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21 projets européens trouvés

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 TERMINÉ 

MELanoma GENetics - understanding and biomarking the genetic and immunological determinants of melanoma survival (MELGEN)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survivalThe MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the impo ...
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 7

 TERMINÉ 

A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer (GANNET53)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2019,

"Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours, which are characterised by a high frequency of p53 mutations, and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. With current standard therapy the median overall survi ...
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 20

 TERMINÉ 

Radiation Innovations for Therapy and Education (RADIATE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Approximately 45-60% of all cancer patients are treated with radiotherapy. Some of these patients have a good outcome, but in other cases their illness fails to be cured. This may result from distant metastases or from regrowth of the primary tumor. This training network is built on the premise that considerable advances in understanding radiobiology will open novel routes for effective therapeuti ...
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 6

 TERMINÉ 

Research Training Network on Integrated Component Cycling in Epithelial Cell Motility (InCeM)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multipl ...
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 11

 TERMINÉ 

New Molecular-Functional Imaging Technologies and Therapeutic Strategies for Theranostic of Invasive Aspergillosis (MATHIAS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The development of novel technologies to diagnose and clinically treat invasive Aspergillus fumigatus infections is the scope of this research consortium. A. fumigatus is a ubiquitous mould whose spores are airborne and thus frequently inhaled. Humans with impaired immunity, e.g. those with haematological malignancies or bone marrow transplant recipients, are at a dramatically increased risk of se ...
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 6

 TERMINÉ 

Capture, dissemination and analysis of multiscale cell migration data for biological and clinical applications (MULTIMOT) (MULTIMOT)

Date du début: 1 août 2015, Date de fin: 31 juil. 2018,

This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migra ...
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 10

 TERMINÉ 

Consortium on Organ Preservation in Europe (COPE)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
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 16

 TERMINÉ 

Investigation of Novel biomarkers and Definition of the role of the microbiome In Graves’ Orbitopathy (INDIGO) (INDIGO)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

"Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term im ...
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 5

 TERMINÉ 

IMmune MOdulating strategies for treatment of MErkel cell Carcinoma (IMMOMEC)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

"Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer of the skin associated with the recently discovered, common Merkel cell polyomavirus (MCV). With an incidence of 0.44 per 100,000 MCC is a very rare cancer. Notably, however, although MCC is 40 times less common than malignant melanoma, MCC has a dramatically higher mortality rate than melanoma rendering MCC to ...
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 11

 TERMINÉ 

Ultra-High Field Magnetic Resonance Imaging (HiMR)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The High field Magnetic Resonance (HiMR) Initial Training Network aims to train the future leaders of academic and industrial research in the fundamental science and novel applications of ultra-high field (UHF) in vivo magnetic resonance (MR), in order to address an increasing and currently unmet demand from academia and industry for such specialists. The highly complex and multi-faceted nature of ...
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 8

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours (ASSET)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact ...
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 20

 TERMINÉ 

Robust affinity materials for applications in proteomics and diagnostics (PEPMIP)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"PEPMIP represents a joint European effort involving eleven partners aimed at the development of the next generation of dedicated separation materials, designed to recognize peptides and proteins, and the implementation of these materials in new high performance methods for peptide and protein analysis. Artificial receptors will be developed by various Molecular Imprinting techniques. This will be ...
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 11

 TERMINÉ 

EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS (ENCCA)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

"ENCCA aims to establish a durable, European Virtual Institute clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This ...
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 34

 TERMINÉ 

Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in the early clinical development (PHARMA-COG)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision bef ...
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 38

 TERMINÉ 

The European Network for Translational Research in Atrial Fibrillation (EUTRAF)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

"The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental ...
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 20

 TERMINÉ 

Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Date du début: 1 sept. 2010, Date de fin: 31 août 2015,

Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in bio ...
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 19

 TERMINÉ 

The Integrated Neurobiology of Food Intake, Addiction and Stress (NEUROFAST)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

NeuroFAST is a multidisciplinary project, involving ten teams from seven countries, to explore the neurobiology of addiction and eating behaviour and the complex socio-psychological forces that can lead to its dysregulation. These forces include dietary components (including highly palatable foods and alcohol), some of which may have addictive properties, but also cultural and social pressures, ev ...
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 13

 TERMINÉ 

Pharmaceutical Medicine Training Programme (PHARMATRAIN)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

"The proposed Pharmaceutical Medicine Training Programme provides a comprehensive solution for the complex needs of integrated drug development for all professionals involved, incl. physicians, pharmaceutical scientists,biologists, biometricians, health economists, and safety and regulatory scientists from universities, regulatory agencies, large, middle-sized and small pharmaceutical enterprises, ...
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 52

 TERMINÉ 

"Cerebellar-Cortical Control: Cells, Circuits, Computation, and Clinic" (C7)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"A functional understanding of the cerebellum, the structure of the human brain with the most neurons, requires the combined effort of scientists working from the cellular level up to the behavioural level, and it requires scientists trained to cross these levels. The C7 network brings together 9 research groups to form a European institute for the interdisciplinary study of the cerebellum. The ne ...
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 9

 TERMINÉ 

COntinuous MOnitoring of Medication Overuse Headache in Europe and Latin America: development and STAndardization of an Alert and decision support System (COMOESTAS)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

Appropriate delivery of quality healthcare requires constant monitoring of the patient during follow up, particularly in the presence of chronic diseases. This approach can be further improved if leading edge tools supporting diagnosis, as well as prediction, identification and monitoring of adverse events are available. COMOESTAS aims to develop an innovative ICT system that allows patients with ...
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 10