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TERMINÉ
AnTBiotic – progressing TB drug candidates to clinical proof of concept (anTBiotic)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Tuberculosis (TB) today rivals HIV/AIDS as the leading cause of death from infectious diseases. The number of TB patients has never been higher and the growing proportion of drug-resistant TB is threatening control strategies both in the developing and developed world, Eastern Europe being a particularly worrying point in case. The anTBiotic consortium aims to fuel the long-term TB clinical pipeli ...
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TERMINÉ
Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,
"Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade.Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole ...
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