Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,
IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra ...
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17
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TERMINÉ
A Systems medicine approach to chronic inflammatory disease (SYSCID)
Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,
"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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16
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TERMINÉ
Quantifying the link between weathering and past CO2 levels (CONTROLPASTCO2)
Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,
The carbon cycle is a vital aspect of our planet’s well-being. However, there are fundamental aspects of it that we do not understand, without which we cannot accurately quantify CO2 budgets. How, and at what rate, does the carbon cycle respond to, and recover from, events of rapid and extreme global warming or cooling? What process has maintained the climate within a habitable range for billions ...
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1
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TERMINÉ
SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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18
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TERMINÉ
Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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25
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TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
Extreme Citizen Science: Analysis and Visualisation (ECSAnVis)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
The challenge of Extreme Citizen Science is to enable any community, regardless of literacy or education, to initiate, run, and use the result of a local citizen science activity, so they can be empowered to address and solve issues that concern them. Citizen Science is understood here as the participation of members of the public in a scientific project, from shaping the question, to collecting t ...
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1
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TERMINÉ
Exploring new applications of amino acid covariation analysis in modelling proteins and their complexes (ProCovar)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
As a result of the rapid development of next generation sequencing, we now have access to hundreds and often many thousands of sequences which belong to the same family. Such a large amount of sequence data for a particular protein family, along with recent developments in computational statistics, enables an entirely new kind of evolutionary analysis to be performed on sequences, where for the fi ...
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1
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TERMINÉ
CHROMIUM
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Why the Universe is void of anti-matter is one of the remaining Big Questions in Science.One explanation is provided within the Standard Model by violation of Charge Parity (CP) symmetry, producing differences between the behavior of particles and their anti-particles.CP violation in the neutrino sector could allow a mechanism by which the matter-anti matter asymmetry arose.The objective of this p ...
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2
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TERMINÉ
Large-scale analysis of neuronal population activity (NEUROPOP)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The brain works through the activity of large, spatially distributed neuronal populations. Recent technological advances enable recordings of thousands of neurons from multiple brain structures, offering an unprecedented opportunity to understand neuronal population activity. However, mathematical and computational advances are also required to turn the resulting flood of data into concise princip ...
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1
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TERMINÉ
Policy analysis with beliefs about identifying restrictions (PABIR)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The principal tool for macroeconomic policy analysis both in the empirical literature and in actual practice at policy institutions is Structural Vector Autoregressions (SVARs). This research project aims to address the key controversy surrounding SVARs, namely the fact that the policy conclusions crucially depend on the choice of identifying restrictions. This choice is in practice arbitrary as t ...
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1
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TERMINÉ
Charge Carrier Transport in Soft Matter: From Fundamentals to High-Performance Materials (SOFTCHARGE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Charge transport (CT) in soft condensed matter is at the heart of many exciting and potentially revolutionising technologies ranging from organic photovoltaic cells to nanobioelectronic transistors. Tremendous progress has been made on these research frontiers over the last twenty years. Yet, our fundamental understanding of CT in organic and biological semiconductors (OBS) that could rationalise ...
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1
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TERMINÉ
A Neurocomputational Model of Episodic Memory (NEUROMEM)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Our memories define us, and their disruption in psychiatric and neurological conditions can be devastating. However, how we are able, e.g., to remember our wedding day and re-imagine the scene that was around us, remains one of the great mysteries of the human mind. NEUROMEM is an integrated experimental and computational attempt at a fundamental breakthrough in this problem. Building on recent in ...
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1
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TERMINÉ
Brain network based stratification of mental illness (STRATIFY)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcement–related be ...
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4
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TERMINÉ
IN-TOUCH: Digital Touch and Communication (IN-TOUCH)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The rapid expansion of digital touch technologies is set to reconfigure touch and the tactile in significant ways, much as optical technologies transformed sight and the visual. This has immense social significance for communication. There are, however, major gaps in our understanding of touch as it is digitally mediated, and methods are under-developed for a social account of digital touch commun ...
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1
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TERMINÉ
Frontiers in Mechanism Design: Methodology and Applications (Frontiers in Design)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Mechanism design is the engineering side of economics. Research findings in this field have helped governments and practitioners worldwide design better institutions: auctions that are more profitable or efficient; labour markets that improve the match between employees and employers; and better ways to assign students to public schools. The cornerstone of mechanism design is the revelation princ ...
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1
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TERMINÉ
SKILLPOV
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Our proposal is motivated by three main problems concerning the relationship between poverty and skill formation. First, recent research suggests that the main reason why schools in poor areas have low quality is because their teachers are ineffective. What is not known is how to identify an effective teacher, and whether we can compensate low quality teaching in early grades with high quality tea ...
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1
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TERMINÉ
Higgs bundles: Supersymmetric Gauge Theories and Geometry (HIGGSBNDL)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, t ...
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2
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TERMINÉ
Building Next-Generation Computational Tools for High Resolution Neuroimaging Studies (BUNGEE-TOOLS)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Recent advances in magnetic resonance (MR) acquisition technology are providing us with images of the human brain of increasing detail and resolution. While these images hold promise to greatly increase our understanding of such a complex organ, the neuroimaging community relies on tools (e.g. SPM, FSL, FreeSurfer) which, being over a decade old, were designed to work at much lower resolutions. Th ...
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1
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TERMINÉ
Recombination, sex-specific adaptation and evolution of the poeciliid sex chromosomes (GuppY)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
Sex chromosomes have evolved independently countless times throughout the eukaryotes. As such, sex chromosomes represent one of the most pervasive examples of convergent evolution, as analogous yet unrelated sex chromosomes share many unique features that distinguish them from the rest of the genome. Although models for sex chromosome evolution have been proposed, they have been difficult to empir ...
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1
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TERMINÉ
Clinical development and proof of principle testing of new regenerative VEGF-D therapy for cost-effective treatment of refractory anginaA phase II randomized, double-blinded, placebo-controlled study (ReGenHeart)
Date du début: 1 janv. 2017, Date de fin: 30 juin 2021,
Chronic angina pectoris is a debilitating chronic disease, a subgroup of these patients suffers from refractory angina which unfortunately can’t be controlled by medical therapy (angioplasty or surgery). Refractory angina is a substantial burden on the individual and healthcare system, in Europe there are 100,000 new cases per year, annual mortality of these patients is relatively low (
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10
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TERMINÉ
Citizens of photography: the camera and the political imagination (PHOTODEMOS)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
Citizens of photography: the camera and the political imagination will study a set of questions which recent transformations in political and photographic theory have made possible and which the current ‘war of images’ makes urgent and necessary.Recent conceptual work suggests that photography makes available a form of citizenry, a form of civil imagination that may be available in advance of conv ...
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1
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TERMINÉ
The origins of dendritic computation within mammalian neural circuits (DENDRITECIRCUITS)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
This proposal aims to address a simple question: what is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also if we are to build accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. In this proposal, ...
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1
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TERMINÉ
Bayesian Networks and Non-Rational Expectations (BAYNET)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
"This project will develop a new framework for modeling economic agents having "boundedly rational expectations" (BRE). It is based on the concept of Bayesian networks (more generally, graphical models), borrowed from statistics and AI. In the framework's basic version, an agent is characterized by a directed acyclic graph (DAG) over the set of all relevant random variables. The DAG is the agent's ...
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2
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TERMINÉ
Cold Atmospheric Molecules on a Chip (CAtMolChip)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
...decelerating, transporting and trapping these samples.With the support of this Consolidator Grant a new experimental research program will be developed in the Department of Physics and Astronomy at University College London involving laboratory based studies of (1) inelastic scattering processes, and (2) the decay mechanisms of gas-phase atmospheric molecules, including N2, O2 and NO, and their co ...
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1
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TERMINÉ
Supernova dust: production and survival rates (SNDUST)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
The dust content of galaxies is dominated by silicate and carbon grains, whose origin is the subject of much debate - are the dust grains provided mainly by red giant stars, by supernovae from massive stars, or can they grow in the interstellar medium itself from stardust seeds? My team's recent observations with Herschel of three supernova remnants, Cas A, SN 1987A and the Crab Nebula, have provi ...
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1
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TERMINÉ
Networks in Time and Space (NETS)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
This research programme aims to develop a new theoretical framework for modelling and analysing spatio-temporal networks. The theory developed in this programme will underpin our ability to exactly specify the structured form of network behaviour in time and space. This will advance statistical methodology and theory, unifying results from stochastic processes with network theory to do so. New tec ...
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1
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TERMINÉ
How retrotransposons remodel the genome during early development and reprogramming (TransposonsReprogram)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Retrotransposons (RTNs) are ancient viruses that have stably integrated themselves into mammalian genomes and they now occupy around half of the human or mouse genome. These mobile genetic elements that have coevolved with us drive evolution by creating new genes and plasticity of genomes. Exciting data including ours has shown that even RTNs that are no longer active retain enhancer, promoter or ...
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1
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TERMINÉ
DISCOVERER – DISruptive teChnOlogies for VERy low Earth oRbit platforms (DISCOVERER)
Date du début: 1 janv. 2017, Date de fin: 31 mars 2021,
We envision a radical redesign of Earth observation platforms for sustained operation at significantly lower altitudes than the current state of the art, using a combination of new aerodynamic materials, aerodynamic control and air-breathing electric propulsion for drag-compensation, for a variety of observation methods with the aim of creating a new platform paradigm.This vision requires foundati ...
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9
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TERMINÉ
Innovative Network for Monte Carlo Event Generators for LHC Physics (MCnetITN3)
Date du début: 1 avr. 2017, Date de fin: 31 mars 2021,
We propose a European Training Network that will provide a total of 540 ESR-months of training in Monte Carlo event generator physics and techniques, and related applications in experimental particle physics.Monte Carlo event generators are central to high energy particle physics. They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theo ...
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9
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TERMINÉ
Probabilistic Foundations for Networks (ProFoundNet)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
In an ever-connected world, increasingly complex network systems play a crucial role in many daily tasks. This results in an acute need for methods/tools that can enable easy control of the network and, at the same time, provide rigorous guarantees about its behavior, performance, and security. Recent years saw the growth of a new software ecosystem -Software-defined networking (SDN)- which advoca ...
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1
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TERMINÉ
Controlling Triplet Excitons in Organic Semiconductors (CONTREX)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
The urgent need to reduce carbon emissions in order to mitigate climate change requires the development of clean, renewable energy sources. Solar power offers a virtually unlimited supply of energy, providing it can be harnessed efficiently. Traditional silicon solar cells demonstrate high performance (~20%) but their required method of manufacture prohibits large area production rendering them to ...
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1
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TERMINÉ
Intelligent functional glazing with self-cleaning properties to improve the energy efficiency of the built environment (IntelGlazing)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
The latest forecast by the International Energy Agency predicts that the CO2 emissions from the built environment will reach 15.2Gt in 2050, double their 2007 levels. Buildings consume 40% of the primary energy in developed countries with heating and cooling alone accounting for 63% of the energy spent indoors. These trends are on an ascending trajectory - e.g. the average energy demand for air-co ...
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1
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TERMINÉ
Honeybee communication: animal social learning at the height of social complexity (BeeDanceGap)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,
Learning from others is fundamental to ecological success across the animal kingdom, but a key theme to emerge from recent research is that individuals respond differently to social information. Understanding this diversity is an imposing challenge, because it is hard to replicate the overwhelming complexity of free-living groups within controlled laboratory conditions. Yet here I propose that one ...
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4
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TERMINÉ
Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation applied to osteoarthritis (BAMOS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Osteoarthritis (OA) is a degenerative joint disease, typified by a loss of quality of cartilage and changes in bone at the interface of a joint, resulting in pain, stiffness and reduced mobility. BAMOS project particularly addresses the challenges in OA treatment by providing novel cost effective osteochondral scaffold technology for early intervention of OA to delay or avoid the joint replacemen ...
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4
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TERMINÉ
Art / culture / economy to democratize society. Research in placemaking for alternative narratives (trans-making)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The project trans-making aims to establish a multilateral network of research and innovation staff active in the fields of placemaking/place-based art activities as a space to create alternative narratives for social, economic and democratic renewal.It will investigate and experiment with placemaking to contribute actively to the democratization/well-being of society, educating and empowering indi ...
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15
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TERMINÉ
European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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43
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TERMINÉ
INtestinal Tissue ENgineering Solution (INTENS)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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9
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TERMINÉ
Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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19
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TERMINÉ
Boost Brittle Bones Before Birth (BOOSTB4)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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