6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation (BIO-DrIM)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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17
Participants partenaires
TERMINÉ
Role of Epoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension (Renal functions/EETs)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2016,
Cytochrome P450 (CYP) metabolites are more frequently recognized as important regulators of cardiovascular and renal functions. CYP epoxygenases produce epoxyeicosatrienoic acids (EETs) that exhibit vasodilatory and natriuretic properties. EETs are degraded by the enzyme soluble epoxide hydrolase (sEH). Inhibition of sEH increases the level of EETs and attenuates blood pressure (BP) and end organ ...
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1
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TERMINÉ
European Training Network for Excellence in Molecular Imaging in Diabetes (BETATRAIN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Currently, 180 million people suffer from diabetes worldwide and this number is expected to double until 2030. Diabetes-related healthcare costs may rise to 40% of the total healthcare budget in high incidence countries. Despite these daunting numbers, our knowledge about the pathophysiology of T1D and T2D remains limited and many questions about the relation of the of the beta cell mass, the beta ...
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10
Participants partenaires
TERMINÉ
Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)
Date du début: 1 déc. 2010, Date de fin: 30 sept. 2014,
Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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10
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TERMINÉ
European Network for Cell Imaging and Tracking Expertise (ENCITE)
Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,
"Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and ...
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30
Participants partenaires
TERMINÉ
Personal Glucose Predictive Diabetes Advisor (DIAdvisor)
Date du début: 1 mars 2008, Date de fin: 30 juin 2012,
The DIAdvisor is a large scale integrating project (IP) aiming at development of a prediction based tool which uses past and easily available information to optimise the therapy of type I and developed type II diabetes.The DIAdvisor does not depend on specific sensor technologies and technologies like standard strip sensing, minimally-invasive continuous glucose sensors and non-invasive methods.Fo ...
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