3 projets européens trouvés
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TERMINÉ
Model-based preclinical development of anti-tuberculosis drug combinations (PREDICT-TB)
Date du début: 1 mai 2012, Date de fin: 30 oct. 2017,
Drug development in TB requires new integrated methods to transition the novel combination regimens needed to shorten first-line therapy and combat multi-drug resistance. Although new agents are emerging, the path to registration of such regimens remains uncertain while capacity for pivotal trials is limited. Selection and optimization of drug combinations for development depends on preclinical sy ...
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23
Participants partenaires
TERMINÉ
Training Network on Zebrafish Infection Models for Pharmaceutical Screens (FishForPharma)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Infectious diseases caused by pathogenic micro-organisms are major causes of death, disability, and social and economic disruption for millions of people. During evolution these pathogens have developed intricate strategies to manipulate host defence mechanisms and outwit the immune system. To reduce the burden of infectious diseases it is important to increase understanding of these host-pathogen ...
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10
Participants partenaires
TERMINÉ
Developing high-thoughput bioassays for human cancers in zebrafish (ZF-CANCER)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,
"Recently the zebrafish has emerged as a new important system for cancer research because the zebrafish genome contains all orthologs of human oncogenes and forms tumors with similar histopathological and gene profiling features as human tumors. The zebrafish provides an in vivo vertebrate model for identifying novel mechanisms of cancer progression and for development of new anticancer compounds ...
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