7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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20
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TERMINÉ
Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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13
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TERMINÉ
Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strateg (ACTION)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, a ...
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12
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TERMINÉ
IMAging GEnetics for MENtal Disorders (IMAGEMEND)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research literature exists, few neuroimaging applications have reached clinical practice in psychiatry. A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. I ...
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15
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TERMINÉ
Mechanisms and Treatment of Migraine and its Chronification (EUROHEADPAIN)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,
Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailmen ...
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14
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TERMINÉ
Collaborative Oncological Gene-environment Study (COGS)
Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,
The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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16
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TERMINÉ
European Network for Genetic and Genomic Epidemiology (ENGAGE)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,
"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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