5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
An in vivo imaging approach to understand pancreatic beta-cell signal-transduction (BetaImage)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
The challenge in cell physiology/pathology today is to translate in vitro findings to the living organism. We have developed a unique approach where signal-transduction can be investigated in vivo non-invasively, longitudinally at single cell resolution, using the anterior chamber of the eye as a natural body window for imaging. We will use this approach to understand how the universally important ...
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1
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TERMINÉ
Factor XII and the contact system: cross-talk between thrombosis and inflammation (F12)
Date du début: 1 août 2013, Date de fin: 31 juil. 2018,
"Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation, and the bradykinin-producing kallikrein-ki ...
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1
Participant partenaire
TERMINÉ
Synthetic Cellular Signaling Circuits (SynSignal)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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10
Participants partenaires
TERMINÉ
Identification and validation of novel pharmaceutical drug targets for cardiovascular disease (CARTARDIS)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Cardiovascular disease (CVD) is one of the major diseases in Europe and the Western world, killing over 2 million people per year in Europe alone and is the foremost cause of premature mortality and disability-adjusted life years, representing an annual economic cost of ∼€ 192 billion in direct and indirect healthcare expenses. The available therapies are insufficient to fulfill the need. The int ...
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13
Participants partenaires
TERMINÉ
"Tolerance, Pluralism and Social Cohesion. Responding to the Challenges of the 21st Century in Europe" (ACCEPT PLURALISM)
Date du début: 1 mars 2010, Date de fin: 31 mai 2013,
"In recent times, Europe has experienced increasing tensions between national majorities and ethnic or religious minorities, more particularly with marginalised Muslim communities. In some countries challenges relate more to immigrant groups while in other countries they refer to native minority claims. It is in this geopolitical context that the ACCEPT project responds to Topic 3.3.1 and notably ...
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