8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Hepatic and Cardiac Toxicity Systems modelling (HECATOS)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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14
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TERMINÉ
"Health and the Understanding of Metabolism, Aging and Nutrition" (HUMAN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
"Recently intense research identified around 4,000 single nucleotide polymorphisms (SNPs) associated with human age related diseases such as metabolic disorders. Despite their highly significant association to pathology, the functional role of these genetic variants is, in most cases, yet to be elucidated. The evolutionary distance of most animal models from humans represents a major limitation fo ...
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17
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TERMINÉ
Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)
Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,
Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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17
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TERMINÉ
Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe (EXPOSOMICS)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,
This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounde ...
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15
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TERMINÉ
Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention (CVGENES-AT-TARGET)
Date du début: 1 oct. 2013, Date de fin: 31 mars 2017,
Atherosclerosis and its most disabling sequelae, coronary artery disease (CAD) and stroke, are leading causes of death in Europe. Until now, preventive and therapeutic interventions for these diseases aim at ameliorating the effects of established cardiovascular risk factors. More recently, results of genome-wide association (GWA) studies added to our perception of mechanisms leading to atheroscle ...
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13
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TERMINÉ
EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE (EPI-FEM-CARE)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,
CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or ...
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6
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TERMINÉ
"Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)" (MOD-ENP-TOX)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,
MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the to ...
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4
Participants partenaires
TERMINÉ
Data Infrastructure for Chemical Safety (diXa)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,
The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry w ...
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