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Plus de 40 projets européens trouvés

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 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

European Prevention of Alzheimer’s Dementia Consortium (EPAD)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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 40

 TERMINÉ 

Novel materials architecture based on atomically thin crystals (HETERO2D)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2019,

We propose a new paradigm in materials science – heterostructures based on two-dimensional atomic crystals (and their hybrids with metallic and semiconducting quantum dots and nanostructures), and develop several devices which are based on such concept. Two-dimensional (2D) atomic crystals (such as graphene, monolayers of boron nitride, molybdenum disulphide, etc) possess a number of exciting prop ...
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 3

 TERMINÉ 

Epistemic intersections in early modern England: the place of literature (KNOWING)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,

"This project uncovers the interface between imaginative literature and epistemology in its wider sense in early modern England (1500-1700). This period of intense literary production also saw the cultural forces of humanism and the Reformation collide; crucial shifts in the law; scientific advancement; and dramatic expansion in trade and travel. At stake across the board was knowledge: its theori ...
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 1

 TERMINÉ 

COLONISATION AND CULTURAL DIVERSIFICATION IN UNFAMILIAR LANDSCAPES (UP-NORTH)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,

This project explores the relationship between climate change and human behaviour. During the harshest conditions of the last ice age European human populations abandoned northern latitudes, with their range contracting to southern regions. By the time ice sheets retreated and large areas of land became available for resettlement there had been a hiatus of at least 7000 years. This project examin ...
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 3

 TERMINÉ 

Living the Law: Transitional Justice in Colombia (JUSTCOLOMB)

Date du début: 1 avr. 2015, Date de fin: 1 sept. 2019,

The proposed project “Living the Law: Transitional Justice in Colombia” is intended to help the researcher to attain a leading independent position as a socio-legal scholar.The researcher, a social anthropologist, will acquire new skills and knowledge in empirical socio-legal research and will return to her host institution equipped to teach and publish in the still under-represented field of soci ...
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 1

 TERMINÉ 

Genius before Romanticism: Ingenuity in Early Modern Art and Science (GBR)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

"Genius before Romanticism: Ingenuity in Early Modern Art and ScienceWhat existed in the European imagination before the Romantic concept of ‘genius’? This five-year project will examine notions of unique talent, heightened imagination and extraordinary creativity in art and science by exploring the language, theories, practices and products of ingenium (ingenuity) ca. 1450-ca. 1750. Drawing on ...
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 1

 TERMINÉ 

Adaptation, Dispersals and Phenotype: understanding the roles of climate, natural selection and energetics in shaping global hunter-gatherer adaptability (ADaPt)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

Relative to other species, humans are characterised by considerable biological diversity despite genetic homogeneity. This diversity is reflected in skeletal variation, but we lack sufficient understanding of the underlying mechanisms to adequately interpret the archaeological record. The proposed research will address problems in our current understanding of the origins of human variation in the ...
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 1

 TERMINÉ 

The genomic architecture of speciation in tropical butterflies (SpeciationGenetics)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

These are exciting times for speciation research with a wealth of recent theoretical and empirical advances, but there is much we still do not understand. The Heliconius butterflies offer an excellent opportunity to gain novel insights into the genetic architecture of speciation and its genomic consequences, by integrating genomic data with the well-studied ecological and behavioural processes tha ...
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 1

 TERMINÉ 

Rethinking Urban Nature (RUN)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

This ground-breaking project will challenge existing understandings of urban nature using an innovative interdisciplinary framework in a comparative international context. The project provides a new theoretical approach that moves beyond existing approaches to provide a novel synthesis between advances in urban ecology and original insights into cultural and political dimensions to the production ...
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 2

 TERMINÉ 

Non-invasive genomic analysis of cancer using circulating tumour DNA (CancerExomesInPlasma)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Non-invasive genomic analysis of cancer can revolutionize the study of tumour evolution, heterogeneity, and drug resistance. Clinically applied, this can transform current practice in cancer diagnosis and management. Cell-free DNA in plasma contains tumour-specific sequences. This circulating tumour DNA (ctDNA) is a promising source of genomic and diagnostic information, readily accessible non-inv ...
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 1

 TERMINÉ 

Production Networks in Macroeconomics (MACRONETS)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"A modern economy is an intricately linked web of specialized production units, each relying on the flow of inputs from their suppliers to produce their own output which, in turn, is routed towards other downstream units. Recent work in economics stresses that the structure of this production network is key in determining whether and how microeconomic shocks can propagate throughout the economy an ...
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 1

 TERMINÉ 

Ultra-low dose of IL-2 for the treatment of recently diagnosed type 1 diabetes (DIABIL-2)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2019,

ConceptThe discovery of regulatory T cells (Tregs) has revolutionized our understanding of autoimmune diseases. As T1D is caused by the failure of Tregs to block autoimmune destruction of pancreatic ß-cells, Treg stimulation has the potential to stop the process, preserve ß-cells’ insulin secretion, and likewise prevent or delay disease progression and improve clinical outcome for patients.Backgro ...
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 7

 TERMINÉ 

The chemical biology of RNA G-quadruplexes (RNAQUAD)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"For over a decade, our research programme has focused on the chemical biology of nucleic acids. The structure of nucleic acids is key to their biological functions, and the four-stranded guanine rich class of structures called G-quadruplexes constitute a particularly intriguing motif. Recent evidence suggests a role for G-quadruplex (G4) structures in RNA leaving their fundamental importance in b ...
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 1

 TERMINÉ 

Evolutionary genetics of transcription factor binding in closely related mammals (EvoGeneticsTFBinding)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

The genetic differences found in gene regulatory regions are the largest contributing factor to the diversity of phenotypes within and between mammalian species. However, the micro-evolutionary mechanisms active in closely-related species remain poorly explored, particularly in mammals.In Aim 1, we will exploit five recently sequenced mouse species to determine how often genetic sequence differenc ...
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 1

 TERMINÉ 

Programmable Plastics (DUPLEX)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2019,

The unique properties of nucleic acids have made them the material of choice for complex nanofabrication. High fidelity formation of duplexes via non-covalent interactions between complementary sequences provides a straightforward approach to molecular programming of multicomponent self-assembly processes. The structure of the nucleic acid backbone and bases can be changed without destroying these ...
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 2

 TERMINÉ 

Water Isotopes of Hydrated Minerals (WIHM) (WIHM)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Water is fundamental to life as we know it, and the current strategy for the search of life on Mars is to “follow the water”. Much of the water on Mars exists today in the form of hydrated minerals that incorporate molecular water or hydroxyl into their crystalline structure. Hydrated minerals provide a tool for studying the past history of the hydrosphere on Mars as well as Earth. Oxygen and hyd ...
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 1

 TERMINÉ 

Hydrodynamical simulations of protoplanetary discs in the era of ALMA imaging (DISCSIM)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"This is a proposal for an ambitious programme of state of the art hydrodynamical simulations, designed to answer some key questions about the role of disc self-gravity in planet formation. The programme is also designed so as to maximize the synergy with the new observational constraints from high resolution imaging data from the Atacama Large Millimetre Array that will become available over t ...
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 1

 TERMINÉ 

Determining Physical Properties of Heterogeneous Protein Complexes in Small Volumes (PhysProt)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

The objective of this proposal is to probe in aqueous solution protein complexes which are both heterogeneous and possess highly variable stoichiometries. The study of heterogeneous protein systems by conventional means is very challenging since most current biophysical methods perform best for pure solutions of isolated components - yet proteins exert in the majority of cases their biological fun ...
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 1

 TERMINÉ 

Synergistic Modelling of Molecular Effects via Chemical and Biological Data Integration (MIXTURE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"While conventionally effects of a chemical structure on a biological system have been determined for individual compounds, one at a time, it is now becoming apparent that biological effects of compound combination are not additive, but often conditional (antagonistic or synergistic) in nature. This phenomenon is of relevance both in the medicinal context (where drugs can be combined to have a syn ...
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 1

 TERMINÉ 

Membrane-triggered actin polymerisation: molecular mechanisms and morphogenesis (MembranesActin)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2018,

Changes in cell shape, movement and vesicle traffic all require remodelling of the actin cytoskeleton. While the actin filament remains chemically the same, the filaments are assembled differently for different functions, e.g. long, bundled, parallel filaments in filopodia and short meshworks in endocytosis. The membrane appears to function as an organising surface where proteins come together to ...
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 1

 TERMINÉ 

Creating a habitable planet: the roles of accretion, core formation and plate tectonics (HABITABLEPLANET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

The Earth formed ~ 4.5 billion years ago, from accreting particles of dust and primitive meteorites. It is the only habitable planet in our solar system and has a unique history of extended accretion and core formation coupled with active plate tectonics. Accretion and core formation would have defined the initial elemental composition of the Earth’s interior whereas plate tectonic processes contr ...
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 2

 TERMINÉ 

STATISTICAL ANALYSIS OF PROTEIN SEQUENCES TO INFER 3D STRUCTURE AND FUNCTION (EVO-COUPLINGS)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

"Across natural science, experimental techniques that generate large and inherently noisy datasets are currently being developed. As these techniques gain popularity, the potential impact of inference methods that enable useful information to be extracted from the resulting data is large. However, different experiments generate datasets that are afflicted by different types of noise, and require d ...
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 1

 TERMINÉ 

Hierarchical Carbon Nanomaterials (HIENA)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

"Over the past years, carbon nanomaterial such as graphene and carbon nanotubes (CNTs) have attracted the interest of scientists, because some of their properties are unlike any other engineering material. Individual graphene sheets and CNTs have shown a Youngs Modulus of 1 TPa and a tensile strength of 100 GPa, hereby exceeding steel at only a fraction of its weight. Further, they offer high curr ...
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 1

 TERMINÉ 

Vaccination In Atherosclerosis (VIA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Cardiovascular disease (CVD) is still a leading cause of death in the European Union (EU) accounting for nearly half of all deaths in Europe (48%). In addition, CVD complications lead to a vast number of hospitalizations and thus to a great burden of health care costs in the EU. Atherosclerosis and its final complication, plaque rupture and subsequent infarct in heart or brain, is the main underl ...
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 12

 TERMINÉ 

Stratospheric and upper tropospheric processes for better climate predictions (StratoClim)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

StratoClim will produce more reliable projections of climate change and stratospheric ozone by a better understanding and improved representation of key processes in the Upper Troposphere and Stratosphere (UTS). This will be achieved by an integrated approach bridging observations from dedicated field activities, process modelling on all scales, and global modelling with a suite of chemistry clima ...
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 30

 TERMINÉ 

Universal Framework for Charge Transport in Quantum Dot Systems (UNIQDS)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

The field of quantum dots (QDs) is one of the major growth areas in interdisciplinary field of physics, materials, chemistry, and engineering for the exploration of fundamental physical properties and potential/new functionalities. This will serve as a basis for creation of unique applications such as new display/lighting, photovoltaic device, TFTs and image sensors. However, there are serious imp ...
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 2

 TERMINÉ 

Evolutionary strategy for plant breeding (EVOBREED)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"Large proportions of eukaryotic genomes consist of transposable elements (TEs), predominantly of retrotransposons. They are generally considered as intra-chromosomal parasites. However, their periodical activity bursts influenced organization of host genomes and contributed to beneficial traits. Remarkably, number of transposon generated phenotypic innovations was subsequently selected by humans ...
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 1

 TERMINÉ 

Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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 15

 TERMINÉ 

Visual Representations of the Third Plague Pandemic (VR3PP)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The project will investigate how the emergence of photography as a new technology played a pivotal role in the wider acceptance of bacteriological explanations of pestilence in the course of the third plague pandemic (1855-1959) and how it transformed public consciousness of infectious disease, hygiene, and the role of international cooperation in the protection of public health, by establishing ...
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 1

 TERMINÉ 

Health Resilience and Economic Shocks: Analysis of Quasi-Natural Experiments Using Multi-Level Modelling (HRES)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"One of the greatest contemporary challenges for the social sciences is to understand the human costs of the ongoing financial, economic, and debt crises that began to emerge in Europe in 2007. While much attention has focused on the economic dimensions of recessions in Europe, very little work is being done to analyse the consequences of these events for health and well-being. There are widesprea ...
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 2

 TERMINÉ 

Identification of Novel Targeted Therapies for Renal Cancer (ONCOTREAT)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Overall, kidney cancers are the eighth most common cancer and the incidence of the most common form (renal cell carcinoma, RCC) has been increasing steadily over the past 30 years. If detected early, surgical removal of RCC can be curative but the prognosis for metastatic disease is very poor. RCC is resistant to conventional therapy and recently introduced targeted therapies form the mainstay of ...
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 2

 TERMINÉ 

"Sources, Interaction with Matter, Detection and Analysis of Low Energy Electrons 2" (SIMDALEE2)

Date du début: 1 sept. 2014, Date de fin: 31 août 2018,

"The purpose of the SIMDALEE2 (Sources, Interaction with Matter, Detection and Analysis of Low Energy Electrons) network is to establish a world-class research training platform for the science and technology of nanoscale manipulation and analysis using low energy electrons. Apart from an effective and well-structured training programme, the network will pursue the following scientific goals: (1) ...
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 12

 TERMINÉ 

UNCONVENTIONAL SUPERCONDUCTIVITY FROM A MOTT INSULATING PARENT MATERIAL (SUPERCONDUCTINGMOTT)

Date du début: 1 août 2013, Date de fin: 31 juil. 2018,

"The mystery of unconventional superconductivity is one that is yet to be solved after decades of research. Better superconductors will have a crucial role in improved energy efficient applications such as power storage and transmission. While the highest temperature superconductors to date are the copper oxide family of antiferromagnetic Mott insulators, the origin of unconventional superconducti ...
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 1

 TERMINÉ 

"Family life courses, intergenerational exchanges and later life health" (FAMHEALTH)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,

"The overall aim of this research programme is to uncover how family life courses influence health and well-being in later adulthood, whether family related strengths or disadvantages relevant to health offset or compound socio-economic sources of disadvantage, and the extent to which these associations are influenced by societal factors. An important element will be to consider the role of interg ...
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 4

 TERMINÉ 

Recorded Muslim sermons from East Africa (RMSEA)

Date du début: 8 mai 2012, Date de fin: 20 juin 2018,

The proposed project examines recordings of Swahili-language Muslim sermons from Uganda, Kenya and Tanzania. Muslims form significant minorities in these countries; their relations to Christians and government have become tenser due to the rise of reformist and political Islam. Recorded sermons reflect a great variety of opinions on reformism and on Muslim history, politics and social life. They o ...
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 1

 TERMINÉ 

Specialisable, Programmable, Efficient and Robust Microprocessors (SPEAR)

Date du début: 1 sept. 2012, Date de fin: 31 mai 2018,

The development of faster, cheaper and smaller transistors has been the driving force behind the exponential growth in computing power over the past 50 years. While our ability to fabricate better transistors has not yet ceased, continuing to translate these advances into better system-level performance is now a major challenge. This proposal seeks to research a new approach to building programmab ...
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 1

 TERMINÉ 

The role of symplastic communication during root development (symdev)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

The symplastic route composed of plasmodesmata (PD) channels and the transporting phloem tissue (rich in PD) is the major pathway for carbon allocation in plants. How the symplastic transport route is formed during plant ontogeny and what is its significance in conducting and distributing morhogenetic signals to the growing organs is poorly understood at the moment and is addressed here. My labora ...
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 2

 TERMINÉ 

Investigating Hereditary Cancer Predisposition – a combined genomics approach (IHCAP)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"Background: Hereditary cancer is an important cause of morbidity and mortality and over the last 20 years, the majority of highly penetrant risk alleles such as BRCA1, BRCA2 in breast cancer and APC, MLH1, MSH2 in colon cancer have been identified. However, there are many men and women who have a strong family of cancer for whom we cannot provide answers because no mutation is found in known gene ...
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 1