7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Host-microbiota interactions across the gut immune system: lessons from early onset inflammatory bowel diseases and from gnotobiotic mice (IMMUNOBIOTA)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"How the immune system controls the partnership established between mammalian hosts and the complex microbial community that colonizes their distal intestine is a fascinating topic with wide implications in physiology and pathology. In order to delineate how the two partners build and maintain mutualistic relationships, we intend to combine bench to bed-site approaches in humans and mechanistic st ...
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1
Participant partenaire
TERMINÉ
Definition and characterization of type I interferonopathies (T1-IFN)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,
"Although the concept of grouping Mendelian disorders associated with an up-regulation of type I interferon (IFN) has not been previously recognised in the medical literature, my past and current work argues that this concept has scientific validity and clinical utility. I believe that such conditions, which include Aicardi-Goutières syndrome (AGS), spondyloenchondrodysplasia, and some cases of sy ...
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2
Participants partenaires
TERMINÉ
Upscaling human insulin-producing beta cell production by efficient differentiation and expansion of endoderm progenitors (HumEn)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro. The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) gener ...
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9
Participants partenaires
TERMINÉ
Quantitative T cell Immunology (QuanTI)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,
The primary objective of this ITN is to train a new generation of European quantitative immunologists, who will be able to address challenges arising in Systems Immunology. This will be achieved with the proposed Network, Quantitative T cell Immunology (QuanTI), that will train 11 ESRs and 4 ERs, bringing together renowned experimental and theoretical scientists from private and academic instituti ...
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12
Participants partenaires
TERMINÉ
Human Genetics of Tuberculosis (GENTB)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
"Tuberculosis (TB) is not only an infectious disease, as only a small fraction of individuals infected with Mycobacterium tuberculosis (Mtb) develop disease. Over the last century, evidence has accumulated indicating that TB is also a genetic disease. However, the molecular basis of predisposition to TB remains elusive, and efforts to understand the pathogenesis of TB are of prime importance if we ...
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1
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TERMINÉ
THE HYGIENE HYPOTHESIS : REVISITING THE CONCEPT BY INTEGRATING EPIDEMIOLOGY AND MECHANISTIC STUDIES (HYGIENE)
Date du début: 1 août 2010, Date de fin: 31 juil. 2015,
The hygiene hypothesis postulating the paradoxical protective role of infections on immune-mediateddiseases including atopy (i.e. atopic dermatitis, rhinitis, asthma) and more recently autoimmune diseases hasbeen the matter of extensive investigation. The aim of the present project is to validate this hypothesisintegrating epidemiological and experimental studies.We will review in a meta-analysis ...
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2
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TERMINÉ
Development and differentiation of CD8 T lymphocytes (CD8 T CELLS)
Date du début: 1 févr. 2009, Date de fin: 31 mai 2014,
CD8 T lymphocytes have a fundamental role in ensuring the control of different types of intracellular pathogens including bacteria, parasites and most viruses. This control may fail due to several reasons. The current aggressive anti-cancer therapies (or rarely certain congenital immune deficiencies) induce CD8 depletion. After bone-marrow transplantation, long time periods are required to ensure ...
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