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14 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Understanding the roles of kainate receptors in the hippocampus (HippoKAR)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Kainate receptors (KARs) are often regarded as the last frontier of glutamate receptor research, since much less is known about their physiological roles compared with that of the other glutamate receptor subtypes. This field of research is very important not just because of the unique role that KARs play in neuronal function, including specific forms of synaptic plasticity, but because of the inc ...
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 1

 TERMINÉ 

Assembling biomembranes: fundamentals of membrane transporter folding and creation of synthetic modules (MEMSEMBLE)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2018,

Self-assembly is a hallmark of Biology. We are far from a complete understanding of this natural assembly, which in turn limits our ability to mimic biological construction in the bioengineering of tuneable synthetic systems.This proposal addresses the major challenge of membrane protein folding. Here, I intend to make a step change to my pioneering biophysical studies and investigate co-translati ...
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 2

 TERMINÉ 

Cardio Renal Paradigms ElucidateD through an International Exchange ScheMe (CARPEDIEM)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

CARPEDIEM combines a unique approach and common interest to employ novel sophisticated technologies to understand the relationship between oxygen deprived tissues (hypoxia) and sympathetic hyperactivity in cardiorenal pathology.Cardiovascular diseases are increasing in epidemic proportions globally. Hence there is an essential need for novel insights, ultimately leading to new treatments. The conn ...
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 3

 TERMINÉ 

Synthetic Cellular Signaling Circuits (SynSignal)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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 10

 TERMINÉ 

Bright Farm by Precision Livestock Farming (EU-PLF)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The objective of the EU-PLF project is to deliver a validated Blueprint for an animal and farm-centric approach to innovative livestock farming in Europe proven through extensive field studies. This blueprint represents a manual for farmers and their surrounding industry including high tech SME’s and other stakeholders. It is a reference tool offering pragmatic guidance on how Precision Livestock ...
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 20

 TERMINÉ 

Silicon transport proteins in biological nanoscience and synthetic biology (IMPLANT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

"This interdisciplinary proposal will investigate whether the activity of a unique family of membrane transport proteins can be harnessed to develop novel strategies for the bioinspired fabrication of nanoscale materials and provide new directions in synthetic biology. Silicon transporters (SITs) are integral membrane proteins that were first identified in the diatoms, single–celled eukaryotic alg ...
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 1

 TERMINÉ 

The spatiotemporal organization of T cell signaling as a regulator of T cell function (T cell signaling)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

Understanding how cellular activation occurs in complex signaling networks is an important challenge in particular in multi-genic diseases such as autoimmune disease, type II diabetes, and cancer. A critical component of signaling complexity is that proteins inside live cells enrich at particular locations and times. Co-enrichment of two proteins enhances their interaction efficiency. At the syste ...
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 1

 TERMINÉ 

Memory bias and affective state: a new cognitive indicator of animal affect (MEMORAT)

Date du début: 1 sept. 2014, Date de fin: 31 août 2016,

"Modelling depression in animals has been a key aim of biomedical research for decades. However, current animal models of depression are increasingly questioned, & standard animal testing situations model only a few symptoms of the disease. To better assess animal depression, a broader set of psychological, neuroanatomical & cognitive alterations evident in depressed patients needs to be considere ...
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 1

 TERMINÉ 

The synaptic development of cortical circuitry in the young brain (Young Minds)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

The neuronal circuits that underlie higher brain function are created and refined early in life. Since early life experiences strongly influence the circuit maturation process, every single person is subject to the lifelong impact of their neonatal sensory environment. My research investigates when and how specific neuronal circuits form and the impact of sensory experience on circuit maturation. ...
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 1

 TERMINÉ 

Mechanics of ESCRT-III mediated membrane scission (MEM_FIZZ)

Date du début: 1 oct. 2010, Date de fin: 31 janv. 2016,

Cellular processes such as cytokinesis, the budding of enveloped retrovirus (e.g. HIV-1), and multivesicular biogenesis have direct links to several human diseases including carcinogenesis and neuro-degeration etc. While seemingly unrelated, these processes all involve membrane abscission for generating two newly formed membrane bound structures - a process aided by the cytosolic proteins collecti ...
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 1

 TERMINÉ 

Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in the early clinical development (PHARMA-COG)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision bef ...
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 38

 TERMINÉ 

The coordination of dendritic spine morphogenesis and function during synaptic plasticity and pathology (MORPHINGSYNAPSES)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,

Long-term synaptic plasticity is believed to underlie learning and memory and also the tuning of neural circuitry during development. Plasticity of excitatory synapses involves both changes in the function and morphology of dendritic spines, small actin-rich, dynamic protrusions that are the sites of excitatory neurotransmission. The coordination of the structure and function of dendritic spines ...
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 1

 TERMINÉ 

Companion Animals multisectoriaL interprofessionaL and Interdisciplinary Strategic Think tank On zoonoses (CALLISTO)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

Since more and increasingly different species of animals are kept as companions one has to face the fact that apart from the well documented positive effects of human-animal interaction there are negative consequences as well. CALLISTO will focus on the risks of zoonotic infectious diseases associated with companion animals. To do so, we will form a multidisciplinary, multisectorial and interprofe ...
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 9