ 

Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection (HIVACAR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planne ...
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 16

 TERMINÉ 

EUROlinkCAT: Establishing a linked European Cohort of Children with Congenital Anomalies (EUROlinkCAT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Over 130,000 children born in Europe every year will have a congenital anomaly (CA; birth defect). These CAs, which are often rare diseases, are a major cause of infant mortality, childhood morbidity and long-term disability. EUROCAT is an established European network of population-based registries for the epidemiologic surveillance of CAs. EUROlinkCAT will use the EUROCAT infrastructure to suppor ...
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 25

 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 TERMINÉ 

Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial (PAPA-ARTIS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

 TERMINÉ 

Restoration of sterlet populations in the Austrian Danube (LIFE Sterlet)

Date du début: 1 sept. 2015, Date de fin: 31 déc. 2021,

Background The sterlet (Acipenser ruthenus) is the smallest species of the Danube sturgeons and resides for its whole lifecycle in freshwater without the need to migrate to the Black Sea. Sterlets are still present in very small quantities in the Upper Danube whereas the large anadromous sturgeon species became extinct in the last century due to overfishi ...
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 3

 TERMINÉ 

Transparent p-type semiconductors for efficient solar energy capture, conversion and storage. (p-TYPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This proposal will develop new transparent p-type semiconductors that will make dye-sensitized solar cells (DSC) a vastly more efficient and a realistic prospect for carbon-free energy generation worldwide. Two key challenges will be addressed: (1) a means of converting NIR radiation to increase the amount of sunlight utilised from 35% to over 70%; (2) a means of storing the energy. Almost all the ...
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 2

 TERMINÉ 

The New Politics of Welfare: Towards an “Emerging Markets” Welfare State Regime (EmergingWelfare)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This research project aims to identify a new welfare regime in emerging market economies and explain why it has emerged. The project will compare Brazil, China, India, Indonesia, Mexico, South Africa and Turkey to test two hypotheses: (i) emerging market economies are forming a new welfare regime that differs from liberal, corporatist and social democratic welfare regimes of the global north on th ...
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 1

 TERMINÉ 

Novel Mechanism of Behavioural Change (ChangeBehavNeuro)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Understanding how values of different options that lead to choice are represented in the brain is a basic scientific question with far reaching implications. I recently showed that by the mere-association of a cue and a button press we could influence preferences of snack food items up to two months following a single training session lasting less than an hour. This novel behavioural change manipu ...
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 1

 TERMINÉ 

A Global Anthropology of Transforming Marriage (AGATM)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This research will create a new theoretical vision of the importance of marriage as an agent of transformation in human sociality. Marriage globally is undergoing profound change, provoking intense debate and anxiety. These concerns refract wider instabilities in political, economic, and familial institutions. They signal the critical role of marriage in bringing together - and separating - intima ...
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 1

 TERMINÉ 

Power of Algorithms in Discrete Optimisation (PowAlgDO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Convex relaxations, such as linear and semidefinite programming, constitute one of the most powerful techniques for designing efficient algorithms, and have been studied in theoretical computer science, operational research, and applied mathematics. We seek to establish the power convex relaxations through the lens of, and with the extensions of methods designed for, Constraint Satisfaction Proble ...
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 1

 TERMINÉ 

SHARING A GENOME: CASTE ANTAGONISM AND COADAPTATION IN SOCIAL INSECTS (CASTECON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Eusociality, in which workers sacrifice their own reproduction to rear the offspring of queens, is a major focus of interest in evolutionary biology. A key aim during recent decades has been to understand the conflicts of interest within eusocial groups. In contrast, however, little is known about the underlying genetic architecture. In this proposal, we will use a mixture of field experiments and ...
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 1

 TERMINÉ 

Quantum spin simulators in diamond (Q-DIM-SIM)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Quantum interacting systems are at the forefront of contemporary physics, and pose challenges to our understanding of quantum phases, many-body dynamics, and a variety of condensed matter phenomena. Advances in quantum applications, including quantum computation and metrology, rely on interactions to create entanglement and to improve sensitivity beyond the standard quantum limit. In recent years ...
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 1

 TERMINÉ 

Functional Systems of Capsules (FunCapSys)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The simplest living organism is composed of myriad chemical subsystems, each consisting of structurally complex biomolecules that interact in many ways; the properties of life emerge from these dense connections. Understanding how these interactions take place will help elucidate the foundations of biology, as well as enabling the design and creation of new chemical networks with targeted function ...
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 1

 TERMINÉ 

Quantum electronic states in delafossite oxides (QUESTDO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

One of the most active challenges of modern solid state physics and chemistry is harnessing the unique and varied physical properties of transition-metal oxides. From improved electrodes for solar cells to loss-less transmission of power, these compounds hold the potential to transform our daily lives. Subtle collective quantum states underpin their diverse properties. These complicate their ph ...
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 1

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

An integrated approach to understanding the impact of de novo mutations on the mammalian genome (DENOVOMUT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Understanding the process of spontaneous mutation is fundamental for understanding the genetic basis of quantitative variation, the threat posed by declining population size in conservation biology and the distribution of nucleotide variation in the genome. I will address these and other unanswered questions concerning the evolutionary impact of spontaneous mutation using the house mouse as a mode ...
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 2

 TERMINÉ 

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

 TERMINÉ 

Warwick Interdisciplinary Research Leadership Programme (WIRL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The Warwick Interdisciplinary Research Leadership Programme (WIRL) is a major new initiative by the University of Warwick to train future generations of Research Leaders in Europe. Warwick is known for its experience in interdisciplinary postdoctoral training through its leading Institute of Advanced Study (IAS), its innovative cross-sectoral research carried out through its ten Global Research Pr ...
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 1