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 TERMINÉ 

Scaling up Safe Surgery for District and Rural Populations in Africa (SURG-Africa)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

In sub-Saharan Africa 95% of the population has no access to surgical services. In this region surgery – a proven and often life-saving intervention – is only accessible to urban populations, with only one surgeon per 2.5 million people in rural areas. Emerging evidence demonstrates that major surgery can be undertaken safely and effectively at district hospitals, making it accessible to otherwise ...
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 6

 TERMINÉ 

Development and Application of a New Class of Halogenated Reagents to Commercially Valuable Targets (Halo)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

...opean pharmaceutical manufacturing industry as it continues to face increased competition from other economiesIn order to achieve this aim we need to bring together expertise in(i) Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”](ii) Enantioselective fluorination [Nagoya University Japan, “Nagoya”](iii) Drug development and production [Integrated Research in Biotechnology & Medicin ...
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 2

 TERMINÉ 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 TERMINÉ 

Water - Sustainable Point-Of-Use Treatment Technologies (WATERSPOUTT)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment ...
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 18

 TERMINÉ 

Endoplasmic Reticulum Stress in Health and Disease (TRAIN-ERS)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the ...
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 12

 TERMINÉ 

Gender-related differences in expression of microRNAs in cystic fibrosis (GENDER-CF)

Date du début: 1 sept. 2017, Date de fin: 31 août 2019,

...es encoding key inflammatory mediators such as Toll-like receptor 4 (TLR4) and tumour necrosis factor a receptor associated factor-6 (TRAF6). This highly innovative proposal, to be implemented at the Royal College of Surgeons Ireland (RCSI), aims to study the regulation of key miRNAs by estrogen and investigate if this plays a role in the CF gender gap. I will combine my own expertise in pulmonary ...
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 1

 TERMINÉ 

An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts (LAF-GRAFT)

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

...cular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to ...
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 1

 TERMINÉ 

Diabetes Reversing Implants with enhanced Viability and long-term Efficacy (DRIVE)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their po ...
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 14

 TERMINÉ 

Adverse Immune Signatures and their Prevention in Corneal Transplantation (VISICORT)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- an ...
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 12

 TERMINÉ 

Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine (MEL-PLEX)

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2018,

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines ...
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 11

 TERMINÉ 

Gene2Skin - Roadmap for advanced genetic engineering-based skin therapies (Gene2Skin)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,

Skin diseases and disorders are among the most common health problems worldwide and are associated with a considerable burden. It encompasses psychological, social and financial consequences not only on the patients, but also on their families and on society. Chronic and incurable skin diseases/disorders, such as bullous disorders, fibrosis and ulcers, are associated with significant morbidity in ...
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 3

 TERMINÉ 

MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy (EPIMIRNA)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling p ...
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 19

 TERMINÉ 

Development of a chemotherapeutic gel for glioblastoma multiforme treatment (THERAGEL)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Advanced nanotechnology-based materials offer new solutions to the challenges associated with the non-specific delivery of therapeutics that leads to ineffective treatments, especially in oncology. Currently, both therapeutic and diagnostic molecules are administered systemically, increasing the likelihood of unwanted side effects. THERAGEL will develop a novel delivery system that enables selecti ...
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 1

 TERMINÉ 

Sustainable Polypeptide Nanoparticle Platform for Drug Delivery (NanoCap)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Biodegradable and biocompatible nanoparticles have high potential as viable carriers of active compounds in a broad range of applications for example for cosmetic ingredients as well as therapeutically active compounds such as vaccines, genes, drugs and other biomolecules (drug delivery). To advance current polymer nanoparticle technology we propose a novel nanomaterial platform based on synthetic ...
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 1

 TERMINÉ 

Bio-conjugatable and Bio-responsive Near Infrared Fluorochromes (NIR-BIO-FLU)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2018,

Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, th ...
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 1

 TERMINÉ 

Macroporous Polymer Monoliths as a Low-Cost Bioanalytical Platform for Biopharmaceutical Glycoprotein (PoreSelect)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2018,

Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide probl ...
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 2

 TERMINÉ 

SYSTEMS-BASED VIEW OF MELANOMA PROGRESSION: TOWARDS NOVEL DIAGNOSTIC (AND THERAPEUTIC) APPLICATIONS (SYS-MEL)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis a ...
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 7

 TERMINÉ 

Advanced Materials for Cardiac Regeneration (AMCARE) (AMCARE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomat ...
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 10

 TERMINÉ 

WELCOME - Wearable Sensing and Smart Cloud Computing for Integrated Care to COPD Patients with Co-morbidities (WELCOME)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Description Innovative solutions for COPD multi-morbid patients To help Chronic Obstructive Pulmonary Disease (COPD) patients with comorbidities and to reduce the burden on our health systems, the WELCOME project aims to create innovative solutions such as an integrated care management tool and a ...
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 13

 TERMINÉ 

EPISCHOOL – pokonajmy bariery razem!

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2017,

The aim of the Project is to bring up a serious problem - epilepsy among children and teenagers at school. This problem touches not only persons with the disease, but also their teachers who not always are aware of the seriousness of the problem and are competent enough to cope with it. There are many examples of mistreating sick persons, such as forcing them to change school etc. By initializing ...
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 4

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2016, Date de fin: 30 sept. 2017,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn (THE HIP TRIAL)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2017,

Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategie ...
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 17

 TERMINÉ 

Project for higher education student and staff mobility between Programme Countries and Partner Countries

Date du début: 1 févr. 2016, Date de fin: 31 mai 2017,

This is a project for higher education student and staff mobility between Programme Countries and Partner Countries. Please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Project for higher education student and staff mobility between Programme Countries and Partner Countries

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

This is a project for higher education student and staff mobility between Programme Countries and Partner Countries. Please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Organo-Catalytic Nanoparticles for Organic Synthesis (OCN4OS)

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

The objective of this proposal is the development of a platform of recyclable organocatalysts that could be employed in the preparation of drugs or intermediates thereof. In order to achieve this objective the proposal brings together 3 partners with complementary skills: an expert in Phase Transfer Catalysis, Organo-Catalysis and synthesis (RCSI), an expert in development of DNA based catalysis a ...
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 3

 TERMINÉ 

Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing (VascColl)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2017,

...s, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal O’Brien’s group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturatio ...
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 1

 TERMINÉ 

miRNA-activated Scaffold Technologies for Cartilage Regeneration (miRaColl)

Date du début: 1 sept. 2015, Date de fin: 28 févr. 2017,

Adult articular cartilage has a limited capacity for repair so when damaged it can lead to joint degeneration and ultimately osteoarthritis. In our lab we have had significant success in enhancing tissue regeneration by functionalising collagen-based scaffolds for the delivery of therapeutic genes. In this project we propose to apply this concept for the delivery of microRNAs to promote enhanced c ...
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 1

 TERMINÉ 

Protein biomarker for the prediction of response to endocrine treatment in breast cancer patients (EndoPredict)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

Classical pathologic parameters have been used to inform adjuvant clinical treatment choices for early breast cancer patients. There remain a significant number of patients however, who despite a reportedly favourable prognostic profile, experience metastatic disease. Elucidation of the mechanisms of tumour adaptability and the identification of predictive markers of early recurrence is the basis ...
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 2

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2015, Date de fin: 30 sept. 2016,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Clinical Officer Surgical Training in Africa (COST - Africa)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2016,

Obstetrical and abdominal emergencies, and trauma, much of it affecting children, represent a major and neglected part of Africa’s burden of disease. Countries cannot train and retain sufficient specialist surgeons (doctors) to address these priorities. We propose a surgical training intervention targeted at Clinical officers (COs), who are trained non-physician clinicians that form the backbone o ...
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 4

 TERMINÉ 

A comprehensive analysis of microRNA-124 regulated gene networks and its role in epilepsy. (EpiMIRgen)

Date de fin: 1 juil. 2016,

Evidence is emerging that rapid, profound and persisting changes in gene expression regulation and post-transcriptional regulation underlies the epileptogenic process. The current proposal builds on preliminary data which demonstrates that rapid reduction of a microRNA; miR-124, causes increased expression and activity of NRSF, a master-regulator of epileptogenesis. The current proposal will buil ...
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 1

 TERMINÉ 

Predictive Genomic Biomarkers Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer (ANGIOPREDICT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,

In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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 12

 TERMINÉ 

TRANSLATIONAL RESEARCH AND PATIENT SAFETY IN EUROPE (TRANSFoRm)

Date du début: 1 mars 2010, Date de fin: 30 nov. 2015,

TRANSFoRm will develop rigorous, generic methods for the integration of Primary Care clinical and research activities, to support patient safety and clinical research via:1.\tRich capture of clinical data, including symptoms and signs rather than just a single diagnosis. A generic, dynamic interface, integrated with electronic health records (EHR), will facilitate both diagnostic decision support ...
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 25

 TERMINÉ 

Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
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 15

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2014, Date de fin: 30 sept. 2015,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Collagen scaffolds for bone regeneration: applied biomaterials, bioreactor and stem cell technology (COLLREGEN)

Date du début: 1 nov. 2009, Date de fin: 30 sept. 2015,

Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of ...
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 1

 TERMINÉ 

European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interaction ...
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 27

 TERMINÉ 

Live Video-to-Video Supporting Interactive City Infrastructure (LiveCity)

Date du début: 1 avr. 2012, Date de fin: 31 janv. 2015,

The aim of LiveCity is to empower the citizens of a city to interact with each other in a more productive, efficient and socially useful way by using high quality video-to-video (v2v) over the Internet. Video-to-video can be used to save patients' lives, improve city administration, reduce fuel costs, reduce carbon footprint, enhance education and improve city experiences for tourists and cultural ...
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 18

 TERMINÉ 

Apoptosis Modelling for Treatment Decisions in Colorectal Cancer (APO-DECIDE)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2014,

"With the arrival of new colorectal cancer (CRC) therapeutics targeting specific cell signalling pathways, such as anti-EGFR therapy, personalised cancer treatment is at the door step of clinical practise. This progress in drug development contrasts strikingly with current clinical practice, where decision making depends largely on clinical factors such as tumour staging and age of patient, with t ...
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 7

 TERMINÉ 

European Research Ethics Committees’ Network (EURECNET)

Date du début: 1 mars 2011, Date de fin: 31 août 2014,

EURECNET is a network that brings together national REC associations, networks or comparable initiatives but also other bodies relevant in the field of research involving human participants like National Ethics Councils and the European Commission’s ethical review system. Such a network forms the infrastructural basis to promote awareness of specific working practices of RECs across Europe, to enh ...
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 22