4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2020,
Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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13
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TERMINÉ
Configurable and Adaptable Trucks and Trailers for Optimal Transport Efficiency (TRANSFORMERS)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Today trucks are designed and optimised towards a limited variance set of usage and for maximum payload. Future trucks-trailers are easily adaptable for each freight, load and mission. And, in the operation phase, the vehicle combination automatically adjusts itself to the actual driving environment (i.e. traffic situation, topology, and payload). This option has large potential to contribute to t ...
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14
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TERMINÉ
OPTImization of the automated Fitting to Outcomes eXpert with language-independent hearing-in-noise test battery and electro-acoustical test box for cochlear implant users (OPTI-FOX)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2012,
"Patients suffering from sensori-neural hearing loss caused by damaged hair cells in the cochlea and diagnosed as being profoundly deaf, are potential candidates for cochlear implantation. Today, there are a number of important limitations with respect to the optimal use of these devices in deaf patients. Firstly, cochlear implant speech processors need to be adjusted so that sounds perceived by t ...
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11
Participants partenaires
TERMINÉ
Targeting LRP5 to Increase Bone Formation in Osteoporosis (TALOS)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,
"The balance between bone resorption and bone formation determines the mass and structural integrity of the skeleton and is disturbed in osteoporosis. In contrast to the molecular mechanisms regulating bone resorption, knowledge of the mechanisms regulating bone formation is limited. A recent breakthrough has been the identification of a link between bone mass in humans with rare bone disorders an ...
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