2 projets européens trouvés
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TERMINÉ
Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes (T2DSystems)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies ...
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TERMINÉ
Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes (BetaBat)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose me ...
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