6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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15
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TERMINÉ
HEMatopoietic cell IDentity : genetic and epigenetic regulation in normal and malignant hematopoiesis (HEM_ID)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
In hematopoiesis, failure to maintain homeostasis and regenerative functions result in a multitude of hematological malignancies, including myelodysplastic syndromes, lymphomas and leukemias, that represent a medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been ...
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12
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TERMINÉ
Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition (RODAM)
Date du début: 1 janv. 2012, Date de fin: 30 sept. 2015,
"Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well ...
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9
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TERMINÉ
A Treatment-Oriented Research Project of NCL Disorders as a Major Cause of Dementia in Childhood (DEM-CHILD)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,
"The DEM-CHILD project focusses on the main cause for childhood dementia in Europe, the neuronal ceroid lipofuscinoses (NCLs). The NCLs are neurodegenerative diseases characterized by dementia, blindness, epilepsy and physical decline leading to an early death of the patients. Since no cure is currently available, these disorders represent a serious social, medical, and economic challenge.To date, ...
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13
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TERMINÉ
Integrated approaches to study gene regulation during cellular differentiation (InteGeR)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
Cellular differentiation from stem cells to fully functional mature cells is a multi step process executed by complex transcription programs. Once differentiated, cells must faithfully maintain their identity through cellular memory mechanisms. The utilisation of genetic information stored in linear DNA sequence occurs within the three dimensional context of chromatin, chromosomes and the nucleus, ...
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9
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TERMINÉ
Advanced affinity tools and technologies for high throughput studies of the human proteome (AffinityProteome)
Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,
High specificity affinity reagents (‘binders’) are essential probes for proteome research, enabling the detection and localisation of multiple proteins in tissues and fluids in health and disease, through the application of binder-based technologies (affinity proteomics). This proposal links the high throughput production of quality-controlled, recombinant binding molecules of different types (ant ...
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