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Plus de 40 projets européens trouvés

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 TERMINÉ 

Cellular Hypoxia Alters DNA MEthylation through Loss of Epigenome OxidatioN (CHAMELEON)

Date du début: 1 sept. 2014, Date de fin: 31 août 2019,

"DNA methylation was originally described in the 1970s as an epigenetic mark involved in transcriptional silencing, but the existence of DNA demethylation and the enzymes involved in this process were only recently discovered. In particular, it was established that TET hydroxylases catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxyg ...
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 1

 TERMINÉ 

From zebrafish to man Modifying amyotrophic lateral sclerosis (ALS): translation of biology into therapy (ModifALS)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neurons. As for other neurodegenerative disorders, translation of newly acquired biological insights into therapies has been difficult. In the current project we intend to contribute to the development of therapeutic approaches for ALS. We want to generate novel models, identify new therapeutic targets for interv ...
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 1

 TERMINÉ 

Aberrant RNA degradation in T-cell leukemia (ART)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"The deregulation of transcription is an important driver of leukemia development. Typically, transcription in leukemia cells is altered by the ectopic expression of transcription factors, by modulation of signaling pathways or by epigenetic changes. In addition to these factors that affect the production of RNAs, also changes in the processing of RNA (its splicing, transport and decay) may contri ...
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 1

 TERMINÉ 

Function of Chemosensory Circuits (CHEMOSENSORYCIRCUITS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

Smell and taste are the least studied of all senses. Very little is known about chemosensory information processing beyond the level of receptor neurons. Every morning we enjoy our coffee thanks to our brains ability to combine and process multiple sensory modalities. Meanwhile, we can still review a document on our desk by adjusting the weights of numerous sensory inputs that constantly bombard o ...
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 2

 TERMINÉ 

Exploring the targeted delivery of biopharmaceuticals enabled by glycosylation control (GlycoTarget)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Most biotechnological therapeutics used in the clinic today and under current development, are of protein nature. Eukaryotic expression systems (such as yeasts and mammalian cells) for these therapeutic proteins add carbohydrate moieties (glycans) to the proteins, and these glycans strongly modulate the protein's in vivo biodistribution and therapeutic efficacy. Until recently, no adequate tools w ...
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 1

 TERMINÉ 

Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokine-based therapies (CYRE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. I ...
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 1

 TERMINÉ 

Atlas of leaf growth regulatory networks in MAIZE (AMAIZE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Understanding how organisms regulate size is one of the most fascinating open questions in biology. The aim of the AMAIZE project is to unravel how growth of maize leaves is controlled. Maize leaf development offers great opportunities to study the dynamics of growth regulatory networks, essentially because leaf development is a linear system with cell division at the leaf basis followed by cell ...
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 1

 TERMINÉ 

Ribosome defects in cancer (RIBOCANCER)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

...ell leukemia (T-ALL) harbor acquired mutations in the ribosome, the cellular protein translation factory. We found mutations in RPL10, RPL5 and RPL22, 3 proteins of the large 60S ribosomal subunit. Strikingly, 6.5% of T-ALL patients had the same RPL10 R98S missense mutation. Although congenital ribosome defects were previously linked to higher cancer risk, the concept that defects in the ribosome ...
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 2

 TERMINÉ 

Functional Analysis of Dopamine Prediction Error Circuits (DopaPredict)

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2018,

One of the key goals in neuroscience is to understand how neural activity generates behavior. Electrophysiological recordings have provided great insights into this relationship, but they cannot resolve the contribution of specific neuronal cell types. Moreover, it has been notoriously difficult to move beyond correlation and demonstrate the functional significance of neural firing for specific be ...
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 1

 TERMINÉ 

Metagenomics in Cardiometabolic Diseases (METACARDIS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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 18

 TERMINÉ 

The importance of gene and genome duplications for natural and artificial organism populations (DOUBLE-UP)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The long-term establishment of ancient organisms that have undergone whole genome duplications has been exceedingly rare. On the other hand, tens of thousands of now-living species are polyploid and contain multiple copies of their genome. The paucity of ancient genome duplications and the existence of so many species that are currently polyploid provide an interesting and fascinating enigma. A q ...
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 1

 TERMINÉ 

Dissecting the retinal inputs to behaviorally relevant computations in the central brain (VisualCircuits)

Date du début: 1 juin 2014, Date de fin: 31 mai 2018,

A key function of the visual system is to extract behaviourally relevant features about the visual scene from the barrage ofincoming photons. This process begins in the retina, a powerful image processer that recent studies have revealedseparates the incoming information into ~20 distinct neural representations. Within central visual brain regions specificdetails of the visual scene are often neat ...
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 1

 TERMINÉ 

Uncovering the role of new synaptic adhesion molecules in encoding synaptic connectivity in the brain (SynapseCode)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

Synapses connect neurons into a network that encodes our thoughts, memories and personalities. Loss of synaptic connectivity is thought to underlie a variety of cognitive disorders such as autism, schizophrenia and Alzheimer’s disease, but little is known about the molecules and mechanisms that establish and maintain the precise patterns of synaptic connectivity in the brain. Neither is it underst ...
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 1

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Control mechanisms that pattern microtubules for switching cell division planes during plant morphogenesis (DIVISIONPLANESWITCH)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Oriented cell divisions dictate morphogenesis by shaping tissues and organs of multicellular organisms. Oriented cell divisions have profound influence in plants because their cell positions are locked by shared cell walls. A relay of cell divisions involving precise division plane switches determines embryonic body plan, organ layout and organ architecture in plants. Cell division planes in plant ...
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 1

 TERMINÉ 

Oxygen sensing in macrophages: implications for cancer and ischemia (OxyMO)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Macrophages exist in distinct differentiation states. Proangiogenic/immunosuppressive (M2-like) macrophages and antitumoral/proinflammatory (M1-like) macrophages represent two extremities of a continuum. Because lineage-defined subsets have not been identified yet, macrophage heterogeneity is likely to reflect the plasticity of these cells in response to microenvironmental signals. The concept tha ...
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 1

 TERMINÉ 

Universal Flu Vaccine (UNIVACFLU)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Currently licensed influenza vaccines promote an effective antibody response, but only against influenza virus strains that antigenically match the vaccine composition. Little protection is induced by these vaccines against antigenically drifted strains such as those emerging from an avian or swine reservoir. Hence there is a great need to develop broadly cross-reactive flu-vaccines.The aim is to ...
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 8

 TERMINÉ 

The role of loss-of-heterozygosity in cancer development and progression (DelCancer)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Somatically acquired loss-of-heterozygosity (LOH) is extremely common in cancer; deletions of recessive cancer genes, miRNAs, and regulatory elements, can confer selective growth advantage, whereas deletions over fragile sites are thought to reflect an increased local rate of DNA breakage. However, most LOHs in cancer genomes remain unexplained. Here we plan to combine a TALEN technology and the e ...
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 1

 TERMINÉ 

Chromatin in Plants – European Training and Mobility (CHIP-ET)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"The Research Training Network CHIP-ET will focus on the study of protein complexes that modulate chromatin structure to activate RNA polymerase II–mediated transcription. Research will address how developmental and environmental stimuli such as light and circadian rhythm signal to these complexes to modulate transcription. The interactome of the complexes will be determined, as well as their geno ...
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 6

 TERMINÉ 

InFLUenza virus UNIVersal VACcine development program (FLUNIVAC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Effectively protecting the general population from seasonal and pandemic influenza has proven to be a challenge, since influenza viruses continue to escape from and evade immunity. Current influenza vaccines fail to provide long-lasting and broad protection against multiple strains of influenza. For the development of a universal influenza vaccine, we have to “do better than Nature”, since even na ...
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 8

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Reverse engineering of vascular patterning through mosaic in vivo analysis of endothelial cell shape regulation (REshape)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Current angiogenesis research using genetic loss-of function approaches in mouse and zebrafish models provides for a growing number of genes implicated in blood vessel formation. Mechanistic insight often remains unsatisfactory as phenotypes fall into common categories. Our recent cell competition models combined with computational analysis have transformed the way we can study mechanisms in vascu ...
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 1

 TERMINÉ 

A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities (TriForC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still under ...
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 11

 TERMINÉ 

Can metabolic states induced by diabetes and obesity promote cancer? (MetabolismConnect)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Continuous research on cancer has unraveled genetic alterations and subsequently signal transduction pathways changed in a cancer cell, thereby it emerged that many of the genetic factors commonly altered in cancer cells often target metabolic genes. An altered metabolism allows cancer cells to sustain their proliferative needs. Yet, whether altered metabolic fluxes and metabolite concentrations, ...
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 1

 TERMINÉ 

VIB International Postdoctoral Program to boost '-omics' technologies throughout the institute (OMICS@VIB)

Date du début: 15 déc. 2011, Date de fin: 14 juin 2017,

"VIB is a life science centre of excellence in Flanders (Belgium) established in 1996. We have gained valuable experience in selecting, training and employing young researchers, amongst others thanks to our International Ph.D. Program. Only 5 years after the start of this program, VIB’s student population has grown from 275 Belgian students into a dynamic community of nearly 400 students, represen ...
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 1

 TERMINÉ 

Co-morbidity in relation to Aids (COBRA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, de ...
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 12

 TERMINÉ 

POLARITY AND SUBCELLULAR DYNAMICS IN PLANTS (PSDP)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

"Plant life strategy is marked by acquisition of highly flexible development that adapts plants’ phenotype to the environment. Various environmental signals are integrated into the endogenous signalling networks involving the versatile phytohormone auxin. The intercellular auxin transport mediates a large variety of adaptive plant growth responses. Subcellular polar distribution of PIN auxin trans ...
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 2

 TERMINÉ 

Signaling and activation pathways of the NOD-like receptors Ipaf, Nlrp1b and Nlrp12 (SigNLRact)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

My overall aim is to define the role of NOD-like receptors (NLRs) in immunity and to understand the importance of their signaling networks in health and disease.NLR family members are thought to sense pathogens and endogenous alarmins in intracellular compartments to trigger innate immune responses. Recent progress was made in mapping the signaling pathways of the NLRs Nod1, Nod2 and Nlrp3, but th ...
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 1

 TERMINÉ 

Molecular characterization of environmental stress responses in the marine diatom Phaeodactylum tricornutum (UVTRANCYCLUM)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2016,

Solar UV-B radiations can have a negative impact on photosynthetic organisms leading to a reduction of the uptake of atmospheric carbon dioxide. Aquatic ecosystems absorb a similar amount of atmospheric carbon dioxide as terrestrial ecosystems, are estimated to produce half of the biomass on our planet and are a major source for human food supply. At the base of these ecosystems, phytoplankton are ...
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 1

 TERMINÉ 

SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING (AGEDBRAINSYSBIO)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at le ...
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 15

 TERMINÉ 

Molecular Studies of Astrocyte Function in Health and Disease (AstroFunc)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

Brain consists of two basic cell types – neurons and glia. However, the study of glia in brain function has traditionally been neglected in favor of their more “illustrious” counter-parts – neurons that are classed as the computational units of the brain. Glia have usually been classed as “brain glue” - a supportive matrix on which neurons grow and function. However, recent evidence suggests that ...
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 1

 TERMINÉ 

Training network for next generation vaccinologists (VACTRAIN)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Vaccines are the most cost-effective health interventions available (WHO). The impact of vaccination on the health of the world’s population cannot be overstressed. Vaccinolgy is the multidisciplinary discipline of developing vaccine interventions it combines knowledge from basic sciences, medical sciences, public health and social sciences. Ideally a vaccinologists would be able to have a general ...
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 9

 TERMINÉ 

DISSECTING THE ROLE OF HIF-PROLYL-HYDROXYLASE 2 (PHD2) IN BREAST CANCER METASTASIS – IDENTIFYING NOVEL THERAPEUTIC TARGETS (PHD2 in metastasis)

Date du début: 1 juil. 2014, Date de fin: 13 oct. 2016,

Breast cancer (BC) is the most frequently diagnosed cancer in women, affecting one in eight women. Despite improved treatment strategies, BC recurrence after initial therapy is still responsible for nearly 500,000 deaths worldwide each year. This is related to the fact that BC cells metastasize very early in the disease course, and often remain unnoticed at the time of diagnosis. Novel therapeutic ...
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 1

 TERMINÉ 

The development and evaluation of Multipurpose crops as new biorefining feedstocks for the production of industrial BioProducts and biomass (MultiBioPro)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

The overall strategic objective of MultiBioPro is to exploit natural resources from genetic varieties of two industry-utilized plant species, poplar and the tobacco tree Nicotiana glauca, for direct applicability to novel industrial end products. The consortium will explore already existing poplar and N. glauca genotypes in parallel with innovative state-of-the-art translational research from the ...
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 12

 TERMINÉ 

The impact of asthma on dendritic cell development; analysis at the cellular and the molecular level (DC IN ASTHMA)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,

Allergic asthma is a chronic inflammatory disease of the airways and a worldwide problem. Dendritic cells (DC) have a key role in the development of this disease, making them interesting targets for therapy. Novel asthma therapies could involve interference with the development and relative abundance of functionally specialized lung DC subsets. Allergen exposure drastically changes airway DC subse ...
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 1

 TERMINÉ 

High throughput analysis of the in vivo metabolite/protein interactome in plants (TAPMIN)

Date du début: 1 juin 2014, Date de fin: 31 mai 2016,

In the last decade, new technologies have emerged to study protein-protein and protein-nucleic acid interactions under near-physiological conditions at large scale. In contrast, development of similar performing technologies for screening and discovery of in vivo metabolite/protein interactions has received little attention. Nonetheless, metabolites comprise a large and important fraction of the c ...
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 1

 TERMINÉ 

Role of microRNA dysregulation in Alzheimers Disease (MIRNA_AD)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,

Alzheimer's Disease (AD) is a major health problem in aging societies. Remarkable progress in the study of the rare genetic forms of the disease has lead to the identification of several key players like APP and the secretases, but the molecular basis of sporadic AD remains largely unresolved. The convergence of several factors (multicausality) has to be considered. miRNAs are crucially involved i ...
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 1

 TERMINÉ 

Cellular Hypoxia Alters DNA Methylation through Loss of Epigenome Oxidation (CHAMELEO)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2016,

"DNA methylation is integral to the regulation of gene transcription but is deregulated in cancer. Mechanisms causing this dysregulation are however poorly understood. Although DNA methylation mechanisms were described for several decades ago, the enzymes responsible for DNA demethylation were only discovered a few years ago: TET enzymes catalyze the conversion of 5-methylcytosine to 5-hydroxymeth ...
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 1

 TERMINÉ 

Targeting endothelial metabolism: a novel anti-angiogenic therapy (ECMETABOLISM)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,

Current anti-angiogenesis based anti-tumor therapy relies on starving tumors by blocking their vascular supply via inhibition of growth factors. However, limitations such as resistance and toxicity, mandate conceptually distinct approaches. We will explore an entirely novel and long-overlooked strategy to discover additional anti-angiogenic candidates, based on the following innovative concept: ¿r ...
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 1

 TERMINÉ 

Immunogenomics: Mouse to Human Translational Research (IMMUNO)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

Control over the activation of the immune system is central to the key issues of human health. Autoimmunity, atopy, persistent infections and tumours all share a common root cause in a sub-optimal balance between immune activity and tolerance. At the heart of this balance are T cells, with the capacity for both activation and suppression. Research in mouse models has allowed enormous progress to b ...
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 1