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14 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 

Genome Stability Mechanisms in Aging (GENSTAGE)

Date du début: 1 juil. 2011, Date de fin: 28 févr. 2017,

"Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant experimental system to study the role of genome stability in aging. Using the NER system we recently uncovered a novel link ...
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 2

 TERMINÉ 

European Bank for induced pluripotent Stem Cells (EBISC)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 TERMINÉ 

Zebrafish Regulomics for Human Health (ZF-HEALTH)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2015,

In recent years, the zebrafish has emerged as a new vertebrate model organism for biomedical research which offers a unique combination of traits: a short generation time, small size and efficient breeding procedures make it the best choice among vertebrates for forward genetic screening and small-molecule screens, including toxicology, while the transparent embryo and larva offers unique opportun ...
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 20

 TERMINÉ 

Systems Biology of Stem Cells and Reprogramming (SyBoSS)

Date du début: 1 juin 2010, Date de fin: 30 nov. 2015,

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by ...
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 11

 TERMINÉ 

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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 20

 TERMINÉ 

Longevity assurance genes in tumor suppression (SkinCaAge)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

DNA damage has been implicated as a causal factor of cancer development and is thought to contribute to aging. The effect of DNA damage both in cancer and aging becomes particularly apparent in patients that are defective in nucleotide excision repair (NER). NER comprises two distinct branches that differ in the initial damage recognition and lead to distinct clinical outcomes. Global genome (GG) ...
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 1

 TERMINÉ 

Molybdate transport in animals. Role of gephyrin (MoT Gephyrin)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2012,

Molybdenum (Mo) is an essential micronutrient for almost all living beings. Mo participates as cofactor (Moco) in the active site of more than 50 Mo-enzymes that are involved in vital processes such as inorganic nitrogen assimilation, sulphur metabolism, phytohormone biosynthesis, and stress reactions. Mo is acquired by cells in form of the anion molybdate. Molybdate transport process is well know ...
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 1

 TERMINÉ 

Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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 11

 TERMINÉ 

High-Performance OLED-Microdisplays\nfor Mobile Multimedia HMD and Micro-Projection Applications (HYPOLED)

Date du début: 1 janv. 2008, Date de fin: 30 sept. 2010,

Mobile communication has changed the way we live and will continue to do so. In future mobile multimedia will be a key driver for mobile communication. As handsets become more video oriented (TV, DVD, MP4, games etc) the small size of handsets forces a more restrictive limit to the size of display. High definition wearable virtual displays for hands-free viewing and low-cost low-power mobile-inte ...
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 7