9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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14
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TERMINÉ
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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13
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TERMINÉ
"""RNPnet"" - RNP structure, function and mechanism of action" (RNPNET)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and h ...
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15
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TERMINÉ
Proteomics Research Infrastructure Maximising knowledge EXchange and access (XS) (PRIME-XS)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
Genome sequencing initiated a new age in biology. Now, the emphasis is on the biological interpretation of the genome: zooming on the biological functioning of the gene-products, i.e. the proteins, emerging into a filed termed proteomics. Protein levels depend not only on mRNA levels, but also on translational controls & regulated degradation, making the measurement of expression at the protein le ...
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12
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TERMINÉ
Cytoskeleton architecture in host cells during Listeria infection using cryo-electron tomography (3DCELLART)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2013,
"Bacterial infection into host cells is an important and highly active field of research. Understanding the interactions and the distribution of the host-cell scaffolding protein network during bacterial entry poses a major challenge. The molecular architecture of actin comet tails, filamentous structures assembled by internalized bacteria to move inside the host-cell cytoplasm and from cell-to-ce ...
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1
Participant partenaire
TERMINÉ
Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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17
Participants partenaires
TERMINÉ
Integrated Structural Biology Infrastructure (INSTRUCT)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,
Structural biology in the next two decades aims to integrate structural knowledge at different resolution levels into specific cellular contexts, with a temporal component, to underpin biomedical sciences. This challenge requires the seamless integration of techniques providing information in different resolution ranges. INSTRUCT will link the information obtained by the major structural biology ...
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15
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TERMINÉ
Understanding and fighting metastasis via dissection of the Core Invasive Machinery (MetaFight)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,
The co-operative Metafight project will perform functional studies to understand the dissemination and outgrowth of metastasis through systematic analysis of the Core Invasive Machinery contained within integrin-mediated ECM attachment structure. It includes a large and discretely localised intracellular signalling network which drives migration and invasion. Our strategy is based on the hypothesi ...
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10
Participants partenaires
TERMINÉ
Subunit localization of the Drosophila 26S proteasome by means of 3D cryo electron microscopy (26S PROTEASOME)
Date du début: 1 juin 2008, Date de fin: 31 mai 2010,
"In eukaryotic cells, the majority of cytosolic and nuclear proteins are degraded via the ubiquitin–proteasome pathway. Proteins carrying multiubiquitin tags are selected and degraded by the 26S proteasome, which is a large molecular assembly built from 30 different subunits.Two major components form the 26S complex: the proteolytic core particle (CP) and the regulatory particles (RPs).Whereas the ...
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