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16 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

Neovascular glaucoma (NVG) is a very aggressive and rare type of glaucoma: yet, it contributes disproportionately to blindness from all eye diseases. NVG is also the second most common cause for the removal of the eye-ball across all eye diseases, usually because of intractable pain. The major cause of NVG is Ischaemic Central Retinal Vein Occlusion (CRVO) leading to neovascularisation, obstructio ...
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 9

 TERMINÉ 

Lipid Signaling at the Glutamatergic Synapse: Involvement in Brain Network Function and Psychiatric Disorders (LiPsyD)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

We have recently reported on a novel mode of modulation of neuronal transmission at the glutamatergic junction. This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors. This is in turn controlled by a molecule which we named plasticity related gene-1 (PRG-1, Bräuer et al., Nat Neurosci 2003) from the postsynaptic side (Trimbuch et al., Cell 2009). PRG-1 is ...
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 1

 TERMINÉ 

NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes (NUTRIMMUNE)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intestinal infections or to chronic inflammation causing debilitating human diseases such as inflammatory bowel diseases or inflam ...
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 2

 TERMINÉ 

Quantitative Imaging of Liver Fibrosis and Fibrogenesis (LiverFibrosisImaging)

Date du début: 1 août 2012, Date de fin: 31 juil. 2017,

Chronic liver disease can progress to cirrhosis, with death due to liver failure and cancer. Cirrhosis prevalence in the EU is 0.5%-1%. However, development of therapies that prevent progression to cirrhosis is hampered by the lack of a sensitive, non-invasive method to quantify fibrosis or fibrosis progression (fibrogenesis). Liver biopsy 1) is risky, 2) shows high sampling variability, and 3) is ...
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 3

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

Role of the mitochondrial anti-viral signaling protein in sepsis (MAVS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Severe sepsis is an important complication of infections and one of the leading causes of morbidity and mortality. For the countries of the European Union it is estimated that approximately 600,000 cases and more than 150,000 deaths occur from sepsis per year. Currently, no approved treatment options are available for the therapy of septic shock in humans.This research proposal intends to investi ...
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 1

 TERMINÉ 

BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry (BlueGenics)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, ...
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 18

 TERMINÉ 

From gene to biomineral: Biosynthesis and application of sponge biosilica (BIOSILICA)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

"During the last decade, the principles of biomineralization have increasingly attracted multidisciplinary scientific attention, not only because they touch the interface between the organic/inorganic world but also because they offer fascinating bioinspired solutions to notorious problems in the fields of biotechnology and medicine. However, only one group of animals has the necessary genetic/enz ...
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 1

 TERMINÉ 

Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds (Bio-Scaffolds)

Date du début: 1 juin 2013, Date de fin: 31 mai 2016,

The application of rapid prototyping techniques has become a new trend in the fabrication of customized scaffolds for tissue regeneration or repair. The aim of the proposed project is to provide novel solutions for bottle-neck problems currently faced in establishing the corresponding processing chain, which encounter, among others, the extraction of essential geometry data of the damaged tissue f ...
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 5

 TERMINÉ 

European-Chinese Research Staff Exchange Cluster on Marine Biotechnology (MARBIOTEC*EU-CN*)

Date du début: 1 août 2010, Date de fin: 31 juil. 2015,

Marine biotechnology is one of the most exciting emerging fields of technology. It becomes more and more important in many areas of application such as the production of new drugs, food ingredients, agrochemicals, and cosmetics. More recently, it was found that some products of marine organisms are also of extreme importance in the rapidly growing field of nano(bio)technology, another technology o ...
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 3

 TERMINÉ 

Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme (ALPHA-MAN)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2014,

Alpha-Mannosidosis is a rare Lysosomal Storage Disorder with a worldwide incidence of about 1:500 000. This orphan and devastating disease is caused by the deficiency of the lysosomal alpha-mannosidase (LAMAN) which is responsible for the intralysosomal degradation of mannosyl linked oligosaccharides. To date no causative treatment for alpha-Mannosidosis is available and since most of the children ...
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 12

 TERMINÉ 

High-Density Peptide MicroArrays and Parallel On-line Detection of Peptide-Ligand Interactions (PepChipOmics)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Proteins are crucial structural and functional elements of life, and frequent targets of intervention. Short protein sequences, conventionally defined as peptides, have emerged as indispensable tools in biotechnology: peptides may represent short linear protein structures, and in some cases they even mimic more complex discontinuous structures. Custom-made synthetic peptides cost down to ca. 30 E ...
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 7

 TERMINÉ 

Development and analysis of polymer based multi-functional bactericidal materials (EMBEK1)

Date du début: 1 août 2008, Date de fin: 31 juil. 2011,

90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients of ...
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 11

 TERMINÉ 

Prospective cohort studies of children with substantial medical diagnostic exposure (CHILD-MED-RAD)

Date du début: 1 sept. 2008, Date de fin: 30 nov. 2009,

The growing use of diagnostic X-rays and of high-dose techniques (CT, interventions) in children and adolescents is a topic of concern in radiological protection. Studies of other populations indicate that children are generally more sensitive to health effects of radiation than adults. In addition, children have a longer life-span to express any radiation-related health effect and, because of the ...
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 10