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Background: The DNA damage response (DDR) is a specialised stress response fundamental to maintaining genome integrity and suppressing tumour formation. Traditional molecular and cellular biology, combined with genetics and biochemistry, have led to an understanding of the architecture of the DDR in a variety of model organisms and in human cells. These studies have employed populations of cells/ ...

The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage r ...