12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Cardiac Connective Tissue: Beat-by-Beat Relevance for Heart Function in Health and Disease (CARDIONECT)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2019,
Cardiac connective tissue is regarded as passive in terms of cardiac electro-mechanics. However, recent evidence confirms that fibroblasts interact directly with cardiac muscle cells in a way that is likely to affect their beat-by-beat activity.To overcome limitations of traditional approaches to exploring these interactions in native tissue, we will build and explore murine models that express fu ...
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3
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TERMINÉ
Brain-gut interactions in Drosophila melanogaster (BrainGutTalk)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but studies aimed at identifying the signals involved are faced with daunting neuroanatomical complexity: there are as many as 500 million neurons in the human gut. Drosophila should provide a simple and genetically amenable alternative, but both its autonomic nervous system and the signalling significance of its ...
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2
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TERMINÉ
Rapid reliable volume status and ventricular function assessment by non-specialist staff using innovative imaging in clinical practice (SURESCAN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
Many urgent medical settings require immediate assessment of intravascular volume status to initiate treatment and non-invasive monitoring of progressive changes in volume. Other diagnostic medical scenarios require urgent identification of impairment of ventricular function, to select appropriate initial treatment. With standard approaches, accessing this information quantitatively requires exper ...
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2
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TERMINÉ
Genetics and epigenetics of Type 2 Diabetes physiology (GEPIDIAB)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,
"Failure to elucidate Type 2 Diabetes (T2D) physiology frustrates efforts to improve therapeutics. Although GWAS has identified 40 T2D genes, mostly expressed in pancreatic beta-cells, this explains no more than 10% of T2D inheritance. Up to 5% of T2D patients have dominantly inherited maturity-onset diabetes of the young (MODY), characterized by beta-cell dysfunction. Elucidating the genetics of ...
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3
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TERMINÉ
Elucidation of the molecular and functional basis of disease phenotypes in the rat model (ELABORATE)
Date du début: 1 juin 2011, Date de fin: 31 mai 2017,
Recent genetic studies have identified hundreds of susceptibility genes for common human diseases but genetic effects are small and identifying underlying mechanisms remains challenging. Rodent models offer significant advantages for analysis of disease phenotypes. Advances in genome resources and gene targeting have increased the attractiveness of the rat model for genetic studies but progress ha ...
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3
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TERMINÉ
The genetic basis of meningococcal and other life threatening bacterial infections of childhood (EUCLIDS)
Date du début: 1 déc. 2011, Date de fin: 31 mai 2017,
Bacterial infection is the major cause of disability and death in children worldwide. We will use meningococcal disease (MD) as a model to understand genetic factors underlying susceptibility and severity of childhood bacterial infection which will then be applied to other childhood infections. We have established cohorts of patients with MD in Central and Southern Europe (CE,SE), UK and Africa as ...
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16
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TERMINÉ
Cell cycle regulation of ES cell identity and reprogramming potential (REPLENICHE)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,
"Pluripotent embryonic stem (ES) and germ (EG) cells differ from other stem cells in several respects. They display a characteristically ‘compressed’ cell cycle in which G1 is shortened, contain a high proportion of cells in DNA synthesis (S)-phase and lack several cell cycle checkpoints. This unusual cell cycle signature is important for maintaining their identity since cell cycle arrest, or leng ...
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2
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TERMINÉ
Supporting Low-cost Intervention For disEase control (SUPPORTING LIFE)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,
In developing countries, most of the 11 million deaths per year of children under the age five years occur in areas where adequate medical care is not available. In Malawi the under-five mortality rate is 133 per 1,000 live births. First-level health facilities - the closest health care services available to most sick children in developing countries are generally run by local medical physicians.T ...
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10
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TERMINÉ
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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32
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TERMINÉ
Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
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46
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TERMINÉ
Dengue research Framework for Resisting Epidemics in Europe (DENFREE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
"WHO estimates that one of the main consequences of global warming will be an increased burden of vector-borne diseases. Among these, dengue appears to be particularly problematic, with tens of millions of cases of dengue fever estimated to occur annually, including up to 500,000 cases of the life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent years, the global burden of den ...
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15
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TERMINÉ
A functional analysis of Listeria and Staphylococcus lipoteichoic acid (LISTA-LTA)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
This proposal aims to provide insight into the physiological function of lipoteichoic acid (LTA) in the two Gram-positive bacterial pathogens Listeria monocytogenes and Staphylococcus aureus. LTA is an essential component of the envelope in Gram-positive bacteria. While the chemical structure of this polymer was elucidated several decades ago, the key genetic determinants for its synthesis have be ...
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