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TERMINÉ
Interactions of Breast Cancer Cells with Macrophages in Controlled 3D in vitro Microenvironments (Cancer-3Dmatrix-EGF)
Date du début: 1 avr. 2011, Date de fin: 1 oct. 2015,
The leading cause of death for cancer patients is metastasis. During metastasis, cancer cells interact with various molecules and cells. It has been shown that a group of macrophages facilitates metastasis. Our goal is to determine the mechanism of interaction between epidermal growth (EGF) produced by macrophages and epidermal growth factor receptor (EGFR) expressed by breast cancer cells.Soluble ...
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TERMINÉ
Investigating the Role of Abnormal Hemichannel Activities of Cx26 Mutations on Epidermal Keratinocyte Calcium Homeostasis and Differentiation (SkinConnection)
Date du début: 1 mars 2011, Date de fin: 30 sept. 2015,
The skin protects the body against environmental insults and to function properly, epidermal keratinocytes maintain a perfect balance between proliferation and differentiation. Alteration of this balance leads to disorders. Some of these diseases are linked to connexin (Cx) mutations. Connexins are widely expressed in all layers of the epidermis but exact roles of connexins in the epidermis are no ...
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