19 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
EURopean Endeavour for Chimeric Antigen Receptor Therapies (EURE-CART)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing ...
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11
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TERMINÉ
European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry (EN_ACTI2NG)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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11
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TERMINÉ
Cardiovascular Molecular Imaging for Personalized Tailored Treatment (Neuroheart)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,
Objectives of the proposal: Heart Failure (HF) is estimated to cost the EU economy €196 billion a year. Currently, patients are treated with the highest pharmaceutical doses of antiRAS agents, which cause severe side effects and reduce the patients’ quality of life. Moreover, treatment responses are highly variable. This study aims to enable imaging-guided treatment optimization by using a radiola ...
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1
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TERMINÉ
Rational design of scaffold architecture and functionalization to induce healing and tissue regeneration (Design2Heal)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
When materials are implanted into the body they initiate an inflammatory response that is difficult to control. Consequently medical implants are tolerated by the body rather than fully integrated; the material is often sealed off from the body in a fibrotic capsule. Most recent research suggests that morphology is a decisive immunomodulatory trigger and may favor a healing-like reaction of the in ...
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1
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TERMINÉ
Mastering skills in the training Network for attention deficit hyperactivity and autism spectrum Disorders (MiND)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are frequent, chronic and highly heritable neurodevelopmental disorders. Despite their societal importance, progress in understanding disease biology has been slow and no curative treatment options are available.The pan-European training network MiND aims to educate a new generation of researchers in the field of n ...
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12
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TERMINÉ
Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe hemophilia A (HemAcure)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,
The main objective of the HemAcure project is to develop and refine the tools and technologies for a novel ex vivo prepared cell based therapy to treat the bleeding disease haemophilia A (caused by genetic deficiency in clotting factor VIII (FVIII)) that should ultimately lead to improved quality of life of the patients. The concept is a further development of our approach, established during the ...
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7
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TERMINÉ
Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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27
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TERMINÉ
Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration (HYDROZONES)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.Current cartilage implants cannot establish th ...
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18
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TERMINÉ
Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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12
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TERMINÉ
"Identification, homing and monitoring of therapeutic cells for regenerative medicine – Identify, Enrich, Accelerate" (IDEA)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
"Regenerative medicine focuses on repairing or replacing tissue or organ function lost due to damage or congenital defects using appropriate cells for therapy that have healing capacities like stem cells or progenitor cells. Although regenerative medicine has the potential for more effective therapeutic interventions major improvement in three areas are still needed for a wider establishment of su ...
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11
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TERMINÉ
Donor T Cells for Immune Control (T-CONTROL)
Date du début: 1 mai 2013, Date de fin: 31 janv. 2017,
Patients with high-risk hematological tumors can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). However, the main causes of failure of HSCT are infections, tumor relapse and over-shooting immune responses of the donor T cells to healthy cells and tissues of the patient or graft-versus host disease (GvHD). Therefore, this treatment is still associated with a high morbidity a ...
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6
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TERMINÉ
European Network for the Study of Adrenal Tumours - Structuring clinical research on adrenal cancers in adults (ENS@T-CANCER)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,
Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis. Due to this poor clinical outcome, concomitant hormone dysregulation and limited treatment options the two cancer entities severely impact on affected patients. However, the rarity of the tumors also impedes clinical studies which ar ...
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17
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TERMINÉ
European multidisciplinary ALS network identification to cure motor neuron degeneration (Euro-MOTOR)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,
Amyotrophic Lateral Sclerosis is one of the most devastating diseases in neurology affecting in Europe 50,000 individuals at any time, and causing around 10,000 deaths each year. ALS is characterized by progressive degeneration of motor neurons in brain and spinal cord leading to muscle weakness. ALS affects otherwise healthy people at any time in adulthood. The patient becomes paralyzed and dies ...
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16
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TERMINÉ
Joint European and South African Research Network in Anxiety Disorders (EUSARNAD)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
The overall aim of our proposal is to build on the strengths of an existing European network for research into causes and maintaining factors in anxiety disorders and to extend these by establishing firmer research collaboration with the University of Cape Town in South Africa.Through establishing this research exchange, we aim to share knowledge and expertise among participating centres, and ensu ...
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13
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TERMINÉ
OPtimizing TArgets and Therapeutics In high risk and refractOry Multiple Myeloma (OPTATIO)
Date du début: 1 janv. 2012, Date de fin: 31 mars 2015,
Multiple Myeloma (MM) is an incurable disease with rapidly growing prevalence and poor prognosis. Consequently, it is the goal of the OPTATIO consortium to seek out novel strategies for the development of novel diagnostic and therapeutic options. The MM pathogenesis involves not only genetic changes within the tumour cells but also the emergence of supportive conditions by the bone marrow microenv ...
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13
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TERMINÉ
Neuroscience on Barriers in Development (NEUROBID)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,
"Brain diseases are one of the most prevalent groups of diseases in Europe with estimated annual costs amounting to €386 billion (1). Data collected by the WHO suggest that brain diseases are responsible for 35% of Europe’s total disease burden (1). In the treatment of neurological disease, the blood brain barrier (BBB) still represents an obstacle for the delivery of drugs to the brain and thus a ...
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10
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TERMINÉ
Microbial-induced Angiogenesis in the Gut (MicAG)
Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,
Objective: The mammalian gut is colonized by trillions of bacteria. These gut microbes (microbiota) have coevolved with the host and developed traits that affects host physiology. Interestingly, germ-free (GF) mice exhibit arrested intestinal vascularisation if compared to littermates that were raised in a non-sterile environment (CONV-R, conventional-raised). Intestinal colonization with a normal ...
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2
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TERMINÉ
Optimizing suicide prevention programs and their implementation in Europe (OSPI-Europe)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,
Suicide is a serious public health problem in the EU calling for effective interventions. The aim of this project is to provide EU member states with an evidence based prevention concept, concrete materials and instruments for running and evaluating these interventions and recommendations for the proper implementation of the intervention. These aims will be achieved by the following objectives: &g ...
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15
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TERMINÉ
Dosimetry and Health Effects of Diagnostic Applications of Radiopharmaceuticals with particular emphasis on the use in children and adolescents (PEDDOSE.NET)
Date du début: 1 avr. 2010, Date de fin: 31 janv. 2012,
"The aim of this proposal is to provide data on dosimetry and corresponding dose related risks when administering radiopharmaceuticals for diagnostic purposes in children and adults. The composition of the consortium ensures that contacts to other bodies such as the International Commission on Radiological Protection (ICRP), the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nu ...
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