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12 projets européens trouvés

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 TERMINÉ 

Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial (NISCI)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Spinal cord injury is a severe and devastating neurological disorder that leaves patients with permanent paralysis of the body. No treatment is available today to regenerate interrupted nerve fibers and repair the damaged spinal cord. The incidence of spinal cord injury is about newly injured 10’000 people per year in the EU, and due to an almost normal life expectancy more than 200’000 patients a ...
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 12

 TERMINÉ 

Photoacoustic/Ultrasound Mammoscopy for evaluating screening-detected abnormalities in the breast (PAMMOTH)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

X-ray mammography is the mainstay of breast cancer screening programs. It is estimated that between 20 - 50% of abnormal screening mammograms will prove to be negative. The paradigm in diagnosis is to establish whether a lesion is benign or malignant. All the imaging techniques conventionally used today – diagnostic x-ray, ultrasonography and magnetic resonance imaging have many limitations, leadi ...
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 9

 TERMINÉ 

OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly (OPERAM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Most older adults have multiple chronic diseases (multimorbidity) and multiple medications (polypharmacy). However, multimorbid patients are often excluded from clinical trials and most guidelines address diseases in isolation. Inappropriate drug prescription and poor drug compliance are common and contribute to up to 30% of hospital admissions. OPERAM investigators developed STOPP/START criteria ...
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 9

 TERMINÉ 

Risk assessment of plaque rupture and future cardiovascular events (CVENT) by multi-spectral photoacoustic imaging (CVENT)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

Cardiovascular disease (CVD), more specifically, vulnerable plaque rupture, remains the major cause of death for people at middle age. The CVENT consortium will revolutionize screening, diagnosis and monitoring of CVD by means of a compact photoacoustic imaging (PAI) system for vulnerable plaque imaging.In the carotid arteries feeding the brain, vulnerable plaque rupture initiates cerebrovascular ...
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 10

 TERMINÉ 

A “Universal” Influenza Vaccine through Synthetic, Dendritic Cell-Targeted, Self-Replicating RNA Vaccines (UniVax)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

 TERMINÉ 

International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research (INTREALL)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study ...
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 29

 TERMINÉ 

Diagnosis and Monitoring of Inflammatory and Arthritic diseases using a COmbined approach Based on Ultrasound, optoacoustic and hyperSpectral imaging (IACOBUS)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2016,

Rheumatoid arthritis (RA) and psoriasis arthritis (PSA) are destructive polyarthritic diseases having high incidence rates worldwide of about 1,5% and 0,5% respectively. Arthritis-related joint destruction leads to disabilities which result in a loss of patient’s quality of life, often include an inability to work and significant costs for healthcare systems. The functional outcome is strongly dep ...
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 7

 TERMINÉ 

Genome-based biomarkers leading to validated molecular diagnostic tests for response prediction in breast cancer (RESPONSIFY)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,

Individualisation of cancer therapy based on standardized biomarker assays is one of the most demanding challenges in cancer medicine. In the RESPONSIFY consortium, we will integrate information on response prediction from different breast cancer types and methodologies into biomarker tests for targeted therapies in the clinical routine setting. Those tests will be developed for commercialisation ...
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 14

 TERMINÉ 

Blood-brain barrier junctions as targets for paracellular drug delivery to the brain (JUSTBRAIN)

Date du début: 1 nov. 2009, Date de fin: 30 avr. 2014,

"To maintain homeostasis of the central nervous system (CNS) the blood-brain barrier (BBB) prevents the free transcellular passage of hydrophilic molecules from the blood into the CNS. Because of this, the BBB is now recognised as the major obstacle to the treatment of most neurological disorders, as it hinders the delivery of many potentially important therapeutic and diagnostic substances to the ...
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 8

 TERMINÉ 

Nano Health-Environment Commented Database (NHECD)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

We propose to use our recent advanced research results and build a novel and useful automatic database on the impact of nano-particles on health and environment, which will be hosted and maintained by a expert software company based in Europe. The strength and innovation is double folded: primarily in automatic extraction and understanding from free text, which is in particular suited to create a ...
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 4

 TERMINÉ 

MULTIMODAL SKIN INSPECTION WITH HYBRID ACOUSTIC & OPTICAL SPECTROSCOPIC IMAGING (SKINSPECTION)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,

"The incidence of skin cancer in Europe, US, and Australia is rising rapidly. One in five will develop some form of skin cancer during the lifetime. A person has a 1:33 chance to develop melanoma, the most aggressive skin cancer. Melanoma is the second most common cancer in women aged 20-29, and the sixth most common cancer in men and women. In 2007, more than 1 million new cases will be diagnosed ...
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 6

 TERMINÉ 

Identification and validation of new breast cancer biomarkers based on integrated metabolomics (METAcancer)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,

Breast cancer is the most common cancer in women. It is therefore in the focus of approaches for the identification of predictive molecular biomarkers. In contrast to transcriptomics, the changes in metabolite levels that are associated with tumor development and progression have not been investigated to a great extent, so far. Metabolomics is defined as the study of all metabolites in a cell, ti ...
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 8