8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders (COSYN)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity. Our aims are: (1) Understand comorbidity by ...
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14
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TERMINÉ
Deciphering inter- and intracellular signalling in schizophrenia (IN-SENS)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
IN-SENS is an interdisciplinary, cutting-edge European industry-academia collaborative effort for a novel training of scientists in molecular psychiatry with the prospect of discovering the biology of schizophrenia and actively promote drug discovery. Mental illnesses are a major burden to patients, relatives, and public health worldwide. IN-SENS therefore aims to profoundly change the academic-in ...
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16
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TERMINÉ
The Human Brain Project (HBP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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116
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TERMINÉ
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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19
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TERMINÉ
European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,
"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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19
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TERMINÉ
Timing and plasticity in the olivo-cerebellar system (CEREBNET)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,
"Training young researchers to form the new generation of scientists is a must for our society. In this project we will use a multidisciplinary approach to investigate neuronal and circuit functions in the cerebellar network, which plays a critical role in sensori-motor control and is probably also involved in higher cognitive functions. The project will focus on timing and plasticity in the netwo ...
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7
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TERMINÉ
BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
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14
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TERMINÉ
Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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