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18 projets européens trouvés

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 TERMINÉ 

A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia (TRIMAGE)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Schizophrenia is a severe mental disorder that manifests early in life and imposes a high social and economic burden on European societies. An imaging tool that enables the diagnosis of schizophrenia during early development is extremely desirable and is requested by the clinical community in order to make the management of the disease more effective.TRIMAGE aims to optimise and validate an integ ...
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 11

 TERMINÉ 

Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation (MagnetoGenetics)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetrat ...
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 2

 TERMINÉ 

Multimodal Imaging of Neurological Disorders (MINDView)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The key concept behind this proposal is the development of a very high resolution and high efficiency brain dedicated Positron Emission Tomograph (PET) imager that can visualize neurotransmitter pathways and their disruptions in the quest to better diagnose and consequently to better treat schizophrenia. In addition, the plan is for this compact PET imager to be integrated with a Magnetic Resonanc ...
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 10

 TERMINÉ 

Multimodal Molecular Imaging (MUMI)

Date du début: 1 juin 2012, Date de fin: 31 mai 2017,

"Imaging has become an integral part of diagnosis and staging of disease. This proposal aims at the development if innovative imaging methods for the visualization and quantitative assessment of biologic processes in-vivo. The simultaneous MR/PET data acquisition will be employed o integrate structural, physiologic and molecular information for the phenotyping of human disease and therapeutic deci ...
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 1

 TERMINÉ 

Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2017,

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
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 9

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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 29

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
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 25

 TERMINÉ 

Semantic Infostructure interlinking an open source Finite Element tool and libraries with a model repository for the multi-scale Modelling and 3d visualization of the inner-ear (SIFEM)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2016,

The clinical evidence indicates that the number of people with all levels of hearing impairment and hearing loss is rising mainly due to a growing global population and longer life expectancies. Hearing loss caused by pathology in the cochlea or the cochlear nerve is classified as sensorineural hearing loss. The study of the normal function and pathology of the inner ear has unique difficulties as ...
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 11

 TERMINÉ 

Building data bridges between biological and medical infrastructures in Europe (BIOMEDBRIDGES)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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 26

 TERMINÉ 

ATMP GMP Open Access Research Alliance - AGORA (AGORA)

Date du début: 1 sept. 2013, Date de fin: 31 oct. 2015,

We propose an academic & industrial partnership to facilitate safe and effective delivery of new advanced therapy medicines within the framework of the relevant EU regulations which our previous FP7 funded project have identified as creating unanticipated barriers to development of this field. Over 80% of advanced therapy medicines (ATMPs) trials in the EU are academic investigator led and sponsor ...
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 8

 TERMINÉ 

Biohybrid templates for peripheral nerve regeneration (Biohybrid)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

The BIOHYBRID consortium was build up with the overall aim to develop, in a preclinical perspective, an innovative biohybrid artificial nerve device for the regenerative treatment of traumatic injuries of peripheral nerves. This consortium consists of three active and well integrated SMEs as well as seven academic partners that are recognised leaders in the scientific areas of interest for this pr ...
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 10

 TERMINÉ 

Understanding chronic pain and improving its treatment (EUROPAIN)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2015,

We will establish an international team of leading researchers and clinicians (EuroPain) to undertake multidisciplinary translational research which will: 1) increase the understanding of chronic pain mechanisms; 2)facilitate the development of novel analgesic drugs; and 3) improve the treatment of chronic pain patients.Nineteen researchers drawn from the London Pain Consortium, the Danish Pain Re ...
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 29

 TERMINÉ 

A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

 TERMINÉ 

Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis (GAMBA)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of ...
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 9

 TERMINÉ 

The impact of Regulation (EC) No 1394/2007 on the development of Advanced Therapy Medicinal Products (ATMPs): an academic perspective (Academic GMP)

Date du début: 1 sept. 2010, Date de fin: 31 mai 2013,

Advanced Therapy Medicinal Products (ATMPs) are medicinal products for human use, based on gene therapy, somatic cell therapy or tissue engineering. A rapidly growing area in translational research, they represent the ‘next generation’ of complex medicines for complex diseases and pose particular challenges to medicines regulation.Regulation (EC) No 1394/2007 has been designed to ensure the free m ...
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 9

 TERMINÉ 

Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease (EVINCI-study)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumora ...
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 22