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Plus de 40 projets européens trouvés

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 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 TERMINÉ 

Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial (PAPA-ARTIS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

 TERMINÉ 

Molecule-to-man pain network (PAIN-Net)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer p ...
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 13

 TERMINÉ 

EURopean Endeavour for Chimeric Antigen Receptor Therapies (EURE-CART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing ...
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 11

 TERMINÉ 

Smart optical and ultrasound diagnostics of breast cancer (SOLUS)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

SOLUS is a trans-disciplinary 48-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in their fields, to develop an innovative non-invasive, point-of-care, low-cost, easy-to-operate, multi-modal imaging system (diffuse optics and ultrasounds/shear wave elastograp ...
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 10

 TERMINÉ 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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 27

 TERMINÉ 

Beta Cell Generation by Stem Cell-Derived Implants in Diabetes (BetaCellTherapy)

Date du début: 1 déc. 2015, Date de fin: 31 août 2020,

Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases ha ...
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 8

 TERMINÉ 

Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Due to an aging population and the spiralling cost of brain disease in Europe and beyond, EDEN2020 aims to develop the gold standard for one-stop diagnosis and minimally invasive treatment in neurosurgery. Supported by a clear business case, it will exploit the unique track record of leading research institutions and key industrial players in the field of surgical robotics to overcome the current ...
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 9

 TERMINÉ 

European Security in Health Data Exchange (SHiELD)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

SHiELD will unlock the value of health data to European citizens and businesses by overcoming security and regulatory challenges that today prevent this data being exchanged with those who need it. This will make it possible to provide better health care to mobile citizens across European borders, and facilitate legitimate commercial uses of health data.The exchange of health data is already possi ...
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 11

 TERMINÉ 

DITAS: Data-intensive applications Improvement by moving daTA and computation in mixed cloud/fog environmentS (DITAS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

There is an increasing need to develop data intensive applications able to manage more and more amounts of data coming from distributed and heterogeneous sources effectively, quickly, correctly, and securely. However, the current adoption of Cloud Computing paradigm is not fully appropriate to store and analyse such data: latency, security, and compliance are still significant barriers. At the sa ...
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 9

 TERMINÉ 

Neurovascular Interactions and Pathfinding in the Spinal Motor System (NEVAI)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

"Neurons and blood vessels rely on common guidance signals to wire into elaborate neural and vascular networks that are closely juxtaposed and interdependent: vascular supply of oxygen and nutrients is essential to sustain the high metabolic rate of the nervous system, and conversely neural control of vascular tone is crucial for circulatory homeostasis. However, it remains unclear how the nervous ...
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 2

 TERMINÉ 

Chimeric Antigen Receptors (CARs) for Advanced Therapies (CARAT)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-c ...
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 9

 TERMINÉ 

DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID) (SCIDNET)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for ...
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 13

 TERMINÉ 

IMMUNOMETABOLISM IN HUMAN OBESITY (Fit-The-Fat)

Date du début: 1 sept. 2017, Date de fin: 31 août 2019,

The incidence of obesity and type 2 diabetes (T2D) are inexorably increasing and elevated healthcare costs related to the higher disease-associated morbidity are affecting European and extra-European countries. Obesity is associated with resistance to the action of insulin (called insulin-resistance) in adipocytes, which is thought to be induced by a low-grade inflammation present in the adipose t ...
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 2

 TERMINÉ 

HSC-based therapies for LSDs: understanding the modalities of cell replacement in the LSD brain for improving therapeutic efficacy (HSCSFORLSDBRAIN)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

The recent hypothesis that postnatal microglia are maintained independently of circulating monocytes by local precursors that colonize the brain before birth has relevant implications for the treatment of various neurological diseases, including lysosomal storage disorders (LSDs). LSDs are fatal diseases of childhood occurring in 1:5000-7000 live births; in >50% of the cases, LSD patients experien ...
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 2

 TERMINÉ 

New experimental therapeutic approaches for Parkinson’s disease by direct DA neuronal reprogramming (REPROPARK)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

Neurodegenerative diseases cause a significant burden on the elderly population in Europe. Parkinson’s disease (PD) affects 1.2 million people in Europe and with the increasing life expectancy this number will rise, putting more pressure on health care. Treatment of PD is only symptomatic, and therefore, there is an urgent need for more efficient therapies. Degeneration of mesencephalic DA neurons ...
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 2

 TERMINÉ 

Personal Assistant for healthy Lifestyle (PAL) (PAL)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

Type 1 Diabetes Mellitus (T1DM) portraits a high need and challenge for self-management by young patients: a complex illness with a high and increasing prevalence, a regimen that needs adaptation to patient’s condition and activities, and serious risks for complications and reduced life expectations. When patients do not acquire the knowledge, skills and habits to adhere to their diabetes regimen ...
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 12

 TERMINÉ 

Intelligent Sensor Enabled Eyewear (I-SEE)

Date du début: 1 juil. 2016, Date de fin: 30 sept. 2018,

...ne on the B2C consumer market, as well as the distinctive capabilities of the consortium partners in the electronics (SIGMA), SW (ALTEN), professional service (EY) and scientific (Fondazione Centro San Raffaele) fields, who will strengthen their B2B offer and positioning in the manufacturing industries impacted by the wearable trend. The project ambition is to launch the I-See product line in two ...
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 5

 TERMINÉ 

Treating stroke with Affibody molecules targeting the inflammatory mediator HMGB1 (COUNTERSTROKE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 perso ...
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 6

 TERMINÉ 

AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe (AEGLE)

Date du début: 1 mars 2015, Date de fin: 31 août 2018,

The data generated in the health domain is coming from heterogeneous, multi-modal, multi-lingual, dynamic and fast evolving medical technologies. Today we are found in a big health landscape characterized by large volume, versatility and velocity (3Vs) which has led to the evolution of the informatics in the big biodata domain. AEGLE project will build an innovative ICT solution addressing the who ...
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 14

 TERMINÉ 

PRIvacy and Security MAintaining services in the CLOUD (PRISMACLOUD)

Date du début: 1 févr. 2015, Date de fin: 31 juil. 2018,

With a current volume of over USD 100 billion and annual growth rates of over 10%, the world-wide market for cloud computing can be considered as the major growth area in ICT. However, big companies and public authorities are reluctant to entrust their most sensitive data to external parties for storage and processing. The reason for their hesitation is clear: There exist no satisfactory approache ...
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 17

 TERMINÉ 

Social innovation and light electric vehicle revolution on streets and ambient (Silver Stream)

Date du début: 1 juin 2015, Date de fin: 31 mai 2018,

The SilverStream project addresses the challenges associated with sustainable and affordable personal mobility for the growing and ageing population in congested European cities. The project combines both ergonomic concepts conceived for elderly people and advanced automotive technologies that are quiet, clean, energy efficient and safe. The particular objectives of SilverStream are: i) specificat ...
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 10

 TERMINÉ 

Online Privacy Enforcement, Rights Assurance and Optimization (OPERANDO)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

The goal of the OPERANDO project is to specify, implement, field-test, validate and exploit an innovative privacy enforcement platform that will enable the Privacy as a Service (PaS) business paradigm and the market for online privacy services.The OPERANDO project will integrate and extend the state of the art to create a platform that will used by independent Privacy Service Providers (PSPs) to p ...
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 9

 TERMINÉ 

Investigation of the role of CYLD in Chronic Lymphocytic Leukaemia (CIRCLE)

Date du début: 15 avr. 2016, Date de fin: 14 avr. 2018,

This project will investigate the role of CYLD in Chronic Lymphocytic Leukaemia (CLL). CYLD is a deubiquinating enzyme acting as a tumour suppressor in numerous tumours. CLL is characterized by the accumulation of B-lymphocytes. It affects mostly the elder and has a high incidence rate in Europe. Recent data from CYLD knockout murine models indicate a link between CYLD and CLL, however the approac ...
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 1

 TERMINÉ 

empoWering prIvacy and securiTy in non-trusteD envirOnMents (WITDOM)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,

The advent of the Future Internet prompts fundamental transformations in whole ICT ecosystems, while bringing new opportunities to stakeholders in the availability and rational use of physical resources with large-scale savings in IT investments. It will also pose new security challenges especially for ensuring robust protection of privacy and integrity of personal information, which are a fundame ...
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 7

 TERMINÉ 

Trusted Apps for open CPS (TAPPS)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,

Open and smart cyber-physical systems (CPS) are considered to be the next revolution in ICT with enormous economic potential enabling novel business models for integrated services and products. In many areas of CPS devices, there is a strong trend towards open systems, which can be extended during operation instantly adding functionalities on demand. The main goal of the TAPPS (Trusted Apps for op ...
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 9

 TERMINÉ 

Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative (FRAILOMIC)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a condition named frailty that encompasses changes associated with ageing, life styles and chronic diseases. To detect and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. ...
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 29

 TERMINÉ 

Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials ...
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 16

 TERMINÉ 

A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation (THE ONE STUDY)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2017,

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or ...
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 16

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2016, Date de fin: 30 sept. 2017,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

In vivo dynamics of antibody responses to lymph-borne viruses (IVM-VIRUS-NAB)

Date du début: 1 févr. 2012, Date de fin: 30 juin 2017,

Objective. Our objective is to elucidate how neutralizing antibody (nAb) responses against live viruses are generated in vivo within lymph nodes (LNs). To this end we will make use of state-of-the-art imaging technology (i.e. multiphoton intravital microscopy [MP-IVM]), fluorescent replication-competent viruses and dedicated mouse models.Background/Rationale. nAbs are critical for virus control, p ...
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 1

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

 TERMINÉ 

INternational VEnue for poSTgraduate education (INVEST)

Date du début: 1 nov. 2011, Date de fin: 30 avr. 2017,

The Università Vita-Salute San Raffaele (USR) is a vibrant and acclaimed private University in Milan, Italy, registered by the Italian Ministry of Research. Together with the San Raffaele Research Institute and the San Raffaele Hospital, both controlled by the San Raffaele Foundation hereafter referred to as HSR, it is part of the San Raffaele Biomedical Science Park, hereafter referred to as SRBS ...
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 1

 TERMINÉ 

Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy (INSERT)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in ...
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 10

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

 TERMINÉ 

Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders (TARGETBRAIN)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain re ...
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 10

 TERMINÉ 

Towards clinical translation of new gene targeting technologies for correcting inherited mutations and empowering adoptive immunotherapy of cancer (SUPERSIST)

Date du début: 1 mai 2013, Date de fin: 31 oct. 2016,

Substantial evidence supports the therapeutic potential of ex vivo gene therapy based on Hematopoietic Stem Cell (HSC) or T lymphocytes to treat inherited diseases or cancer. Yet, the intrinsic limitations of current gene replacement approaches based on semi-randomly integrating vectors, and the occurrence in some clinical trials of severe adverse events related to gene transfer, prevent safe depl ...
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 5

 TERMINÉ 

eWall for Active Long Living (eWALL)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

Description eWALL will be an affordable, easy-to-install prefabricated wall that can be mounted on an existing wall and includes all the ICT needed to enable a number of services for the senior citizen to cover major challenges in Active and Healthy Ageing. The project will carry out high-risk and multi-disciplinary research and will have a ...
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 14

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2015, Date de fin: 30 sept. 2016,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES (PROPANE STUDY)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on t ...
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 9