8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Heart OMics in AGEing (HOMAGE)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2019,
As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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22
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TERMINÉ
Radical Medicine: Redefining Oxidative Stress (RADMED)
Date du début: 1 août 2012, Date de fin: 31 juil. 2018,
...vivo/molecular imaging) before the onset of symptoms; and to a new generation of more effective, predictable, and mechanism-based drugs. We also expect to later apply our findings and tools to neurobiology and oncology, where ROS also play physiological and pathological roles.
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1
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TERMINÉ
RNA-based regulation of signal transduction – Regulation of calcineurin/NFAT signaling by microRNA-based mechanisms (CALMIRS)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
"Heart failure is a serious clinical disorder that represents the primary cause of hospitalization and death in Europe and the United States. There is a dire need for new paradigms and therapeutic approaches for treatment of this devastating disease. The heart responds to mechanical load and various extracellular stimuli by hypertrophic growth and sustained pathological hypertrophy is a major clin ...
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1
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TERMINÉ
Targeting cardiac fibrosis for heart failure treatment (FIBRO-TARGETS)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
...argets” for myocardial interstitial fibrosis (MIF) in heart failure. The project is based on the hypothesis that the intervention on novel fibrosis-related targets involved in the processes of fibroblast differentiation to myofibroblasts, the predominance of collagen synthesis over degradation and/or collagen maturation may allow for interstitial repair, thus providing a new strategy for the preve ...
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11
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TERMINÉ
RADical reduction of OXidative stress in cardiovascular diseases (RADOX)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
Cardiovascular disease (CVD) constitutes a major and increasing health burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years. Therefore, the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is an important molecular contributor to the pathogenesis of CVD. However, ox ...
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10
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TERMINÉ
Free Radical Pharmacology: Generators, Targets and Therapeutic Implications (RADICAL PHARMACOLOGY)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
Personalised Medicine is the next revolution in medicine. It is anticipated that we will see a dramatic shift towards predictive diagnostics and mechanism-based, individualised therapies. Cardiovascular diseases (CVD) are the leading causes of death and disability and in Europe cause over 4.3 million deaths (48%) per annum. Since the mechanisms of CVD are not understood, the majority of current th ...
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1
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TERMINÉ
Micro- and Macrocirculation Coupling: a cross sectional investigation of the cross-talk between the two circuits in insulin resistance states (MMC)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,
"Background: The human micro- and macrocirculation have distinct vital roles in the homeostasis of the cardiovascular system. There is a cross-talk between the two circuits to achieve the adequate vascular adaptations. Reciprocal transduction of ills signal between the micro- and macrocirculation may impair their optimal coupling and further accelerate vascular disease. In Europe the prevalence of ...
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1
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TERMINÉ
The mechanisms of cardiovascular risks after low radiation doses (CARDIORISK)
Date du début: 1 févr. 2008, Date de fin: 30 juin 2011,
"Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular dis ...
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