3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Genetic interaction networks: From C. elegans to human disease (2-HIT)
Date du début: 1 sept. 2008, Date de fin: 30 avr. 2014,
"Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactio ...
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2
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TERMINÉ
Unraveling the mechanisms of odor coding and sent-tracking in Drosophila larvae (MnemoSmell)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
To survive and prosper, any motile organism must extract relevant cues from its external environment and convert them into coherent internal representations. Responses elicited by the flow of internal representations form the basis of adaptive behaviours. The overall goal of this project is to elucidate how olfactory signalling and behavioural decisions emerge from the integration of molecular and ...
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2
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TERMINÉ
The evolution of genetic robustness (2B-Robust)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,
Most genes are not required for viability. This robustness to mutation is a fundamental property of complex biological systems but the mechanism(s) underlying it and how it evolves is unclear. It has been proposed that robustness can result from genetic redundancy through gene duplication and the distributed nature of biological networks. The robustness of both yeast and C. elegans has been dissec ...
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