16 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy (SyBil-AA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Alcohol addiction ranks among the primary global causes of preventable death and disabilities in human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Within this project, we will utilize a translational approach based on clinical studies and animal experiments to fill thi ...
Voir le projet
13
Participants partenaires
TERMINÉ
Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
Voir le projet
21
Participants partenaires
TERMINÉ
Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
Voir le projet
27
Participants partenaires
TERMINÉ
IMAging GEnetics for MENtal Disorders (IMAGEMEND)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research literature exists, few neuroimaging applications have reached clinical practice in psychiatry. A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. I ...
Voir le projet
15
Participants partenaires
TERMINÉ
"Training in neurodegeneration, therapeutics intervention and neurorepair" (TINTIN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Dopamine neurons play a central role in major illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementia. A multidisciplinary approach must be taken by European researchers to discover the molecular basis of dopamine neurodegeneration and how new technologies will lead to repair and regeneration of neuronal systems in the b ...
Voir le projet
8
Participants partenaires
TERMINÉ
Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes (TACTICS)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2017,
Compulsivity is characterized by a repetitive, irresistible urge to perform a behavior, the experience of loss of voluntary control over this intense urge, the diminished ability to delay or inhibit thoughts or behaviors, and the tendency to perform repetitive acts in a habitual or stereotyped manner. Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders t ...
Voir le projet
13
Participants partenaires
TERMINÉ
Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
Voir le projet
46
Participants partenaires
TERMINÉ
Pharmacogenomic biomarkers as clinical decision making tools for clozapine treatment of schizophrenia (CRESTAR)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
Treatment resistant schizophrenia (TRS) is the most disabling of all psychiatric illnesses, affecting about 1/3 of patients (~1 million Europeans), a considerable economic and social burden. First-line treatments include atypical (e.g. olanzapine) and typical (e.g. haloperidol) antipsychotics. The original atypical, clozapine, is a final option, and although it is the only antipsychotic shown to b ...
Voir le projet
11
Participants partenaires
TERMINÉ
European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,
The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interaction ...
Voir le projet
27
Participants partenaires
TERMINÉ
Suicidality: Treatment Occurring in Paediatrics (STOP)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
Voir le projet
19
Participants partenaires
TERMINÉ
THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA (LIPIDIDIET)
Date du début: 1 août 2008, Date de fin: 31 mars 2015,
Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of the ...
Voir le projet
19
Participants partenaires
TERMINÉ
Optimizing suicide prevention programs and their implementation in Europe (OSPI-Europe)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,
Suicide is a serious public health problem in the EU calling for effective interventions. The aim of this project is to provide EU member states with an evidence based prevention concept, concrete materials and instruments for running and evaluating these interventions and recommendations for the proper implementation of the intervention. These aims will be achieved by the following objectives: &g ...
Voir le projet
15
Participants partenaires
TERMINÉ
Genomic variations underlying common behavior diseases and cognition trait in human populations (ADAMS)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,
"The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated wi ...
Voir le projet
12
Participants partenaires
TERMINÉ
Copy number variations conferring risk of psychiatric disorders in children (PsychCNVs)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,
The recent technical improvements for the study of the cytogenetic basis of disease have led to the identification of many microdeletion and microduplication syndromes. De novo copy number variants (CNVs) are seen more often than expected in autistic patients, and rare chromosomal aberrations are known to account for a small fraction of schizophrenia and bipolar disorder. Recurrent spontaneous mut ...
Voir le projet
8
Participants partenaires
TERMINÉ
Developing minimally invasive, tools and technologies for high throughput, low cost molecular assays for the early diagnosis of schizophrenia and other psychiatric disorders (SchizDX)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
Schizophrenia and bipolar affective disorder are a major burden to affected individuals and their families and to society at large. These two severe mental illnesses affect at least 2% of the population worldwide, and whilst 50% of sufferers do not receive adequate treatment, they cost hundreds of billions in healthcare provision, treatments and lost earnings. The current diagnosis of schizophreni ...
Voir le projet
9
Participants partenaires
TERMINÉ
Learning in Motion - Outdoor Education for Adults with Intellectual Disabilities or Mental Illness
Date du début: 1 oct. 2004,
The Learning in Motion (LIM) project aimed to explore the use of the outdoors as a stimulus for learning for adults with intellectual disabilities and/or with a history of mental illness. In addition to the obvious physical-health benefits, outdoor learning aimed at increasing the intellectual capacity of participants through developing basic skills in reading, writing and numerical understanding. ...
Voir le projet