9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Synthetic Cellular Signaling Circuits (SynSignal)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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10
Participants partenaires
TERMINÉ
Multidisciplinary training in evo-devo and neurobiology of marine animal models (NEPTUNE)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
NEPTUNE will train a new generation of biologists through cutting edge research on marine animal models. The network unites 8 leading European labs with complementary expertise in evolutionary developmental biology (EvoDevo), bioinformatics, functional neurobiology, and palaeontology; four leading visiting researchers from Europe and the US; a full partner from industry, Sigma-Aldrich, specialised ...
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8
Participants partenaires
TERMINÉ
Small RNA-guided complex machinery for epigenetic silencing (PISILENCE)
Date du début: 1 janv. 2011, Date de fin: 31 mai 2016,
Transposons are parasitic DNA elements that when activated can insert into new genomic locations, leading to genomeinstability. Animal germlines express a special class of small RNAs called piwi-interacting RNAs (piRNAs) which areimplicated in transposon silencing. In mammals, they are believed to promote DNA methylation of transposon-rich genomicregions. Mechanisms of piRNA biogenesis and functio ...
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1
Participant partenaire
TERMINÉ
New Technologies and Production Tools for Complex Protein Biologics (ComplexINC)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines fo ...
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8
Participants partenaires
TERMINÉ
New drugs targeting influenza virus polymerase (FLU-PHARM)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The 2009 H1N1 pandemic and the ongoing threat of highly pathogenic H5N1 strains have focused attention worldwide on the urgent need for effective anti-influenza drug options when the public is not protected by vaccination. The need is pressing since several circulating strains are resistant to currently stock-piled anti-neuraminidase drugs. In this project, we will exploit our recent advances in t ...
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12
Participants partenaires
TERMINÉ
Global positioning of TFIIIC and its involvement in extra-transcriptional processes (ExtraTF) (ExtraTF)
Date du début: 1 avr. 2013, Date de fin: 31 mars 2015,
Gene expression is regulated at many levels since changes in the expression pattern of certain genes might lead to the development of diseases such as cancer. Transcription is one of these regulation steps, orchestrated by transcription factors and RNA polymerases. Of these, RNA polymerase III (RNA Pol III) is responsible for transcribing small un-translated RNA molecules, such as tRNA. Transcript ...
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1
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TERMINÉ
Basal factor engineering and synthetic nucleosomal DNA super-template construction for pre-initiation complex assembly (PICengineering)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,
Initiation of RNA polymerase II (Pol II) transcription is activated by the assembly of preinitiation complex (PIC) onto gene promoters. PIC contains the largest general transcription factor (GTF), TFIID that comprises TATA box-binding protein (TBP). The binding of TBP to TATA promoter is rate-limiting step in PIC assembly and is stabilized by GTFs, TFIIA and TFIIB. TFIID also contains reader domai ...
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1
Participant partenaire
TERMINÉ
EMBRC preparatory phase (EMBRC)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,
The Preparatory Phase for a pan-European MARINE BIOLOGICAL RESOURCE CENTRE(EMBRC) research Infrastructure. This application focuses on the technical, legal, governance, and financial issues to prepare a memorandum of understanding to begin to construct EMBRC. It will build on existing Marine Biological Institutes and Research Centres which will be complemented with innovative components and pro ...
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12
Participants partenaires
TERMINÉ
A systems-level understanding of the novel principle in early mammalian development (MammalianDevelopment)
Date du début: 1 juil. 2008, Date de fin: 31 déc. 2013,
Early mammalian development is a unique process creating an extraembryonic structure. Despite its importance for understanding mammalian development and direct relevance to clinical practice, the mechanism underlying polarity establishment in the mammalian embryo has long been elusive. One of the major obstacles is the lack of description in molecular terms, since very few genes are known to speci ...
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