5 projets européens trouvés
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TERMINÉ
Inborn errors of innate immunity: systems genomics route to the core of the immune system (ImmunoCore)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
The ultimate relevance of a component of the innate immune system in human physiology is uncovered by the consequence of mutations in the associated gene. We have integrated systems genomics tools to mine, uncover and pathway-map primary deficiencies with high efficiency. Primary immunodeficiency disorders involving innate immunity are characterized by recurrent and life-threatening infections. Im ...
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TERMINÉ
BERG – Biomedical Epigenomics Research Group (BERG)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2017,
Significance: The genetic code of the DNA provides a universal building plan for the cell’s molecular machinery. But a second code is needed to control the complexity of the human body, organizing 100 billion cells with identical genomes into 200 specialized cell types. This second code is called “epigenetic”. Defects in the epigenetic code play an important role in cancer, and they create an oppo ...
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TERMINÉ
DNA damage response: ATMIN regulated non-canonical ATM activation (NONCANATM)
Date du début: 1 sept. 2012, Date de fin: 31 août 2016,
The checkpoint kinase ATM (Ataxia Telangiectasia Mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. ATMIN (for ATM INteractor) is a cofactor for ATM that shares functional homologies with another cofactor, NBS1. Whereas NBS1 is required for ATM function after induction of double-stand breaks (DSBs), ATMIN is essential for ATM ...
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TERMINÉ
A proteomic screen to identify cytoplasmic DNA sensor proteins mediating type I Interferon production (INNATEDNASENSOR)
Date du début: 20 déc. 2013, Date de fin: 19 déc. 2015,
Detection of pathogens by the innate immune system depends on the recognition of microbial components by dedicated receptors. During viral and bacterial infections, pathogen-derived nucleic acids are recognized by innate receptors resulting in the production of type I IFNs and inflammatory cytokines. While it is established that cytoplasmic delivery of viral, bacterial and even host DNA triggers t ...
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TERMINÉ
Acute Inflammation Resolution by Soluble Human Inhibitory Protein (AIRSHIP)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2013,
"Acute inflammatory processes are associated with infections as well as autoimmune flares at the basis of a variety of human diseases. While the molecular components and the logic of pro-inflammatory program are relatively well understood, less is known about the molecular mechanism of resolution, governing the termination of inflammatory responses. In the course of carrying out the i-FIVE ERC gra ...
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