20 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Mechanotransduction in Cell-to-Cell Communication (MechComm)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
Cell-to-cell communication pathways coordinate cellular functions in multicellular organisms. Cells that are nearest neighbours can communicate through specific interactions between ligand and receptor proteins present in their respective cell membranes. The objective of this research program is to address the hypothesis that the physical context of the ligand/receptor interaction contributes to d ...
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1
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TERMINÉ
The role of pericytes in central nervous system scarring and fibrosis (PERICYTESCAR)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
"Damage to the central nervous system (CNS) often leads to persistent functional deficits, causinggreat individual suffering and enormous cost to society. The manifestation of these deficits isbelieved to be associated with the scar tissue that forms locally at lesions, causing permanent tissuealteration and blocking regeneration.Research on CNS scar tissue has primarily focused on astrocytes and ...
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1
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TERMINÉ
Irisin - a novel myokine protective against metabolic disease (NOVEL_MYOKINE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Cardiovascular disease and diabetes constitute the major disease burden in the western world with growing morbidity. Exercise is known to ameliorate many of the key processes in the pathogenesis of these diseases, but the underlying mechanism is not clear. Especially little is known about how exercise affects non-muscle tissues such as the heart, fat and liver. Knowledge of such pathways could lea ...
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1
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TERMINÉ
Adipose tissue mass regulation in lean and obese individuals (HUFATREG)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. In humans the generation of fat cells (adipocytes) is a major factor behind the growth of adipose tissue during childhood. The factors determining the fat mass in adults, however, are not fully understood. Increased fat storage in fully differentiated adipocytes, res ...
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1
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TERMINÉ
NOVEL STRATEGIES FOR BRAIN REGENERATION (BRAINGAIN)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
"In contrast to mammals, newts possess exceptional capacities among vertebrates to rebuild complex structures, such as the brain. Our goal is to bridge the gap in the regenerative outcomes between newts and mammals. My group has made significant contributions towards this goal. We created a novel experimental system, which recapitulates central features of Parkinson’s disease in newts, and provide ...
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1
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TERMINÉ
Neurogenesis in the adult human brain (Neural renewal)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
One of the characteristics of the central nervous system is its plasticity, with for example a remarkable capacity to store new information. It was for long time thought that there was very little plasticity in terms of exchanging cells and that we essentially were limited to the neurons we were born with. It is now well established that new neurons are added to certain regions of the adult brain ...
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1
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TERMINÉ
The Physiological Control of Stem Cells: Obesity, Insulin, and Neural Stem Cell Dynamics (ObInNSC1)
Date du début: 1 juil. 2013, Date de fin: 5 oct. 2015,
Stem cells are essential to the homeostasis, repair, and function of the tissues in which they reside. Stem cells can be regulated by systemic endocrine signals, meaning environmental factors that impact physiological state, such as diet, infection, and societal stress, can greatly impact stem cell function. Neural stem cells (NSCs) in the hippocampus divide to generate new neurons in the adult, a ...
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1
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TERMINÉ
TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases (TREATPOLYQ)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,
Protein aggregation is a hallmark of many late onset neurodegenerative disorders including Parkinson’s Disease (PD), Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), prion diseases as well as the group of polyglutamine diseases (polyQ). The aim of this proposal is to create a network of European partners bridging important basic mechanisms involved in proteinopathies, research of mod ...
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17
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TERMINÉ
Single-cell Gene Regulation in Differentiation and Pluripotency (Single-cell Genomics)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2015,
We aim to study transcriptomes with single-cell resolution, a long-standing goal in biology, to answer fundamental questions about gene regulation. The main objective concerns gene regulation during in vivo differentiation and in pluripotent cells by studying single-cells from murine preimplantation embryos, a model system with natural single-cell resolution, important biology and medical potentia ...
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1
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TERMINÉ
Metastatic tumours facilitated by hypoxic tumour micro-environments (METOXIA)
Date du début: 1 févr. 2009, Date de fin: 31 juil. 2014,
"Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing the potential of a successful treatment of the cancer patient. This project seeks to clarify the roles and functions of the ...
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21
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TERMINÉ
"The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds" (SYSTEQ)
Date du début: 1 févr. 2009, Date de fin: 30 nov. 2013,
"Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture tox ...
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6
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TERMINÉ
Genomic stability -chromosome segregation and repair (GENOMIC STABILITY)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
The eukaryotic genome combines a highly dynamic nature with stable transmission of genetic information from mother to daughter cells. This is achieved by a plethora of protein networks regulating processes such as chromosome duplication, segregation and repair. The principal aim of our research is to determine the molecular interplay between chromosome segregation and repair. Accurate execution of ...
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1
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TERMINÉ
European Consortium for Stem Cell Therapy for Neurodegenerative Diseases (NEuroStemCell)
Date du début: 1 déc. 2008, Date de fin: 31 mai 2013,
The NEuroStemCell consortium will foster collaboration between leading European experimental and clinical researchers in order to maximise the prospects for successful clinical trials of stem cell therapy for Parkinson's (PD) and Huntington's (HD) Disease. The activities will be driven by a Clinical WorkPackage (WP), which will set the requirements, and monitor and guide advances in development of ...
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15
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TERMINÉ
Developmental Transcription Factors in Dopamine Neuron Maintenance (Dopamine Neuron Code)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2012,
Understanding mechanisms underlying the generation of diverse neuronal subtypes is one of the major challenges in current neuroscience research. Our interest is focused on midbrain dopamine (mdDA) neurons. These cells are essential for the control of multiple brain functions, including movement, emotion and reward, and dysfunction is involved in the pathogenesis of several mental and neurological ...
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1
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TERMINÉ
Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes (INFRAFRONTIER)
Date du début: 1 mars 2008, Date de fin: 31 déc. 2012,
Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ...
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29
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TERMINÉ
NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY (NotchIT)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with path ...
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11
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TERMINÉ
Servicing the European Biomedical Research Community: Archiving and Dissemination of Mouse Models of Human Disease (EMMAservice)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:1) Develop a series of mutant alleles for every gene in the mouse genome2) Determine the phenotypic consequences of each mutation3) Identify mouse models for the complete d ...
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11
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TERMINÉ
Comparative epidemiology of genetic lineages of Trypanosoma cruzi (ChagasEpiNet)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
The focus of this multidisciplinary proposal is to elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. The project will unite skills in genotyping, genomics, genetics and pathogenesis in Europe with considerable compatible skills in South America, and with key research in endemic areas that have distinct characteristics. The ...
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15
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TERMINÉ
European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)
Date du début: 1 mars 2008, Date de fin: 31 août 2012,
EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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25
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TERMINÉ
Molecular coding and subset specification of dopamine neurons generating the the meso-limbic and nigro-striatal system (mdDANEURODEV)
Date du début: 1 janv. 2009, Date de fin: 31 mars 2012,
This project aims to elucidate the molecular coding of meso-diencephalic dopaminergic (mdDA) neurons forming the complex meso-limbic and nigro-striatal dopaminergic system in the vertebrate central nervous system. Recent advances in molecular and developmental biology have shown that this system harbors u multitude of functional units that are defined by spatial and temporal cues and are represen ...
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