Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Structured nonlinear Metamaterials for efficient generation and Active functional control of Radiation of THz light (SMART)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The terahertz optical regime, covering the long wavelength end of the optical spectrum, has been for many years the least explored spectral regime. Recent interest in this regime has led to important emerging applications spanning many disciplines including medical, biological, materials sciences, communications, security, and basic sciences. However, advances in these emerging applications are he ...
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1
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TERMINÉ
Novel Mechanism of Behavioural Change (ChangeBehavNeuro)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Understanding how values of different options that lead to choice are represented in the brain is a basic scientific question with far reaching implications. I recently showed that by the mere-association of a cue and a button press we could influence preferences of snack food items up to two months following a single training session lasting less than an hour. This novel behavioural change manipu ...
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1
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TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
Selective glycoimmuno-targeting for cancer therapy (SweetAim)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Immunotherapy recently became an important alternative to conventional treatment regimes, yet cancer remains a universal leading cause of death. Thus, novel cancer theranostic approaches are still much desired. Although altered cell surface glycosylation is one of the hallmarks of cancer, targeting this ‘sweet aim’ for cancer therapy has been elusive, largely due to carbohydrates poor immunogenici ...
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1
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TERMINÉ
Spiking network mechanisms underlying short term memory (HIRESMEMMANIP)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
Short term memory (STM) is impaired at old age and a host of neuropsychiatric disorders, and has been the focus of a multitude of psychological and theoretical studies. However, the underlying neuronal circuit mechanisms remain elusive, mainly due to the lack of experimental tools: we suggest that rapid manipulations at the neuronal level are required for deciphering underlying mechanisms. We have ...
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1
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TERMINÉ
Zero sets of random functions (RandomZeroSets)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
"The proposed research is focused on zero sets of random functions. This is a rapidly growing area that lies at the crossroads of analysis, probability theory and mathematical physics. Various instances of zero sets of random functions have been used to model different phenomena in quantum chaos, complex analysis, real algebraic geometry, and theory of random point processes.The proposal consists ...
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1
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TERMINÉ
Resolving the Nuts and Bolts of Gene Body Methylation (GeneBodyMethylation)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
DNA methylation, the covalent binding of a methyl group (CH3) to cytosine base, regulates the genome activity and plays a fundamental developmental role in eukaryotes. Its epigenetic characteristics of regulating transcription without changing the genetic code together with the ability to be transmitted through DNA replication allow organisms to memorize cellular events for many generations. DNA m ...
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1
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TERMINÉ
Hybrid Optical Interferometry for Quantitative Cancer Cell Diagnosis (OptiQ-CanDo)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this ...
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1
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TERMINÉ
Bayesian Networks and Non-Rational Expectations (BAYNET)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
"This project will develop a new framework for modeling economic agents having "boundedly rational expectations" (BRE). It is based on the concept of Bayesian networks (more generally, graphical models), borrowed from statistics and AI. In the framework's basic version, an agent is characterized by a directed acyclic graph (DAG) over the set of all relevant random variables. The DAG is the agent's ...
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2
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TERMINÉ
Bio-Inspired Self-Assembled Supramolecular Organic Nanostructures (BISON)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
Peptide building blocks serve as very attractive bio-inspired elements in nanotechnology owing to their controlled self-assembly, inherent biocompatibility, chemical versatility, biological recognition abilities and facile synthesis. We have demonstrated the ability of remarkably simple aromatic peptides to form well-ordered nanostructures of exceptional physical properties. By taking inspiration ...
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1
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TERMINÉ
Multi-scale analysis of the interplay between cell morphology and cell-cell signaling (MorphoNotch)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
Signaling, genetic regulatory circuits, and tissue morphology are inherently coupled to each other during embryonic development. Although changes in cellular and tissue morphology are commonly treated as a downstream consequence of cell fate decision processes, there are multiple examples where morphological changes occur concurrently with the differentiation processes. This suggests that a feedba ...
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1
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TERMINÉ
The new flow of news : how social network sites transform news organization and citizens political behavior (SNSNEWS)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
News industry is undergoing a major transition: Traditional news consumption is on the decline, while citizens increasingly turn their attention to social network sites (SNSs). To accommodate this trend, news industry has been incorporating SNSs into its platforms, changing news into a social product. The project will explore this process and reveal its implications for news production and audienc ...
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1
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TERMINÉ
Going Beyond the WIMP: From Theory to Detection of Light Dark Matter (LDMThExp)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
The identity of dark matter (DM) is still unknown. For more than three decades, significant theoretical and experimental efforts have been directed towards the search for a Weakly Interacting Massive Particle (WIMP), often overlooking other possibilities. The lack of an unambiguous positive signal, at indirect- and direct-detection experiments and at the LHC, stresses the need to expand on other t ...
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1
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TERMINÉ
Foraging Decision Making in the Real World – revealed from a bat’s point of view by on-board miniature sensors (GPS-Bat)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
How animals make decisions in the wild is an open key-question in biology. Our lack of knowledge results from a technological gap – the difficulty to track animals over long periods while monitoring their behaviour; and from a conceptual gap – how to identify animals’ decision-points outdoors? We suggest applying our innovative on-board miniature sensors, to study decision making in the wild. We ...
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1
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TERMINÉ
A direct, multi-faceted approach to investigate plant hormones spatial regulation: the case of gibberellins (GAtransport)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,
Plants evolved a unique molecular mechanism that spatially regulate auxin, forming finely tuned gradients and local maxima of auxin that inform and direct developmental patterning and adaptive growth processes. Recent findings call into question the uniqueness of polar auxin transport in the sense that more plant hormones seem to be actively transported. Although still lacking many mechanistic det ...
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1
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TERMINÉ
Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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33
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TERMINÉ
Do behaving animals extract information from precise spike timing? – The use of temporal codes (Temporal Coding)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Neural temporal codes have come to dominate our way of thinking on how information is coded in the brain. When precise spike timing is found to carry information, the neural code is defined as a temporal code. In spite of the importance of temporal codes, whether behaving animals actually use this type of coding is still an unresolved question. To date studying temporal codes was technically impos ...
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1
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TERMINÉ
Localization and Ordering Phenomena in Statistical Physics, Probability Theory and Combinatorics (LocalOrder)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Mathematical statistical physics has seen spectacular progress in recent years. Existing problems which were previously unattainable were solved, opening a way to approach some of the classical open questions in the field. The proposed research focuses on phenomena of localization and long-range order in physical systems of large size, identifying several fundamental questions lying at the interfa ...
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1
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TERMINÉ
Random Geometry (RANDGEOM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The objective of this proposal is an investigation of the geometric structure of random spaces that arise in critical models of statistical physics. The proposal is motivated by inspiring yet non-rigorous predictions from the physics community and the models studied are some of the most popular models in contemporary probability theory such as percolation, random planar maps and random walks.One s ...
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1
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TERMINÉ
Harnessing Targeted Nanotheranostics to Reprogram Activated Leukocytes in Inflammatory Bowel Disease (LeukoTheranostics)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
"Inflammatory bowel diseases (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn’s disease (CD) and Ulcerative Colitis (UC) that can impact both the large and small bowel. IBD affects approximately 3.7 million Europeans and its peak onset is in persons of 15 to 30 years of age. IBD imposes a significant burden on Europe with over €3B in annual health ...
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2
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TERMINÉ
Fibre Nervous Sensing Systems (FINESSE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
The unprecedented properties of optical fibres make them ideal to be implemented as 'artificial nervous systems', enabling any tool or structure to become a sensitive and smart object. Conventional optical fibres are small, low-cost and can be seamlessly integrated in materials, in engineering structures and in the environment. By exploiting the most advanced light-matter interactions, these tiny ...
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10
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TERMINÉ
Synthesis Technologies for Reactive Systems Software Engineers (SYNTECH)
Date du début: 1 avr. 2015, Date de fin: 30 sept. 2020,
The design and development of open reactive systems, which compute by reacting to ongoing stimuli from their environment, and include, for example, mobile applications running on smart phone devices, web-based applications, industrial robotic systems, embedded software running on chips inside cars and aircraft, etc., is a complex and challenging task. Despite advancement from low-level assembly la ...
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1
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TERMINÉ
Cost effective FCL using advanced superconducting tapes for future HVDC grids (FASTGRID)
Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,
Sustainability of energy systems goes through high penetration of renewable energy with huge volumes of electricity to transmit over long distances. The most advanced solution is the HVDC Supergrid. But fault currents remain an issue even if DC circuit breakers have emerged. These are not satisfying, whereas Superconducting Fault Current Limiters (SCFCLs) using REBCO tapes bring an attractive solu ...
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14
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TERMINÉ
A Genetic View of Influenza Infection (GV-FLU)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Inherited variation in the quantity and functionality of immune cells plays a key role in determining phenotypic diversity between individuals. Surprisingly little is known, however, about the specific contribution of immune cell subsets to variation in phenotypes such as susceptibility to infectious diseases and the underlying genetic variation. In many complex diseases, we currently have a poor ...
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1
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TERMINÉ
Discovery of breast cancer aggressiveness markers using topo-proteomics mapping (PROTEOMICAN)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
"In the proposed research we will explore the functional proteomic diversity of histologically-defined regions within human breast tumors, aiming to identify novel protein biomarkers of tumor aggressiveness. Once identified, these proteins will serve as potent diagnostic markers and therapeutic targets. Towards this aim we will perform genome-scale proteomic profiling on tumor regions displaying d ...
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1
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TERMINÉ
Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis (MetCAF)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Mortality from breast cancer is almost exclusively a result of tumor metastasis. Since advanced metastatic cancers are usually fatal, understanding the biology of tumor metastasis is the most significant challenge in cancer research today. It has become clear that the microenvironment of tumors is crucial in supporting tumor growth. Nevertheless, the role of the metastatic microenvironment in faci ...
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1
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TERMINÉ
Next-Generation Cardiac Tissue Engineering: Smart Self-Regulating Patches (SmartCardiacPatch)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Ischemic heart disease is a major cause of death in the Western world. There is no sustainable regenerative therapy available at the moment, with cardiac transplantation being the only therapy. However, tissue engineering is envisioned as a true regenerative therapeutic alternative. Despite the incremental improvements no technology is currently available that can provide on-line monitoring and re ...
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1
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TERMINÉ
Quantifying the structure-function of the neurovascular interface: from micro-circuits to large-scale functional organization (MultiScaleNeurovasc)
Date du début: 1 juin 2015, Date de fin: 31 mai 2020,
Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions. In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia. This coupling between neuronal and vascular activtuy underpins the ...
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1
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TERMINÉ
Spectral theory of random operators (SPECTRUM)
Date du début: 1 juin 2015, Date de fin: 31 mai 2020,
The theme of this proposal is the study of random operators associated with some geometric structure, and the influence of the geometry on the spectral properties of the operator. Such operators appear in problems from theoretical physics, and lead to new and interesting mathematical structures.One circle of questions is related to random operators, which describe the motion of a quantum particle ...
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1
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TERMINÉ
Cloud-MicroPhysics-Turbulence-Telemetry: An inter-multidisciplinary training network for enhancing the understanding and modeling of atmospheric clouds (COMPLETE)
Date du début: 1 juin 2016, Date de fin: 31 mai 2020,
Clouds are the largest source of uncertainty in weather prediction, climate science, and remain a weak link in modeling atmospheric circulation. This is rooted in the fact that clouds depend on the physical and chemical processes over a huge range of scales, from the collisions of micron-sized droplets and particles to the airflow dynamics on the scales of thousands of meters. Since ambiguities re ...
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9
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TERMINÉ
Cryptography with Low Complexity (CLC)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,
The efficiency of cryptographic constructions is a fundamental question. Theoretically, it is important to understand how much computational resources are needed to guarantee strong notions of security. Practically, highly efficient schemes are always desirable for real-world applications. More generally, the possibility of cryptography with low complexity has wide applications for problems in com ...
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1
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TERMINÉ
The Sign Hub: preserving, researching and fostering the linguistic, historical and cultural heritage of European Deaf signing communities with an integral resource (SIGN-HUB)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,
SIGN-HUB aims to provide the first comprehensive response to the societal and scientific challenge resulting from generalized neglect of the cultural and linguistic identity of signing Deaf communities in Europe. It will provide an innovative and inclusive resource hub for the linguistic, historical and cultural documentation of the Deaf communities' heritage and for sign language assessment in cl ...
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13
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TERMINÉ
Quasi-Randomness in Extremal Combinatorics (EXTPRO)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
Combinatorics is an extremely fast growing mathematical discipline. While it started as a collection of isolated problems thatwere tackled using ad-hoc arguments it has since grown into a mature discipline which both incorporated into it deep tools from other mathematical areas, and has also found applications in other mathematical areas such as Additive Number Theory, Theoretical Computer Science ...
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1
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TERMINÉ
Symplectic Measurements and Hamiltonian Dynamics (SYMPLECTIC)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
Symplectic geometry combines a broad spectrum of interrelated disciplines lying in the mainstream of modern mathematics. The past two decades have given rise to several exciting developments in this field, which introduced new mathematical tools and opened challenging new questions. Nowadays symplectic geometry reaches out to an amazingly wide range of areas, such as differential and algebraic geo ...
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1
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TERMINÉ
Foundations of Cryptographic Hardness (FOC)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
A fundamental research challenge in modern cryptography is understanding the necessary hardness assumptions required to build different cryptographic primitives. Attempts to answer this question have gained tremendous success in the last 20-30 years. Most notably, it was shown that many highly complicated primitives can be based on the mere existence of one-way functions (i.e., easy to compute and ...
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1
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TERMINÉ
Mid Infra-Red near-field control by Adiabatic frequency Generation Enabling 20fs/15nm resolution (MIRAGE 20-15)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
The goal of this proposal is to allow observing and controlling ultrafast phenomena in a spatio-temporal window of 20fs-15nm at mid-IR by merging the extreme temporal resolution of the recently developed single-cycle mid-IR pulses with the spatial resolution of near field scattering optical microscope (aSNOM). The mid-infrared wavelength regime is of particular importance to materials science, che ...
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1
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TERMINÉ
An Information Theory of Simple Interaction (InfoInt)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
Motivated by our recent progress in feedback information theory and its deep relations to stochastic dynamical systems, and inspired by natural phenomena such as bio-molecular interactions and human conversation, this research will explore the fundamental limits of information transfer via simple interaction. In the standard information theoretic framework, the problem of reliable communications i ...
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1
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TERMINÉ
Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)
Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,
Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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23
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TERMINÉ
GlucoCEST Imaging of Neoplastic Tumours (GLINT)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Cancer is one of the most devastating diseases the world is currently facing, accounting for 7.6 million deaths in 2008 (WHO). Cancer is usually detected through advanced medical imaging. Early detection is very important as it increases the chances of survival and the potential for full recovery. Further, The high level of sophistication in treating cancer has led to a new unsolved problem, the d ...
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8
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TERMINÉ
Up to University - Bridging the gap between schools and universities through informal education (Up2U)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,
The key objective of our project is to bridge the gap between secondary schools and higher education and research by better integrating formal and informal learning scenarios and adapting both the technology and the methodology that students will most likely be facing in universities.We are focusing on the context of secondary schools, often referred to as high schools, which provide secondary edu ...
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