9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
To Notch up a broken heart (StressFate)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
Heart failure is a major health issue and a cause of death and disability. The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration. To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited succ ...
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1
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TERMINÉ
A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol (RESOLVE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CV ...
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14
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TERMINÉ
Engineering protein switches: sensors and regulators for biology and diagnostics (SwitchProteinSwitch)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
... specific application areas, modeling tools will be developed that allow quantitative analysis and prediction of conformational stabilities for modular protein switches. The availability of these robust and generally applicable engineering strategies will proof beneficial to many areas of life sciences, providing essential tools for intracellular imaging, synthetic biology, and molecular diagnosti ...
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1
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TERMINÉ
Next-generation integrated MNBS-platform for instant diagnostics with single-molecule resolution (NextDx)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,
A spearhead function that lies within the promise of MNBS technologies is the rapid and sensitive detection of biomarker molecules in raw biological samples. However, it has been very difficult to realize the promise due to two key challenges:the signal-over-background challenge, i.e. many biomarkers have very low concentrations and real-life biological samples generate very high background signal ...
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7
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TERMINÉ
Functional prognosis simulation of patient-specific spinal treatment for clinical use (MySPINE)
Date du début: 1 mars 2011, Date de fin: 31 août 2014,
Description
Improving the treatment of lower back painThe MySpine project aims to improve the treatment of lower back pain. Nowadays treatment and prognosis of spinal disc degeneration are still based on trial and error decisions from the surgeon, leading to numerous post treatment complications and eventual morbidity. MySpine is working ...
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9
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TERMINÉ
Using chemical-biology to synthesis and study nuclear receptor proteins (CHEMbioNMR)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,
...synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with paras ...
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1
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TERMINÉ
Disc-degeneration linked pathologies: novel biomarkers and diagnostics for targeting treatment and repair (Genodisc)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2013,
Disorders arising from degeneration of the intervertebral disc are an enormous clinical and financial burden on European societies. Most of the burden arises from 10% of patients who become chronically disabled. Any factor which will improve treatment of back pain sufferers or prevent development of chronic disability would have an important impact both on society and in improving quality of life ...
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10
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TERMINÉ
Osteoporotic Virtual Physiological Human (VPHOP)
Date du début: 1 sept. 2008, Date de fin: 31 oct. 2012,
...entional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the absolute risk of bone fracture will be much more accurate than any predic ...
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21
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TERMINÉ
Image-controlled Ultrasound-induced Drug Delivery (SonoDrugs)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,
The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urg ...
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