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13 projets européens trouvés

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 TERMINÉ 

Noncoding and Translational Modulation of Gene Expression and Epigenetic Changes (TRANSLATE)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"Gene expression studies rely on high throughput techniques, which do not take in account conceptual limits. I will overcome this situation by exploiting two biological facts. First, RNAs that are important in tissue function are a subset of the global mass, but are always associated with the ribosomal machinery and as such should be identified. Second, gene expression is the outcome of dynamic fl ...
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 3

 TERMINÉ 

The physiology and genetics of fruit formation: from genes to networks (FRUIT LOOK)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"The fruit is the result of the development of the ovary and it is a major evolutionary acquisition of flowering plants. Fruits likely evolved to protect the developing seeds and to ensure seed dispersal adopting an incredible array of morphologies and inventing many types of mechanisms for seed dispersal. Dry dehiscent fruits mechanically disperse the seeds, while fleshy fruits develop tasty tiss ...
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 3

 TERMINÉ 

Role of the transcription factor Nfix in muscle regeneration and muscular dystrophies (RegeneratioNfix)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

I will study the role of the transcription factor Nfix, in post-natal skeletal muscle growth and regeneration, and in the pathogenesis of muscular dystrophies. I have recently demonstrated the role of the transcription factor Nuclear Factor IX, Nfix, in driving the transcriptional switch from embryonic to fetal myogenesis, characterized by a switch from slow to fast twitching and more mature fibe ...
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 1

 TERMINÉ 

Floral Integrating Networks at the Shoot Apical Meristem of Rice (FLARE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

Discriminating differences in day length is critical for many organisms to synchronize reproduction with the most favourable season of the year. Plants have evolved sophisticated time-keeping mechanisms that largely work in leaves, to measure the duration of the day. Upon perception of favourable day lengths, a leaf-borne signal moves to the shoot apical meristem to induce flower formation. Rice i ...
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 1

 TERMINÉ 

AnThocyanin and polyphenol bioactives for Health Enhancement through Nutritional Advancement (ATHENA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2015,

Anthocyanins are health promoting dietary polyphenols that protect against cardiovascular disease, caner and obesity in preclinical studies with animals. The ATHENA project will address how good dietary anthocyanins are in protecting against chronic disease, by addressing the following questions: • Benefits and risks: What is the dose response to anthocyanin phytonutrients? Are anthocyanins from d ...
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 14

 TERMINÉ 

Yeast biodiversity as a source of innovations in food and health (CORNUCOPIA)

Date du début: 1 févr. 2011, Date de fin: 30 avr. 2015,

"Cornucopia will train a new generation of young scientists focusing on less studied yeasts with interesting traits, which could be applied in the food and health sectors. Yeasts are a divergent group of fungi that predominantly exist as unicellular organisms. The baker's yeast Saccharomyces cerevisiae is by far the best known because of its role in producing beverages, baking and recombinant drug ...
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 10

 TERMINÉ 

Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

 TERMINÉ 

Evolutionary Conservation of Regulatory Network Controlling Flower Development (EVOCODE)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

This research exchange programme focuses on plant reproduction. The world population depends for its nutrition on agricultural crop products, mainly as seeds and fruits. Improvements of crop plants to achieve better yields under suboptimal growth conditions will be essential to keep up with the increase in world population and to reduce the impact of high yield farming on the environment. Most agr ...
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 3

 TERMINÉ 

MADS box transcription factors: interactions between metabolic pathways and seed development (METMADS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

"Seed development is a complex process that requires the coordination in growth and development of the integuments, the embryo and the endosperm. The roles of integuments in seed development as well as the cross talk between the maternal tissues (the integuments) and the fertilization products (the embryo and the endosperm) represent intriguing arguments since many years.MADS-box genes have been t ...
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 1

 TERMINÉ 

INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe (INHERITANCE)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,

"Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The ...
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 11

 TERMINÉ 

Novel Approaches to Bacterial Target Identification, Validation and Inhibition (NABATIVI)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

Despite the advent of the antibiotic era, infectious diseases retain their pre-eminent position as major worldwide causes of morbidity and mortality. This problem has been worsen by the emergence of multi-antibiotic resistant bacteria and the failure of Pharmaceutical company drug discovery programmes to design antibiotics with truly novel modes of action. NABATIVI has put together a unique consor ...
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 10

 TERMINÉ 

A Nit in the Lab-2 (NITLAB-2)

Date du début: 1 juin 2009, Date de fin: 31 déc. 2009,

"The main aim of the present proposal is to bring researchers involved in different researcher’s branches closer to the large public, without any distinction of age, gender, level of scientific training or social category. In general, the proposed action intends to oppose the stereotypes about researchers and their profession, giving the opportunity to perceive them as “ordinary people”. In Italy ...
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 1

 TERMINÉ 

A night in the lab (NITLAB)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2008,

The main aim of the present proposal is to bring researchers involved in biomedical research closer to the large public, without any distinction of age, gender, level of scientific training or social category. The proposed action intends to oppose the stereotypes about researchers and their profession, giving the opportunity to perceive them as “ordinary people”. On the other hand, in the last yea ...
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 1