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Plus de 40 projets européens trouvés

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 TERMINÉ 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 TERMINÉ 

Frontiers in Quantum Materials Control (Q-MAC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2019,

The overarching goal of the present proposal is to exploit materials design, coherent optical methods and multiple theoretical approaches to deterministically control ordered states of strongly correlated electron materials, also referred to as “quantum” or “complex” materials. The underlying ideas can be applied to vast number of problems in materials physics, but the stated goal is that of optim ...
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 4

 TERMINÉ 

The Developing Human Connectome Project (dHCP)

Date du début: 1 sept. 2013, Date de fin: 31 août 2019,

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectiv ...
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 4

 TERMINÉ 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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 27

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

Targeted Action for Curing Trauma Induced Coagulopathy (TACTIC)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

"Trauma remains one of the world’s biggest contributors to the global burden of disease. Predominantly affecting young adults and children, 800,000 European injury related deaths were recorded in 2002. Outcomes for critically injured trauma patients remain poor with severe bleeding, brain injury and tissue damage being associated with high mortality and disability. Nearly half of all trauma fatali ...
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 9

 TERMINÉ 

Cognitive Biases - Windows into the Mechanisms underlying Emotional Vulnerability and Resilience (CogBIAS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"Every person responds to life's difficulties in different ways. But why do some 'suffer the slings and arrows of outragerous fortune' and other 'take arms against a sea of trouble'. There are those who are vulnerable and fragile, falling prey to anxiety, depression and a range of compulsions that, left unattended, can easily turn into addicitons. Then there are the those who irrespective of what ...
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 1

 TERMINÉ 

Targeting and exploiting B cell functions for treatment in cardiovascular disease (Athero-B-Cell)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Cardiovascular disease (CVD) mortality and morbidity is predicted to increase in Europe and worldwide in the next decades due to aging and the rise of diabetes and obesity. The link between metabolic and inflammatory disease is getting stronger, raising hopes for novel therapeutic targets to be exploited clinically. Clinical evidence generated by the Academic partners of the Athero-B-Cell Consorti ...
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 11

 TERMINÉ 

Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics. The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct cer ...
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 12

 TERMINÉ 

Preventing Abuse of Children in the Context of AIDS in sub-Saharan Africa (PACCASA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

"To date, 12 million children have been orphaned by AIDS, and 70 million more live with AIDS-affected caregivers within sub-Saharan Africa. Our programme of research has demonstrated heightened levels of physical, sexual and emotional abuse amongst children in AIDS-affected families. Despite increasing calls for intervention studies addressing child abuse in the developing world (UN 2008; WHO 2010 ...
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 1

 TERMINÉ 

Improving Prostate Cancer Outcome with Vectored Vaccines (IMPROVE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

A successful vaccine against cancer is most likely to work through the induction of potent CD8+ T cells that can successfully kill tumour cells. But achieving this has proved difficult and only low level responses are induced by current vaccine approaches. Nonetheless, two therapeutic immunisation strategies have shown partial success in targeting prostate cancer, and one recently reached licensur ...
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 5

 TERMINÉ 

Assessment of the impact of drivers of change on Europe's food and nutrition security (TRANSMANGO)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

TRANSMANGO aims to obtain a comprehensive picture of the effects of the global drivers of change (climate, economic concentration and market structure, financial power, resource competition, marginalization, property rules, geo-political shifts, consumer preferences, consumption patterns and nutritional transition) on European and global food demand and on raw material production (and, consequent ...
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 13

 TERMINÉ 

industry-Academia Research on Three-dimensional Image Sensing for Transportation (IARTIST)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

An industry academic partnership project to enhance research and knowledge transfer in the field of three dimensional image processing for transportation industry.
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 4

 TERMINÉ 

Economic Modeling for Climate-Energy Policy (ECOCEP)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"Climate change is one of the most challenging and important problems facing European and world society. Our project concentrates on several key aspects of climate change economics, including the valuation of climate change impacts, the main determinants of key drivers of climate change, the economic impact of climate change mitigation policies and the examination of climate change related risks, ...
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 4

 TERMINÉ 

Indo European Collaboration on Moduli Spaces (MODULI)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"This proposal is concerned with a joint Indo-European presearch programme on the field of moduli spaces. Moduli spaces are basic and central objects that emerge in the most natural classification problems in geometry. Their importance has been emphasized over the years due to the relation of these spaces with areas of mathematics so diverse as algebraic geometry, differential geometry, topology, ...
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 4

 TERMINÉ 

Freezing Colloids (FREECO)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

The freezing of colloids is an amazingly common phenomenon encountered in many natural and engineering processes such as the freezing of soils, food engineering or cryobiology. It can also be used as a bioinspired, versatile and environmentally-friendly processing route for bioinspired porous materials and composites exhibiting breakthroughs in functional properties. Yet, it is still a puzzling ph ...
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 2

 TERMINÉ 

Impact of Biogenic versus Anthropogenic emissions on Clouds and Climate: towards a Holistic UnderStanding (BACCHUS)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

Clouds are a very important, yet not well understood feedback factor in climate change and they contribute to the effective radiative forcing (ERF) from aerosol-cloud interactions (ACI). The uncertainty in ERFaci is larger than for any other forcing agent. Also, feedbacks between the terrestrial and marine biosphere and the atmosphere involving ACI are thought to play an important role in regulati ...
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 22

 TERMINÉ 

Cold Molecular Ions at the Quantum Limit (COMIQ)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"COMIQ (COld Molecular Ions at the Quantum limit)will investigate how cooling, trapping, and control techniques applied molecular ion can expand the realm of quantum technology, enhance precision meaurements on molecular systems and lead to chemistry at the ultracold quantum limit."
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 10

 TERMINÉ 

European Research Infrastructures for Poverty Related Diseases (EURIPRED)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

HIV/AIDS, Tuberculosis (TB) and Malaria alone account for more than six million deaths worldwide every year. Despite substantial efforts made in recent years, Poverty Related Diseases are still spreading. New therapeutic interventions are therefore urgently required to combat Poverty Related Diseases. The existence of a well-developed HIV/TB/Malaria infrastructure presents a prime opportunity to a ...
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 18

 TERMINÉ 

PHYSICAL ACTIVITY THROUGH SUSTAINABLE TRANSPORT APPROACHES (PASTA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

This project focuses on the systematic promotion and facilitation of active mobility (AM) (i.e. walking and cycling including the combination with public transport use) as an innovative approach to integrate physical activity (PA) into individuals’ everyday lives. In contrast to sports or exercise, AM requires less time and motivation, since AM provides both convenience as a mode of transport, and ...
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 18

 TERMINÉ 

Individualised Diagnostics and Rehabilitation of Attention (INDIREA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"We propose a training network based around a linked set of research projects which attempt to improve the diagnosis and rehabilitation of neuropsychological disorders of attention, with each project linked to an external industrial partner in order to commercialise emerging diagnostic and rehabilitation procedures. New diagnostic procedures will link clinical measures of attentional disorders to ...
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 8

 TERMINÉ 

Power and Region in a Multipolar Order (PRIMO)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"PRIMO (Power and Regions in a Multipolar World) starts from the premise that the importance of non-western regions and certain of their leading states – notably Brazil, Russia, India, China and South Africa, the so-called BRICS states – for international politics and the world economy is rapidly growing. However, the nature of these processes, the consequences for global governance, and the mater ...
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 11

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

ADvanced Electric Powertrain Technology (ADEPT)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The goal of the ADEPT program is to produce a virtual development environment for E-propulsion systems and to train and establish a multi-disciplinary research network. The ADEPT program will raise the profile and to improve career perspectives for 12 ESRs, and 2 ERs, offering a high-quality structured consortium providing personalized training opportunities in E-propulsion systems and in compleme ...
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 12

 TERMINÉ 

Macroeconomics and Financial History (MACROHIST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

"The current macroeconomic and financial crisis has given rise to a vigorous debate about the state of macroeconomics and macroeconomic training. Among the voices arguing most strongly for a change in the way that young macroeconomists are trained are those coming from employers in the private and public sector. Strikingly, many employers are also arguing that a knowledge of economic history might ...
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 7

 TERMINÉ 

Improving the Physics in Ice Sheet Models (ImPISM)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The aim of this project is to generate new understanding of glacier and ice-sheet dynamics. Specifically, it will improve theoretical models of the physical processes occurring at the base of the ice, and develop the means to integrate these into large-scale simulations used to forecast ice melting and sea level rise. This will provide a vital step forward in the capabilities of these models to ...
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 1

 TERMINÉ 

Digital Scholarly Editions Initial Training Network (DiXiT)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The Digital Scholarly Editions Initial Training Network (DiXiT) is concerned with one of the most dynamic and pioneering research areas at the intersection of the humanities and computer sciences focused on digital scholarly editions. While the digital turn has challenged the theoretical understanding of and the methodological approach to the core research activity in most of the humanities, there ...
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 10

 TERMINÉ 

Photonic Integrated Compound Quantum Encoding (PICQUE)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

"Quantum information was born from the merging of information science and quantum physics. Its main objective consists of harnessing the quantum nature of information and learning how to process it by using physical systems operating according quantum mechanics laws. Being supported by numerous proofs-of-principle, the field is now ready to proceed to move to the next level of applications, where ...
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 10

 TERMINÉ 

Nano -structural and -dynamic events in the T-cell activation (nanodynaTCELLvation)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The organization of the T-cell in its resting and activated state, specifically of plasma-membrane molecules involved in the triggering of the T-cell, is a long-standing and contentious research topic in molecular immunology. Understanding the molecular mechanisms involved at the nanoscale, i.e. at spatial scales below the resolution limit of conventional optical microscopy (< 200 nm) will find an ...
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 2

 TERMINÉ 

Low Emissions Core-Engine Technologies (LEMCOTEC)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,

The main objective of the LEMCOTEC project will be the improvement of core-engine thermal efficiency by increasing the overall pressure ratio (OPR) to up to 70 leading to a further reduction of CO2. Since NOx increases with OPR, combustion technologies have to be further developed, at the same time, to at least compensate for this effect. The project will attain and exceed the ACARE targets for 20 ...
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 39

 TERMINÉ 

Advanced materials and devices for hybrid spin coherent technologies (ASCENT)

Date du début: 1 déc. 2011, Date de fin: 30 juin 2017,

The property of spin has been harnessed in an array of revolutionary technologies, from nuclear spins in magnetic resonance imaging to spintronics in magnetic recording media. Nature at its deepest level is quantum mechanical and spins are capable of demonstrating superposition and entanglement, yet such coherent properties have not yet been fully exploited. The exquisite control over materials fa ...
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 2

 TERMINÉ 

The genetic basis of meningococcal and other life threatening bacterial infections of childhood (EUCLIDS)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2017,

Bacterial infection is the major cause of disability and death in children worldwide. We will use meningococcal disease (MD) as a model to understand genetic factors underlying susceptibility and severity of childhood bacterial infection which will then be applied to other childhood infections. We have established cohorts of patients with MD in Central and Southern Europe (CE,SE), UK and Africa as ...
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 16

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 

Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2017,

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most rele ...
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 27

 TERMINÉ 

Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention (CVGENES-AT-TARGET)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2017,

Atherosclerosis and its most disabling sequelae, coronary artery disease (CAD) and stroke, are leading causes of death in Europe. Until now, preventive and therapeutic interventions for these diseases aim at ameliorating the effects of established cardiovascular risk factors. More recently, results of genome-wide association (GWA) studies added to our perception of mechanisms leading to atheroscle ...
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 13

 TERMINÉ 

International Research Consortium on Dengue Risk Assessment, Management, and Surveillance (IDAMS)

Date du début: 1 sept. 2011, Date de fin: 28 févr. 2017,

The overall concept of this research project is to assemble a consortium of international experts working together to develop new and innovative tools to be applied to the control of dengue in a global context. The core of the application focuses on parallel strategies aimed at:• improving diagnosis and clinical management of dengue through two linked work packages designed a) to identify readily ...
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 18

 TERMINÉ 

EUropean CLimate and weather Events: Interpretation and Attribution (EUCLEIA)

Date du début: 13 nov. 2013, Date de fin: 1 janv. 2017,

Climate change is expected to impact extreme weather in Europe. There is therefore a clear need to adapt effectively to climate change, particularly in Europe, where recent heatwaves, floods and droughts have demonstrated the vulnerability of European citizens to extreme weather. However, scientifically robust information about the extent to which recent extreme weather can be linked to climate va ...
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 11

 TERMINÉ 

3to4: Converting C3 to C4 photosynthesis for sustainable agriculture (3TO4)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

Most plants use the C3 pathway of photosynthesis that is compromised by gross inefficiencies in CO2 fixation. However, some plants use a super-charged photosynthetic mechanism called C4 photosynthesis. The C4 pathway is used by the most productive vegetation and crops on Earth. In addition to faster photosynthesis, C4 plants demand less water and less nitrogen. Overall, our aim is to introduce the ...
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 20

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

European Clinical trials in Rare Sarcomas within an integrated translational trial network (EUROSARC)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical ...
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 22