16 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Individual Robustness in Development and Cancer (IR-DC)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
Biological systems are robust to perturbations, with many genetic, stochastic and environmental challenges having no or little phenotypic consequence. However, the extent of this robustness varies across individuals, for example the same mutation or treatment may only affect a subset of individuals. The overall objective of this project is to understand the cellular and molecular mechanisms that ...
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1
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TERMINÉ
Synthetic Cellular Signaling Circuits (SynSignal)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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10
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TERMINÉ
Miniature Insect Model for Active Learning (MINIMAL)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,
Biology provides the inspiration for a vision of small low-power devices that are able to learn rapidly and autonomously about environmental contingencies, enabling prediction and adaptive anticipatory action. Larval Drosophila have fewer than 10,000 neurons, yet express a variety of complex orientation and learning behaviours, including non-trivial anticipatory actions requiring context-dependent ...
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4
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TERMINÉ
PRIMES: Protein interaction machines in oncogenic EGF receptor signalling (PRIMES)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,
"PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit ...
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14
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TERMINÉ
Hearts and limbs: Linking morphometrics with 3D analysis of gene expression patterns (3D Gene Shape)
Date du début: 1 mai 2013, Date de fin: 9 août 2016,
Development of new imaging techniques, such as optical projection tomography (OPT), to visualize gene expression patterns within developing structures in a 3D framework has revolutionized developmental biology research. However, methods to precisely quantify these 3D expression distributions in a systematic manner are still lacking. We are developing a novel approach to combine OPT with Geometric ...
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1
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TERMINÉ
Systems neuroscience of Drosophila: from genes to circuits to behaviour (FLIACT)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Understanding how the brain works represents one of the greatest challenges in modern science. This question embraces mechanisms spanning multiple levels of description, from genes to biochemical pathways, from neurons to circuits, from circuit activities to adaptive behaviours. The goal of the FLiACT programme is to train young researchers in the concepts and techniques necessary to study integra ...
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11
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TERMINÉ
From Data to Models: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications (BIOPREDYN)
Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,
Currently, biologists are collecting enormous amounts of ‘omics’ data in a vast number of different databases. Predictive, data-driven computational models are needed to understand the complex, multi-scale biological networks underlying these high-throughput datasets. Such models are non-linear and contain many parameters, which are difficult (or impossible) to measure directly. Instead, parameter ...
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12
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TERMINÉ
Quantitative understanding of a living system and its engineering as a cellular organelle (CellDoctor)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2015,
The idea of harnessing living organisms for treating human diseases is not new but, so far, the majority of the living vectors used in human therapy are viruses which have the disadvantage of the limited number of genes and networks that can contain. Bacteria allow the cloning of complex networks and the possibility of making a large plethora of compounds, naturally or through careful redesign. On ...
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2
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TERMINÉ
Proteomics Research Infrastructure Maximising knowledge EXchange and access (XS) (PRIME-XS)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
Genome sequencing initiated a new age in biology. Now, the emphasis is on the biological interpretation of the genome: zooming on the biological functioning of the gene-products, i.e. the proteins, emerging into a filed termed proteomics. Protein levels depend not only on mRNA levels, but also on translational controls & regulated degradation, making the measurement of expression at the protein le ...
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12
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TERMINÉ
Engineering zinc fingers to target cancer hub genes (ZINC-HUBS)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2014,
"For the last ten years, protein engineering technologies have been developed to make zinc finger peptides to recognise a wide variety of user-defined DNA sequences. This has enabled the construction of synthetic transcription factors that can upregulate or repress target genes at will. More recently, synthetic zinc fingers have been linked to nucleases to direct double stranded breaks at desired ...
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4
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TERMINÉ
Synthetic gene regulatory networks for single-stripe gene expression (SynthStripe)
Date du début: 1 août 2012, Date de fin: 31 juil. 2014,
A pivotal question in developmental biology is how cellular gene regulatory networks can respond to a signalling molecule in a concentration-dependent manner. This can now be studied using the modern tools of synthetic biology, an emerging research field that applies engineering approaches to biological systems.This project aims to adapt and develop a band-forming model in E. coli. It will explore ...
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1
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TERMINÉ
Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)
Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,
Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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44
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TERMINÉ
In Vivo Imaging of Beta cell Receptors by Applied Nano Technology (VIBRANT)
Date du début: 1 juil. 2009, Date de fin: 30 juin 2013,
Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increas ...
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11
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TERMINÉ
Eukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferation (UNICELLSYS)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,
The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulation ...
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20
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TERMINÉ
PROteomics SPECification in Time and Space (PROSPECTS)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,
"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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11
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TERMINÉ
Modelling Joint Development: Integrating Biological and Mechanical Influences (MODELLING_JOINT_DEV)
Date du début: 1 nov. 2009, Date de fin: 31 août 2011,
"Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone. From the interzone, the synovial cavity develops. Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gra ...
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