9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,
Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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12
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TERMINÉ
Elucidating Pathways of Steatohepatitis (EPoS)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,
Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibr ...
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13
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TERMINÉ
Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
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21
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TERMINÉ
Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders (METSY)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
"The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychot ...
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13
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TERMINÉ
Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines ...
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10
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TERMINÉ
Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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12
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TERMINÉ
Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes (BetaBat)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose me ...
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12
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TERMINÉ
Developing an efficient e-infrastructure, standards and data-flow for metabolomics and its interface to biomedical and life science e-infrastructures in Europe and world-wide (COSMOS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2015,
Metabolomics is an important phenotyping technique for molecular biology and medicine. It assesses the molecular state of an organism or collections of organisms through the comprehensive quantitative and qualitative analysis of all small molecules in cells, tissues, and body fluids. Metabolic processes are at the core of physiology. Consequently, metabolomics is ideally suited as a medical tool t ...
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16
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TERMINÉ
Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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