5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis (HLA-DR15 in MS)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,
Multiple sclerosis (MS) is a prototypic CD4+ T cell-mediated autoimmune disease that damages the central nervous system. MS affects young adults and women twice as often as men. Neurological deficits cause substantial disability at an early age with high socioeconomic impact.Both a complex genetic trait and environmental factors are involved in MS etiology. Similar to other autoimmune diseases it ...
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2
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TERMINÉ
Systems Biology of T-cell Activation in Health and Disease (SYBILLA)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. ...
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22
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TERMINÉ
PROteomics SPECification in Time and Space (PROSPECTS)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,
"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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11
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TERMINÉ
"Systems-Level, Multi-layer Understanding of Cellular Responses to Ionizing Radiation" (TRIREME)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
"The TRIREME project aims at developing and implementing a multidisciplinary strategy for a systems-level analysis of a cornerstone of cellular homeostasis – the DNA damage response (DDR). The DDR is a complex signaling network that is responsible for maintaining the stability and integrity of the cellular genome in the face of DNA damage. DDR defects underlie acute and chronic forms of human ailm ...
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6
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TERMINÉ
Analysis of the kinetochore architecture and dynamics using a mass spectrometry based integrative structural approach (Kinetochore Map)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,
A mechanistic understanding of a living cell requires the characterization of the architecture and dynamic assembly of its macromolecular complexes. The proposed project describes a novel integrative approach to determine the topology of protein networks and higher order assemblies using chemical crosslinking, state of the art mass spectrometry (MS) and cryo-electron tomography (cryo-ET). This MS ...
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