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Peptide ligands with restricted mobility through a Suzuki reaction: design, synthesis and evaluation (suzuki peptides)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,
The aim of this research proposal is the application of the Suzuki-Miyaura reaction to the synthesis of peptidic libraries with restricted mobility. Specifically, we envision the synthesis of a family of cyclic peptides that will contain a biaryl bond, to further restrain their conformation. This biaryl bond will be obtained through a Suzuki-Miyaura set of reactions between two aromatic amino acid ...
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