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"Investigation of the O2-dependent function of HELZ, an RNA helicase interacting with the oxygen-sensing prolyl-4-hydroxylase PHD2" (HYDRELZ)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2011,
"A crucial step in the adaptation of mammalian cells to oxygen deficiency is the transcriptional activation of hypoxia-inducible genes. Hypoxia-inducible transcription factors (HIFs) are master regulators for the up-regulation of these genes under physiological as well as pathophysiological conditions, such as tumor development and metastasis, cardiovascular diseases and inflammation. HIFs are O2- ...
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