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Plus de 40 projets européens trouvés

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 TERMINÉ 

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease (CResPace)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, an ...
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 8

 TERMINÉ 

MEthane goes MObile - MEasurements and MOdelling (MEMO2)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

Mitigation of climate change is a key scientific and societal challenge and also a headline target of the EU2020 strategy. Strong reductions in greenhouse gas emissions are necessary to reach the global warming target agreed on at the 2015 United Nations Convention of Parties in Paris. Such emission reductions can only be achieved if sources are properly quantified and mitigation efforts are verif ...
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 9

 TERMINÉ 

Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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 19

 TERMINÉ 

MetaMaterials antenna for ultra-high field MRI (M-CUBE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

M-Cube aims at changing the paradigm of High-Field MRI and Ultra High-Field antennas to offer a much better insight on the human body and enable earlier detection of diseases. Our main objective is to go beyond the limits of MRI clinical imaging and radically improve spatial and temporal resolutions. The clinical use of High-field MRI scanners is drastically limited due to the lack of homogeneity ...
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 13

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment (in3)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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 13

 TERMINÉ 

Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 TERMINÉ 

circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particular ...
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 8

 TERMINÉ 

Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,

The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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 25

 TERMINÉ 

Innovation pathways, strategies and policies for the Low-Carbon Transition in Europe (INNOPATHS)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

The Paris Agreement substantially increased the need for countries and regions to understand the full economic, social and environmental implications of the deep decarbonisation to which the global community is now committed. The EU has long had decarbonisation ambitions, but there remains considerable uncertainty as to precisely how these ambitions will be achieved, or what the impacts of such ac ...
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 15

 TERMINÉ 

Realising Innovation in Transitions for Decarbonisation (REINVENT)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

It is high time for the EU to develop pathways and strategies for decarbonisation also in emissions intensive sectors such as steel, plastics, paper, and meat and dairy. These are sectors where low carbon transitions are still relatively unexplored. Some progressive companies and other actors are just beginning to consider such pathways. The overall aim of REINVENT is to help Europe achieve its lo ...
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 5

 TERMINÉ 

Connecting Patients and Carers using wearable sensor technology (NIGHTINGALE)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Safest, reliable, individualised care of patients at-risk of deterioration needs patients themselves to play an active role in their care whenever possible: late detection or escalation of deterioration causes avoidable harms, and deaths. In this project we will challenge industry to develop robust monitoring and communications systems that connect patients, carers and health professionals, provid ...
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 5

 TERMINÉ 

Educational Network in Ocular Drug Delivery and Therapeutics (OcuTher)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Ocular drug development has transformed from niche area to a major field in drug development in which many companies, including European big pharma has entered recently. Ocular drug development is a unique field in terms of drug targets and end-points of activity, local drug administration routes, tissue barriers and pharmacokinetics, drug delivery and formulation challenges and local toxicity iss ...
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 9

 TERMINÉ 

Nature Based Urban Innovation (NATURVATION)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Nature-Based Solutions (NBS) have the potential to respond to climate change, enhance biodiversity and improve environmental quality while contributing to economic regeneration and social well-being. Yet there is a substantial gap between the promise of NBS and their uptake. To unlock the potential of NBS for sustainable urban development, NATURVATION will take a transdisciplinary, internationally ...
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 14

 TERMINÉ 

Critical Heritage Studies and the Future of Europe_Towards an integrated, interdisciplinary and transnational training model in cultural heritage research and management (CHEurope)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

CHEurope focuses on developing a new integrated theoretical and methodological framework to enhance the academic and professional training and open future job opportunities in cultural heritage preservation, management and promotion. Heritage has commonly been perceived through its contingent relationship to other areas, preventing it to be considered as a ‘legitimate’ scientific discipline. Moreo ...
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 8

 TERMINÉ 

Reshaping society and space: home-based self-employment and businesses (WORKANDHOME)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

The aim of WORKANDHOME is to develop a new framework for understanding fundamental changes currently taking place to work that situates individuals as economic actors within the context of their wider life domains, household, home and neighbourhood. This will break new ground in how we understand and classify economic activity, the home, the firm, places of economic activity, labour markets and ‘r ...
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 4

 TERMINÉ 

European Training Network for the sustainable, zero-waste valorisation of (critical) metal containing industrial process residues (SOCRATES)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Unlike China, Russia or South Africa, the EU-28 Member States are not in the fortunate position of having vast, easily accessible ore deposits containing valuable metals. However, Europe does have large quantities of secondary industrial residues (tailings, sludges, slags and ashes) that contain sig¬nificant concentrations of both critical and economically important metals. The Euro¬pean Training ...
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 8

 TERMINÉ 

Tribbles Research and Innovation Network (TRAIN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects ...
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 10

 TERMINÉ 

New constraints on the Amazonian carbon balance from airborne observations of the stable isotopes of CO2 (ASICA)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Severe droughts in Amazonia in 2005 and 2010 caused widespread loss of carbon from the terrestrial biosphere. This loss, almost twice the annual fossil fuel CO2 emissions in the EU, suggests a large sensitivity of the Amazonian carbon balance to a predicted more intense drought regime in the next decades. This is a dangerous inference though, as there is no scientific consensus on the most basic m ...
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 5

 TERMINÉ 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 TERMINÉ 

HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making (HarmonicSS)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along wi ...
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 39

 TERMINÉ 

PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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 20

 TERMINÉ 

OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly (OPERAM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria ...
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 9

 TERMINÉ 

Training network providing cutting-EDGE knowlEDGE on Herpes Virology and Immunology (EDGE)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2020,

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunode ...
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 9

 TERMINÉ 

Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation (SponGES)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The objective of SponGES is to develop an integrated ecosystem-based approach to preserve and sustainably use vulnerable sponge ecosystems of the North Atlantic. The SponGES consortium, an international and interdisciplinary collaboration of research institutions, environmental non-governmental and intergovernmental organizations, will focus on one of the most diverse, ecologically and biologicall ...
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 19

 TERMINÉ 

Understanding subduction zone topography through modelling of coupled shallow and deep processes (SUBITOP)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The SUBITOP ETN is a framework for training and career development of young researchers in Geodynamics, Geophysics, Geology and Geomorphology. It has a scientific focus on the dynamics of continental margins where tectonic plates are recycled through subduction. Subduction processes have shaped and govern many aspects of the topography of Europe, and other continents, and they determine the patte ...
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 10

 TERMINÉ 

A multiscale approach towards mesostructured porous material design (MULTIMAT)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

"MULTIMAT addresses (1) the industrial and societal need for affordable materials that have a highly defined and large porosity together with the required (mechanical, chemical and/or thermal) robustness for application in thermal insulation, catalysts, fuel cells and oil spill remediation and (2) the scientific need to better understand the mechanisms underlying the assembly of small building blo ...
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 8

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

Inclusive Education and Social Support to Tackle Inequalities in Society (ISOTIS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

ISOTIS addresses the nature, causes and impact of early emerging social and educational inequalities in the context of socioeconomic, cultural and institutional processes. The aim is to contribute to effective policy and practice development to combat inequalities. Quasi-panels and pooled longitudinal datasets will be used to examine the variation in early educational gaps and developmental trajec ...
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 17

 TERMINÉ 

Tools and TECHNOlogies for Breakthrough in hEArt Therapies (TECHNOBEAT)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Cardiovascular diseases including myocardial infarction (MI), which entails the irreversible loss of heart muscle tissue, constitute a major socio-economic burden in global healthcare. With whole organ transplantation as the only treatment option for end-stage heart failure, MI patients could particularly benefit from advanced cell therapies aimed at the functional reconstitution of damaged hearts ...
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 8

 TERMINÉ 

Towards a European THeory Of juStice and fairness (ETHOS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

"ETHOS seeks to provide building blocks for the development of the an empirically informed European theory of justice by (a) refining and deepening the knowledge on the European foundations of justice - both historically based and contemporary envisaged; (b) enhancing the awareness of the mechanism that impede the realisation of the justice ideals that live in contemporary Europe; (c) advancing th ...
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 6

 TERMINÉ 

Political and sOcial awareness on Water EnviRonmental challenges (POWER)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2019,

POWER is a user-driven project to share knowledge and experience of water related issues in different EU local authorities to create a tool for EU water policy. It addresses four of the eight EIP WATER priorities:1. Water reduction consumption2. Water quality 3. Extreme weather events (surface water flood risk) 4. Variables related to water conservationIt will develop a common DSP sys ...
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 12

 TERMINÉ 

Combating Fiscal Fraud and Empowering Regulators (COFFERS)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

Since 2008 'fiscal leaks' have become an immediate policy challenge for EU governments, partly as a result of tax abuse. The COFFERS project unfolds as EU tax authorities transition to a new era in tackling tax abuse based upon policy innovation at the OECD, EU and national levels. COFFERS recognizes this creates a state of flux where much tax authority expertise regarding past regulations, system ...
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 9

 TERMINÉ 

EPOS Implementation Phase (EPOS IP)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

The nations of Europe are distributed around some of the most complex and dynamic geological systems on the planet and understanding these is essential to the security of livelihoods and economic power of Europeans. Many of the solutions to the grand challenges in the geosciences have been led by European scientists – the understanding of stratigraphy (the timing and distribution of layers of sedi ...
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 48

 TERMINÉ 

Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity (PolarNet)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell pola ...
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 9

 TERMINÉ 

Beyond EPICA - Oldest Ice (BE-OI)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2019,

To better constrain the response of Earth’s climate system to continuing emissions, it is essential to turn to the past. A key advance would be to understand the transition in Earth’s climate response to changes in orbital forcing during the 'mid-Pleistocene transition' (900 to 1200 thousand years ago) and in particular the role of greenhouse gases. Unravelling such key linkages between the carbon ...
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 14